Applications of miR-455-3p in diagnosis, treatment and prognosis of esophageal squamous cancer

A technology for squamous cell carcinoma of the esophagus, applied in gene therapy, medical preparations containing active ingredients, biochemical equipment and methods, etc., can solve problems such as difficult to kill tumor stem cells
CN104774929AActive Publication Date: 2015-07-15SUN YAT SEN UNIV CANCER CENT
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SUN YAT SEN UNIV CANCER CENT
Publication Date
2015-07-15

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Abstract

The invention discloses applications of miR-455-3p in the diagnosis, treatment, and prognosis of esophageal squamous cancer. The inventor finds that the obviously low survival rate of ESCC patients is related with the high expression of miR-455-3p in ESCC patients. The in-vitro and in-vivo experiment results show that miR-455-3p is capable of promoting the malignant progression of ESCC, by inhibiting the expression of miR-455-3p, the ESCC stem cell characteristics can be inhibited, and the sensitivity of ESCC stem cells to chemotherapy drugs is enhanced; so an expression inhibitor of miR-455-3p can inhibit the tumor stem cells, and is capable of inhibiting the tumor stem cell characteristics and enhancing the sensitivity of the cancer stem cells to chemotherapy drugs. The invention finds the expression of miR-455-3p in cancer patients for the first time, and the expression can be used as auxiliary diagnosis and / or prognosis of ESCC. The invention provides a novel diagnosis method, a novel treatment method, and a pharmaceutical drug screening platform for tumor diseases.
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Description

Technical field

[0001] The invention is a biotechnology field, which involves a new application of Microrna and its Antagomir, which specializes in the application of MIR-455-3P and Antagomir-455-3P. Background technique

[0002] ESOPHAGEAL SQUAMOUS CARCINOMA (ESCC) is one of the most common malignant tumors in the world, with its mortality rate sixth.About 90%of my country's esophageal cancer is squamous cell carcinoma, and it has significant regionality. The incidence of esophageal squamous cell carcinoma in high incidence areas is 500 times that of low incidence areas.Factors such as the history of tobacco and alcohol, the lack of nutrition, the hot food, and the intake of carcinogen are all related to esophageal squamous cell carcinoma.Surgery and chemotherapy are important treatment methods for esophageal squamous cell carcinoma, but their 5 -year survival rate is only about 10%.Drug resistance is difficult to overcome the treatment of esophageal squamous cell carcinoma.Trad...

Claims

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