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Novel application of acanthopanax polysaccharide

A technology of Acanthopanax senticosus polysaccharides and new uses, applied in the field of Acanthopanax senticosus polysaccharides, can solve problems such as liver cell damage

Inactive Publication Date: 2015-08-05
刘树民
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Common drugs for the treatment of immune liver damage, such as bifendate dripping pills, etc., long-term use can cause liver cell damage, leading to acute liver failure, acute hepatitis, cholestatic hepatitis, fatty liver, vascular damage and other side effects

Method used

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  • Novel application of acanthopanax polysaccharide
  • Novel application of acanthopanax polysaccharide
  • Novel application of acanthopanax polysaccharide

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0021] Specific Embodiment 1: The new use of Acanthopanax polysaccharides in this embodiment refers to the use of Acanthopanax polysaccharides in the preparation of drugs for treating immune liver damage.

[0022] Acanthopanax Senticosus Polysaccharides (ASPS) is a plant polysaccharide extracted from the roots and rhizomes of Acanthopanax Senticosus, a plant of the genus Araliaceae. It is a kind of macromolecular substance with natural properties, a kind of natural high molecular polymer formed by connecting aldose or ketose through glycosidic bonds in different forms, and it is one of the main active ingredients of Acanthopanax.

[0023] In the application of Acanthopanax polysaccharide of the present invention in the treatment of immune liver injury, it is found that Acanthopanax polysaccharide ASPS has a certain preventive and protective effect on immune liver injury, and the protective effect of polysaccharide on liver injury is not only directly reflected in liver protecti...

specific Embodiment approach 2

[0024] Embodiment 2: This embodiment differs from Embodiment 1 in that the dosage of the drug is 15.93 mg / kg / d. Others are the same as in the first embodiment.

specific Embodiment approach 3

[0025] Embodiment 3: The difference between this embodiment and Embodiment 1 or 2 is that the drug is administered orally. Others are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses novel application of an acanthopanax polysaccharide. The acanthopanax polysaccharide is applied to preparation of a drug for treating immunological liver injury. The acanthopanax polysaccharide ASPA has certain effects on preventing and protecting immunological liver injury, the protecting effect of the polysaccharide is directly embodied on the aspects of protecting the liver and lowering transaminase, in addition, the activities of SOD and GSH-Px can also be improved through inhibiting MDA, so that the oxidative damage resistance of hepatic cells can be improved. The acanthopanax polysaccharide is applied to the field of pharmaceuticals.

Description

technical field [0001] The invention relates to a new application of Acanthopanax senticosus polysaccharide. Background technique [0002] Immunological Liver Injury (Immunological Liver Injury, ILI) refers to the release of various free radicals, cytokines and inflammatory mediators caused by the immune response, resulting in inflammatory cell infiltration in liver tissue, inflammatory granuloma formation, liver cell Inflammatory immune response characterized by destruction of cable structure, eventually resulting in liver cell necrosis and apoptosis of liver cell damage. The immune mechanism plays a key role in the process of liver injury, and is one of the important pathogenesis of viral hepatitis, liver cirrhosis, and eventually hepatocellular carcinoma, and determines the outcome or development of the disease. The main prevention and treatment methods of immune liver injury are reflected in three aspects: (1) the application of antiviral drugs, such as interferon, nucl...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P1/16
Inventor 刘树民张娜陈平平
Owner 刘树民
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