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Medicinal composition for improving psychological sub-health state, preparation method and application thereof

A health state and composition technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of slow evolution process, complex reasons for the development of mental sub-health state, lack of treatment methods, etc.

Active Publication Date: 2018-04-03
SHANXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The reasons for the occurrence and development of mental sub-health are complex, the evolution process is slow, and are closely related to social environment, economic culture, genetics, and physical fitness. Modern medicine still lacks effective treatment methods for it.

Method used

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  • Medicinal composition for improving psychological sub-health state, preparation method and application thereof
  • Medicinal composition for improving psychological sub-health state, preparation method and application thereof
  • Medicinal composition for improving psychological sub-health state, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The preparation of embodiment 1 pharmaceutical composition

[0016] Weigh 5 parts of cinnamon, dry and pulverize, add 10 times the amount of distilled water, microwave (power 800W) to assist extraction, filter, and extract the filtrate 3 times with n-hexane, combine the extracts, concentrate under reduced pressure, and obtain the cinnamon extract; 15 parts of Huang, 20 parts of Lily, mixed, crushed, added 10 times the amount of water microwave-assisted extraction twice, 20 minutes each time, combined the extracts, separated by D101 macroporous adsorption resin column chromatography, and then eluted with water to remove Impurities are then eluted with 50% ethanol, the eluate is collected, concentrated, and vacuum-dried to obtain the Lily Rehmannia extract; the above two extracts are mixed evenly to obtain the product.

Embodiment 2

[0017] The establishment of embodiment 2 psychological sub-healthy rat model

[0018] Modeling with compound factors and non-physical stimuli, namely, empty bottle stimulation, electric shock emotional stimulation, irregular diet stimulation, day and night reversal stimulation, and social failure stimulation, to simulate people's eating disorder and irregular work and rest in a highly competitive social environment , Psychological sub-health state caused by excessive mental stress and social failure.

[0019] I empty bottle stimulation: train all rats to carry out 7d empty bottle drinking training. The rats were only given ten-minute regular drinking water at 9:00-9:10 and 21:00-21:10 every day. And each time before giving water, the rats were given three reminders that the water bottles collided with each other.

[0020] After training, start the experiment. Except for the blank group, the other groups were randomly given an empty bottle stimulation at the time of drinking...

Embodiment 3

[0025] Embodiment 3 pharmacodynamic experiment

[0026] 1 experimental animal

[0027] SD adult male healthy rats (Beijing Weitong Lihua Experimental Animal Technology Co., Ltd., license number: SCXK (Beijing) 2014-0012).

[0028] 2 experimental drugs

[0029] Cinnamon, Rehmannia glutinosa, and Lily decoction pieces were purchased from Shanxi Huayang Pharmaceutical Co., Ltd. (batch numbers 120501384, 120519070, and 120816091, respectively). The preparation method of the pharmaceutical composition is the same as in Example 1, and is divided into a high-dose group (22g crude drug / kg), a medium-dose group (11g crude drug / kg), and a low-dose group (5.5g crude drug / kg). Positive control drug: venlafaxine hydrochloride (Chengdu Kanghong Pharmaceutical Group Co., Ltd., specification: 25 mg / tablet, batch number: 090705). Diazepam (Beijing Yimin Pharmaceutical Factory, specification: 2.5mg / capsule, batch number: 0405281). All other chemical reagents were of analytical grade.

[00...

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Abstract

The invention discloses a pharmaceutical composition for improving psychological sub-health state, its preparation method and application. The medicinal composition is prepared from cinnamon, rehmannia glutinosa and lily in a certain mass ratio through a proper extraction method. The results of pharmacological experiments show that the pharmaceutical composition can significantly increase the sugar water preference rate of rats in the animal model of mental sub-health, the ratio of the number of times to open the arms in the elevated cross arm and the ratio of the time to open the arms, and reduce the number of errors in the dark avoidance test of rats And the time of staying in the dark box shows that it can obviously improve the symptoms of depression, anxiety, insomnia and improve learning and memory.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for improving psychological sub-health state, its preparation method and application. Background technique [0002] Mental sub-health is an intermediate state between mental health and mental illness. People in this state, although there is no clear organic disease in the body, have begun to experience various uncomfortable feelings and symptoms psychologically, mainly manifested as unexplained depression, anxiety, learning and memory decline, sleep disturbance, etc. If it does not attract enough attention, it will easily lead to the occurrence of mental illness. [0003] From mental health to mental illness is a process from quantitative change to qualitative change. The occurrence of neuropsychiatric diseases such as depression, anxiety and schizophrenia is mostly due to the continuous aggravation of mental sub-health. Therefore, early detection an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8967A61P25/00A61P25/24A61P25/22A23L33/00
Inventor 田俊生
Owner SHANXI UNIV
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