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A compound traditional Chinese medicine composition with the effect of treating heart failure, its preparation method and application

A heart failure and anti-inflammatory technology, which is applied in drug combinations, medical preparations containing active ingredients, and pharmaceutical formulas, can solve the problems of activating neuroendocrine, unknown long-term efficacy, and few studies, so as to improve clinical symptoms and drug safety. Reliable, Medication-Strict Effects

Active Publication Date: 2018-08-28
JIANGSU PROVINCIAL HOSPITAL OF TCM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, based on many years of clinical experience, combined with modern medicine, Professor Li Qiyi believes that the current understanding of pathological factors in traditional Chinese medicine does not pay attention to "phlegm", the understanding of etiology and pathogenesis does not pay attention to "yin deficiency", and the treatment method pays too much attention to yang deficiency water Although the product of warming the yang and diuresis is used in a short-term manner, it is suspected of activating neuroendocrine, and the long-term efficacy is unknown. From the perspective of evidence-based medicine and large-scale foreign clinical trials, the focus of evaluation of the efficacy of chronic heart failure should be in the long-term. Evaluation, that is, the evaluation of the incidence of mortality and cardiovascular events, but there are few domestic studies on this, and there is still a gap in traditional Chinese medicine

Method used

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  • A compound traditional Chinese medicine composition with the effect of treating heart failure, its preparation method and application
  • A compound traditional Chinese medicine composition with the effect of treating heart failure, its preparation method and application
  • A compound traditional Chinese medicine composition with the effect of treating heart failure, its preparation method and application

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Effect test

Embodiment 1

[0033] 1. A compound Chinese medicine composition with the effect of treating heart failure, which is made of the following raw materials in parts by weight: Radix Astragali Radix Sunburne 30g, Radix Astragali Radix Raw 30g, Cornus officinalis 12g, Ophiopogon japonicus 15g, seaweed 15g, cassia twig 9g, raw Puhuang 10g, Passepartout 30g.

[0034] 2. A preparation method of a medicament for treating heart failure, comprising the following steps:

[0035] (1) Take Radix Astragali Radix Sunburne 30g, Raw Astragalus Radix 30g, Ophiopogon japonicus 15g, and Seaweed 15g in parts by weight, add 10 times the volume of the medicinal materials to decoct and extract 3 times, each time for 2 hours, to obtain a water extract, concentrate, and obtain extract;

[0036] (2) Take 12g of Cornus officinalis and 9g of cassia twig in parts by weight, add 8 times the volume of the medicinal material to decoct and extract twice, each time for 3 hours, add ethanol, make the volume concentration of et...

Embodiment 2

[0040] 1. A traditional Chinese medicine compound composition with the effect of treating heart failure, which is made of the following raw materials in parts by weight: Radix Astragali 60g, Raw Astragalus 60g, Cornus officinalis 24g, Ophiopogon japonicus 30g, Seaweed 30g, Guizhi 18g, Raw Puhuang 20g, Passepartout 60g.

[0041] 2. A preparation method of a medicament for treating heart failure, comprising the following steps:

[0042](1) Take Radix Astragali 60g, Raw Radix Astragali 60g, Ophiopogon japonicus 30g, and Seaweed 30g in parts by weight, add 12 times the volume of medicinal materials to decoct and extract twice, each time for 3 hours, to obtain a water extract, concentrate, and obtain extract;

[0043] (2) Take 24g of Cornus officinalis and 18g of cassia twig in parts by weight, add 10 times the volume of the medicinal material to decoct and extract 3 times, each time for 2 hours, add ethanol, make the volume concentration of ethanol be 85% and carry out alcohol pr...

Embodiment 3

[0047] 1. A traditional Chinese medicine compound composition with the effect of treating heart failure, which is made of the following raw materials in parts by weight: Radix Astragali Radix Sunburn 90g, Radix Astragali Radix Raw 90g, Cornus officinalis 36g, Radix Radix Radix 45g, seaweed 45g, cassia twig 27g, raw Puhuang 30g, Passepartout 90g.

[0048] 2. A preparation method of a medicament for treating heart failure, comprising the following steps:

[0049] (1) Take 90g Sun-paste Astragalus, 90g Raw Astragalus, 45g Ophiopogon japonicus, and 45g seaweed in parts by weight, add 10 times the volume of medicinal materials to decoct and extract twice, each time for 2 hours, to obtain a water extract, concentrate, and obtain extract;

[0050] (2) Take 36g of Cornus officinalis and 27g of cassia twig in parts by weight, add 8 times the volume of the medicinal material to decoct and extract twice, each time for 2 hours, add ethanol, make the volume concentration of ethanol be 75%...

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Abstract

The invention discloses a traditional Chinese medicine compound composition with the effect of treating heart failure and its preparation method and application. 15-45 parts of seaweed, 9-27 parts of cassia twig, 10-30 parts of raw cattail, and 30-90 parts of Passepartout. According to the traditional Chinese medicine theory of syndrome differentiation and treatment, the present invention screens traditional Chinese medicine prescriptions according to the pathogenesis of heart failure. The clinical symptoms, quality of life, heart function, brain natriuretic peptide and other indicators of heart failure patients have obvious effects on the prevention and treatment of heart failure. Moreover, the traditional Chinese medicine compound composition provided by the invention has little toxic and side effects in long-term use, and is safe and reliable for use.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine, in particular to a compound traditional Chinese medicine composition capable of treating heart failure, a preparation method and application thereof. Background technique [0002] Chronic congestive heart failure (CHF) is a complex and severe clinical syndrome in which ventricular filling or blood ejection is reduced due to structural or functional abnormalities of the heart. It is the inevitable outcome of most organic heart diseases. The prevalence and incidence are still increasing, and the 5-year survival rate is similar to that of malignant tumors, making it the most important cardiovascular disease in the 21st century. How to effectively treat heart failure has become an important topic in the world today. In recent years, due to the development of molecular biology, the understanding of its occurrence and development mechanism is gradually deepening. At present, it is believed th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8968A61P9/04
Inventor 李七一严士海赵惠
Owner JIANGSU PROVINCIAL HOSPITAL OF TCM
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