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Medicine for hyperlipemia and atherosclerosis treating and preparation method and application

A technology for atherosclerosis and hyperlipidemia, applied in the field of medicine, can solve problems such as adverse reactions, achieve significant curative effect, broad medicinal value, and good application prospects

Inactive Publication Date: 2015-09-30
GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although a variety of western medicines have lipid-lowering effects, long-term use often has adverse reactions
Polygonum multiflora (Fallopia multiflora Harald), as a traditional Chinese herbal medicine with a long history, has obvious pharmacological effects in anti-aging, antibacterial, enhancing the immune function of the body, and promoting the regeneration and development of blood cells. There are few reports and studies on sclerosis

Method used

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  • Medicine for hyperlipemia and atherosclerosis treating and preparation method and application
  • Medicine for hyperlipemia and atherosclerosis treating and preparation method and application
  • Medicine for hyperlipemia and atherosclerosis treating and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0184] Example 1. Formula: emodin 80g, aloe-emodin 4g.

[0185] Preparation method: 1) Polygonum multiflorum processing: Take appropriate amount of raw Polygonum multiflorum decoction slices, put it in a non-iron container, add appropriate amount of black bean juice according to the weight ratio of 16:1 and mix well (10g of black beans for every 160g of Polygonum multiflorum), stew for 8 hours, then Put it in a non-iron steamer and steam it with water for 48 hours, mix it back to the steamed liquid, take it out and place it in the sun at 60°C to obtain Shouwu, and store it for later use.

[0186] 2) Extraction of free anthraquinone: Shouwu was crushed into coarse powder, refluxed with ethanol for extraction three times, each time for 1 hour, ethanol was recovered under reduced pressure, the concentrated solution was dispersed by adding 1:1 dilute hydrochloric acid solution, extracted with chloroform until colorless, reduced The chloroform was recovered under pressure, and dri...

Embodiment 2

[0190] Example 2. Formula: emodin 100g, aloe-emodin 6g.

[0191] Preparation method: 1) Polygonum multiflorum processing: Take appropriate amount of raw Polygonum multiflorum decoction slices, put it in a non-iron container, add appropriate amount of black bean juice according to the weight ratio of 16:1 and mix well (10g of black beans for every 160g of Polygonum multiflorum), stew for 8 hours, then Put it in a non-iron steamer and steam it in water for 48 hours, mix it back to the steamed liquid, take it out and place it in the sun at 60°C intermittently to obtain Radix Polygoni Multiflori, and store it for later use;

[0192] 2) Extraction of free anthraquinone: Shouwu was crushed into coarse powder, refluxed with ethanol for extraction three times, each time for 1 hour, ethanol was recovered under reduced pressure, the concentrated solution was dispersed by adding 1:1 dilute hydrochloric acid solution, extracted with chloroform until colorless, reduced Recover chloroform ...

Embodiment 3

[0196] Example 3. Formula: emodin 70g, aloe-emodin 3g.

[0197] Preparation method: 1) Polygonum multiflorum processing: Take appropriate amount of raw Polygonum multiflorum decoction slices, put it in a non-iron container, add appropriate amount of black bean juice according to the weight ratio of 16:1 and mix well (10g of black beans for every 160g of Polygonum multiflorum), stew for 8 hours, then Put it in a non-iron steamer and steam it in water for 48 hours, mix it back to the steamed liquid, take it out and place it in the sun at 60°C intermittently to obtain Radix Polygoni Multiflori, and store it for later use;

[0198] 2) Extraction of free anthraquinone: Shouwu was crushed into coarse powder, refluxed with ethanol for extraction three times, each time for 1 hour, ethanol was recovered under reduced pressure, the concentrated solution was dispersed by adding 1:1 dilute hydrochloric acid solution, extracted with chloroform until colorless, reduced Recover chloroform u...

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Abstract

The invention discloses medicine for hyperlipemia and atherosclerosis treating and a preparation method and an application. The medicine is prepared by raw materials, by weight, 80-100 parts of rheum emodin and 4-6 parts of aloe emodin which are active ingredients in a polygonum multiflorum free anthraquinone derivant. The invention discloses the novel application for the polygonum multiflorum free anthraquinone derivant, a wide application prospect and a medicinal value are provided for the research for polygonum multiflorum which serves as traditional old medicine and active ingredients of the polygonum multiflorum. The active ingredients such as the rheum emodin and the aloe emodin which are screened in the polygonum multiflorum free anthraquinone derivant serve as the raw materials, the prepared medicine has an obvious effect on aspects such as the hyperlipemia treating and AS treating, and the good application prospect is obtained.

Description

technical field [0001] The invention relates to a medicine for treating hyperlipidemia and atherosclerosis and a preparation method thereof, and the application of Polygonum multiflorum free anthraquinone derivatives in preparing medicines for treating hyperlipidemia and atherosclerosis, belonging to the technical field of medicine . Background technique [0002] Hyperlipidemia (Hyperlipidemia) is closely related to atherosclerosis (AS), and is one of the important causes of cardiovascular and cerebrovascular diseases. With the continuous improvement of people's living standards and changes in diet structure, the incidence of hyperlipidemia in my country is on the rise year by year. Therefore, the prevention and treatment of hyperlipidemia has always been one of the important topics in the medical field. Lipid-lowering therapy can reduce or avoid the occurrence of AS, thereby reducing the incidence of coronary heart disease and stroke. Although a variety of western medicin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P3/06A61P9/10
Inventor 杨长福王和生林昶陈云志柴艺汇王世姣
Owner GUIYANG COLLEGE OF TRADITIONAL CHINESE MEDICINE
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