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Method for separating and preparing pyrrole butyric acid self-emulsion from radix ranunculi ternati and application of pyrrole butyric acid self-emulsion

A technology of pyrrobutyric acid and self-microemulsion, which is applied in the field of preparation of pyrrolobutyric acid self-microemulsion, can solve the problems of affecting curative effect, difficulty in absorption, poor water solubility and fat solubility, etc., and achieves improved bioavailability and simple preparation , the effect of increasing surface area and solubility

Inactive Publication Date: 2015-06-10
JIANGSU YONGZHANG WEIYE HEALTH TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pyrrobutyric acid has poor water solubility and fat solubility, and it is difficult to absorb in the body, which affects the exertion of curative effect

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] This embodiment is a method for isolating and preparing pyrrolidine self-microemulsion from Cat's Claw. The steps of the method include:

[0031] (1) Raw material processing: use the crushed granules of cat's claw medicinal material or the decoction pieces of cat's claw as raw materials;

[0032] (2) Preparation of the extract: add 6 times the volume of ethanol with a volume percentage concentration of 10%-80% to the raw material, heat and reflux for extraction twice, 1 each time, to obtain the extract;

[0033] (3) Concentrate the extract: filter the extract obtained in the previous step, combine the extract, recover ethanol under reduced pressure, and concentrate the extract to 0.25 g crude drug / ml to obtain a concentrated extract;

[0034] (4) Macroporous resin chromatography: filter or centrifuge the concentrated extract obtained in the previous step and pass it through a chromatographic column filled with a weakly polar macroporous resin. The mass ratio of the extr...

Embodiment 2

[0041] On the basis of Example 1, this example is a method for isolating and preparing pyrrolidine self-microemulsion from Cat's Claw. The steps of the method include:

[0042] (1) Raw material processing: use the crushed granules of cat's claw medicinal material or the decoction pieces of cat's claw as raw materials;

[0043] (2) Preparation of the extract: add 15 times the volume of ethanol with a volume percentage concentration of 10%-80% to the raw material, heat and reflux for extraction 4 times, each time for 3 hours, to obtain the extract;

[0044] (3) Concentrating the extract: filter the extract obtained in the previous step, combine the extract, recover ethanol under reduced pressure, and concentrate the extract to 2.0 g crude drug / ml to obtain a concentrated extract;

[0045] (4) Macroporous resin chromatography: filter or centrifuge the concentrated extract obtained in the previous step and pass it through a chromatographic column filled with a weakly polar macroporo...

Embodiment 3

[0053] On the basis of Example 1, this example is a method for isolating and preparing pyrrolidine self-microemulsion from Cat's Claw. The steps of the method include:

[0054] (1) Raw material processing: use the crushed granules of cat's claw medicinal material or the decoction pieces of cat's claw as raw materials;

[0055] (2) Preparation of the extract: add 9 times the volume of ethanol with a volume percentage concentration of 40% to the raw material, heat and reflux extraction for 3 times, each time for 2 hours, to obtain the extract;

[0056] (3) Concentrating the extract: filter the extract obtained in the previous step, combine the extract, recover ethanol under reduced pressure, and concentrate the extract to 0.9 g crude drug / ml to obtain a concentrated extract;

[0057] (4) Macroporous resin chromatography: filter or centrifuge the concentrated extract obtained in the previous step and pass it through a chromatographic column filled with a weakly polar macroporous ...

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Abstract

The invention discloses a method for separating and preparing pyrrole butyric acid self-emulsion from radix ranunculi ternati and the application of the pyrrole butyric acid self-emulsion. In the method, smashed particles of the radix ranunculi ternati herb or radix ranunculi ternati decoction pieces serve as raw material and are concentrated, extracted and washed to obtain the effective constituent pyrrole butyric acid, and then the pyrrole butyric acid self-emulsion is prepared. According to the method, the effective constituent pyrrole butyric acid can be efficiently extracted, and the radix ranunculi ternati serving as the natural raw material has the advantages of being easy to obtain and low in cost. Serving as a good carrier for drugs which are hard to dissolve and absorb, the pyrrole butyric acid self-emulsion prepared through the method can greatly increase the oral bioavailability of the drugs; a drug delivery system of the pyrrole butyric acid self-emulsion is easy to prepare and stable in nature and is a good carrier for improving the absorbability of the drugs which are hard to dissolve; as is proven in experimental verification, the pyrrole butyric acid self-emulsion prepared through the method has an excellent tubercle bacillus inhibiting effect.

Description

technical field [0001] The present invention relates to a preparation method and application of pyrrobutyric acid self-microemulsion, in particular to a method and application of separating and preparing pyrrolebutyric acid self-microemulsion from cat's claw. Background technique [0002] Cat's claw grass is a newly discovered medicine for treating tuberculosis in Xinyang, Henan Province in the 1950s. It has the functions of clearing heat and detoxifying, dissipating stagnation and eliminating blood stasis, and is mainly used to treat pulmonary tuberculosis, lymphatic tuberculosis, and pharyngitis. Its original plant is Ranunculus ternatus Thunb., a plant of the family Ranunculaceae. Cat's claw grass capsules made from cat's claw water decoction extract are clinically used for the treatment of various tuberculosis with positive curative effect. The study of pharmacological activity shows that the pyrrolidine contained in cat's claw has a strong anti-tuberculosis effect. P...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61K9/107A61P31/06C07D207/333A61K31/40
Inventor 张琳张大伟李卫国李锡敏黄河叶昌荣
Owner JIANGSU YONGZHANG WEIYE HEALTH TECH
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