Application of dezocine to prepare medicament for alleviating hyperpathia related to opioids after operation
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A technology of opioids and hyperalgesia, which is applied in the application of drugs, in the field of dezocine, can solve problems such as poor therapeutic effect, achieve the effect of reducing the range of hyperalgesia, high satisfaction, and satisfactory pain control effect
Inactive Publication Date: 2015-07-22
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[0007] The object of the present invention is to provide the application of dezocine in the preparation of drugs for alleviating opioid-related hyperalgesia after surgery, and the application of dezocine in the preparation of drugs for alleviating opioid-related hyperalgesia after surgery should solve the following problems: Technical Problems of the Prior Art's Ineffective Therapeutic Effects on Postoperative Opioid-Associated Hyperalgesia
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[0018] 1. Research objects and methods
[0019] 1. Research object
[0020] Patient inclusion criteria:
[0021] Patients who underwent elective open gastrectomy in our hospital from August 2012 to February 2014 were selected;
[0022] Aged 18-64 years old;
[0023] ASA I or II;
[0024] Patients with non-end-stage tumors were assessed preoperatively.
[0025] Preoperative exclusion criteria:
[0026] Chronic or analgesic drugs used within 24 hours before surgery;
[0027] History of diabetes or high blood pressure;
[0028] neurological or psychiatric disease;
[0029] Laboratory tests: blood routine, liver and kidney function, electrolyte or coagulation abnormalities;
[0030] Positive findings on imaging or ECG;
[0031] Rapid extubation was not planned after surgery;
[0032] The patient fails to understand or refuses to cooperate;
[0033] History of alcohol consumption or coffee consumption >2 cups / day;
[0034] BMI index >30 or <17.
[0035] Intraoper...
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Abstract
The invention discloses an application of dezocine to prepare medicament for alleviating hyperpathia related to opioids after operation, which belongs to the field of pharmaceutical chemistry. According to the invention, it is proved by clinical tests that the morbidity of hyperpathia related to opioids after operation of patients suffering morbidity can reach as high as 88%, and hyperpathia of the whole body of a patient after operation can be alleviated by intravenous injection of dezocine. The range of hyperpathia around an operative incision is decreased; the use amount of PCIA after operation is reduced; the satisfaction degree of pain control for the patients is high; and no server side effect due to single-dose intravenous injection of dezocine is found.
Description
Technical field: [0001] The invention belongs to the field of medicinal chemistry, and in particular relates to the application of dezocine, in particular to the application of dezocine in the preparation of medicament for alleviating opioid-related hyperalgesia after operation. Background technique: [0002] Dezocine, chemical name: (-)-[5R-(5α,11α,13S*)]-13-amino-5,6,7,8,9,10,11,12-octahydro-5- Methyl-5,11-methylenebenzocyclodecen-3-ol, the structural formula is: [0003] [0004] Molecular formula: C 16 h 23 NO, molecular weight: 245.36, is a powerful opioid analgesic. Dezocine can relieve postoperative pain, and its analgesic intensity, onset time and duration of action are comparable to morphine. [0005] Clinically, postoperative patients often develop hyperalgesia, manifested as increased sensitivity to painful stimuli, in other words, they feel general painful stimuli before surgery, and after hyperalgesia occurs, the same stimuli will lead to enlarged pain se...
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