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Application of candesartan in preparing methamphetamine addiction drugs

A technology of methamphetamine and candesartan, which is applied in the field of biomedicine and can solve the problems of TR1 antagonist candesartan, which has not been reported.

Inactive Publication Date: 2015-09-30
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because of the connection between central AngII and the dopamine system, central AngII has gradually entered the field of vision of drug addiction researchers, but there are no relevant reports about the TR1 antagonist candesartan as a detoxification drug for methamphetamine addiction

Method used

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  • Application of candesartan in preparing methamphetamine addiction drugs
  • Application of candesartan in preparing methamphetamine addiction drugs
  • Application of candesartan in preparing methamphetamine addiction drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] Example 1 The administration of candesartan has an inhibitory effect on the spontaneous activity behavior of rats induced by methamphetamine

[0051] The locomotor activity test is a common method for central nervous system safety pharmacology evaluation and neuroscience research, and it is an important method that can provide parameters for various pharmacological research purposes, including central nervous system safety pharmacology research.

[0052] Methods: The rats were injected with methamphetamine intraperitoneally for 14 consecutive days, and then they were allowed to perform spontaneous activities in the spontaneous activity box every day, and the behavior of the rats was observed. On the 15th day, all rats were divided into 4 groups, 8 in each group, respectively normal saline group, low dose candesartan group, high dose candesartan group and vehicle group:

[0053] ①Normal saline group: 0.37ml of normal saline was given to the abdominal cavity before the te...

Embodiment 2

[0057] Example 2 Candesartan has a regulating effect on the temperature of rats after inhaling methamphetamine

[0058] Method: After the rats were sucked methamphetamine for 14 days, they were divided into four groups as in Example 1, and the body temperature of the rats was measured. The results are as follows:

[0059] from image 3 It was observed that the average body temperature of the Saline group was 35.2°C, the average body temperature of the DMSO group was 35.0°C, the average body temperature of the METH+10Candesartan group was 35.4°C, the average body temperature of the METH+10Candesartan group was 35.3°C, and the average body temperature of the METH+DMSO group was 36.6°C. Compared with the METH group, Both the high-dose group and the low-dose group significantly lowered the temperature (compared with the METH group, p value 0.05), it also shows that candesartan can alleviate the fever caused by the abnormality of the thermoregulatory center caused by the central ne...

Embodiment 3

[0060] Example 3 The Effect of Candesartan on the Learning and Memory of Rats After Inhaling Methamphetamine

[0061](1) Place navigation test, used to measure the learning and memory acquisition ability of mice in the water maze. The experiment lasted for 4 days, with one session in the morning and one session in the afternoon, for a total of 8 sessions. Experimentally observe and record the route map and the time required for the mice to find and climb up the platform, that is, record their latency and swimming speed.

[0062] from Figure 4 Observation: Compared with METH group, the latent period of high-dose group is significantly reduced (compared with METH group, p value0.05, high-dose group is more Close to normal saline group, p value > 0.05, no statistical significance. It shows that the administration of high dose group has obvious promoting effect on rat water maze, and candesartan can improve the learning and memory ability of rats after inhaling methamphetamine...

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Abstract

The invention relates to the application of candesartan in preparing methamphetamine addiction drugs, wherein the role of candesartan in treating the rewarding effect of amphetamines addiction behavior incentives is studied. The result of the study shows that, candesartan facilitates the fading of the rewarding effect of the addiction behaviors of mice addicted to amphetamines, and also greatly improves the learning and remembering ability of mice addicted to amphetamines during the water maze training process. Meanwhile, candesartan is capable of obviously regulating the temperatures of mice after taking amphetamines, and inhibiting the methamphetamine rewarding incentives of mice. Moreover, candesartan obviously inhibits the methamphetamine-induced spontaneous activity behaviors of mice. That means, candesartan can be used for the withdrawal of methamphetamine addiction behaviors and the development of novel anti-toxicant drugs.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to a new application of candesartan, in particular to an application of candesartan in the preparation of methamphetamine addictive drugs. Background technique [0002] Methamphetamine (METH) belongs to the amphetamine-type central stimulant, which has various pharmacological and toxicological effects such as central excitatory and appetite suppression, and is a psychoactive drug controlled by the United Nations. Since the 21st century, the world's drug production and consumption patterns have undergone significant changes, and the abuse of new drugs is becoming a rapidly growing and increasingly serious social problem. In particular, amphetamine-type stimulants represented by methamphetamine (METH) are spreading rapidly in the world. Long-term abuse can lead to violence and bring serious adverse consequences to social security. The basic and clinical research on methamphetamine in my count...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4184A61P25/30
Inventor 刘昱黎兴兴郑文慧潘俭
Owner NINGBO UNIV
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