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Application of Chinese traditional medicine composition in preparing medicine for preventing and curing liver injury

A liver injury and composition technology is applied in the application field of traditional Chinese medicine compositions in the preparation of medicines for preventing and treating liver injury, can solve problems such as liver injury, aggravation, and elevation, and achieve the effect of significant anti-liver injury and outstanding substantive characteristics.

Inactive Publication Date: 2015-07-08
臧孝国
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

4. Other reasons: primary and secondary liver tumors, liver congestion caused by cardiac insufficiency, certain congenital liver diseases, high-priced intravenous nutrition, etc., can all cause liver damage to varying degrees. The early manifestations of these liver damage are often Elevation of ALT (transaminase) or bilirubin, if the cause is not eliminated, the liver damage will be further aggravated

Method used

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  • Application of Chinese traditional medicine composition in preparing medicine for preventing and curing liver injury
  • Application of Chinese traditional medicine composition in preparing medicine for preventing and curing liver injury
  • Application of Chinese traditional medicine composition in preparing medicine for preventing and curing liver injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: Take 18g of Datouguxiao, 20g of the cotyledon leaves of Manhunt, 15g of Zoumajian, 10g of mountain orange, and 20g of Sanchaku, add water to decoct twice, the amount of water added for the first time is 10 times the weight of the medicinal materials, and decoct For 2 hours, the amount of water added for the second time is 8 times the weight of the medicinal material, decoct for 1 hour, combine the decoction, concentrate, dry, and pulverize to obtain Chinese medicine composition granules. The concentration conditions are: 0.07MPa, 60-70°C under reduced pressure When concentrated to 65°C, the relative density is 1.30. The spray-drying conditions are: the inlet air temperature is 120°C, the outlet air temperature is 80°C, the material temperature is 90°C, the atomization pressure is 0.4 MPa, and the spray speed is 10ml / s.

Embodiment 2

[0015] Embodiment 2: the effect of Chinese medicine composition preventing and treating liver injury

[0016] (1) Protective effect of traditional Chinese medicine composition on D-galactosamine (D-galactosamine, D-GalN)-induced acute liver injury in mice

[0017] 1. Test drug: Prepare the test drug according to the method in Example 1 above.

[0018] 2. Method: The mice were divided into 5 groups. The control group was administered with normal saline (0.3mL·d-1) for 7 consecutive days. The drug (2, 4, 8g crude drug amount·kg-1) in each group was gavaged with normal saline and different concentrations of traditional Chinese medicine composition (0.3mL·d-1) for 7 consecutive days, and D-GalN was injected intraperitoneally on the 7th day ( 800mg·kg-1, 0.15mL·10g-1), blood was collected after 16 hours, and AST and ALT activities were measured.

[0019] Table 1 Protective effect of traditional Chinese medicine composition on acute liver injury induced by D-GalN

[0020]

[0...

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Abstract

The invention relates to the application of a Chinese traditional medicine composition in preparing medicine for preventing and curing liver injury. Pharmacological study is performed on the Chinese traditional medicine composition which is composed of 18 parts of ganltheria forrestii diels, 20 parts of elaeagnus glabra leaves, 15 parts of sambucus chinensis, 10 parts of melodinus suaveolens and 20 parts of evodia lepta to find that the Chinese medicine composition has protective effects on acute liver injury in mice induced by D-galactosamine (D-galactosamine and D-Ga1N) and CC14, and has significant progress.

Description

technical field [0001] The invention relates to the new application of the traditional Chinese medicine composition, in particular to the application of the traditional Chinese medicine composition in the preparation of medicines for preventing and treating liver damage. Background technique [0002] There are multiple reasons for causing liver damage: 1. Viral infection: caused by a variety of hepatitis viruses, with strong infectivity, complex transmission routes, wide epidemic range, and high incidence rate. 2. Drugs or chemical poisons: Many drugs and chemical poisons can cause liver damage, drug-induced hepatitis or toxic hepatitis. 3. Alcoholism: Alcohol damages the liver very seriously. The consequences of the damage include alcoholic hepatitis, alcoholic fatty liver, and alcoholic cirrhosis, mainly due to the toxicity of alcohol (ethanol) and its metabolite acetaldehyde on liver cells. caused by direct damage. 4. Other reasons: primary and secondary liver tumors, l...

Claims

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Application Information

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IPC IPC(8): A61K36/754A61P1/16
Inventor 臧孝国
Owner 臧孝国
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