Administration composition and preparation method and using method thereof

A composition and drug delivery technology, applied in the direction of pharmaceutical formulations, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve low bioavailability, difficult absorption, no safe and effective solutions, etc. question

Active Publication Date: 2011-06-22
SHANGHAI BIOLAXY MEDICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the addition of such high doses of absorption enhancers in oral formulations often leads to toxic reactions and safety concerns
[0007] So far, there is no safe and effective solution for those oral drugs that are poorly absorbed and have low bioavailability

Method used

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  • Administration composition and preparation method and using method thereof
  • Administration composition and preparation method and using method thereof
  • Administration composition and preparation method and using method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0015] A drug composition comprising:

[0016] a) Solid preparations containing effective therapeutic components, absorption enhancers and excipients;

[0017] b) A bioadhesive layer consisting of a bioadhesive polymer.

[0018] The administration composition of the present invention also includes an anti-permeation or semi-permeable coating layer, so that the therapeutic components and absorption promoters in the preparation have unidirectional release capability.

[0019] The release rates of the therapeutic component and the absorption enhancer from the solid dosage form in the present invention are nearly synchronized.

[0020] The administration composition of the present invention also includes an enteric layer.

[0021] In the present invention, the adhesive polymer is selected from one or more of carbomer, polycarbophil, hydroxypropyl methylcellulose, chitosan and their salts or derivatives.

[0022] The impermeable or semipermeable layer in the present invention co...

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PUM

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Abstract

The invention provides an administration composition for transferring medicaments and a preparation method and a using method thereof. The administration composition comprises a solid preparation carrying the effective dose of treatment components, a sorbefacient, a pharmaceutic adjuvant and a biologic adhesion layer containing biologic adhesion polymer, and also comprises a selectable anti-permeable or semipermeable coating layer, so that the treatment components and the sorbefacient in the preparation have unidirectional releasing capacity. The administration composition can promote the absorption of medicaments which are difficult to absorb, improves bioavailability, regulate pharmacokinetic characteristics and improve the absorption efficiency of the medicaments, has low cost and is easy to produce relatively.

Description

technical field [0001] The invention mainly relates to the field of drug delivery, and is especially suitable for pharmaceutical components with poor absorption and low bioavailability in traditional administration, so as to improve the absorption and bioavailability of therapeutic drugs. In particular, the invention relates to drug delivery compositions and methods for their preparation and use. Background technique [0002] Oral administration is the most common and most acceptable way of administration. But for many drugs, the absorption efficiency of oral administration is not good. For example, biologically active macromolecules such as proteins, polypeptides, polysaccharides, and nucleic acids cannot usually be administered orally due to factors such as enzymatic degradation, poor absorption, or instability. Similarly, many small molecule drugs, such as cyclosporine A, fenofibrate, statin lipid-lowering drugs, sartan antihypertensive drugs, antibiotics such as ceftri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K47/32A61K47/36A61K47/38
Inventor 李伟华陆峰尹民邵留英佘昊沈舟
Owner SHANGHAI BIOLAXY MEDICAL SCI & TECH
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