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A kind of traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof

A composition and arthritic technology are applied in the field of traditional Chinese medicine Qianghuo-weiling fairy medicine pair, traditional Chinese medicine composition for the treatment of rheumatoid arthritis and its preparation field, so as to improve the pathological changes of joint tissue, inhibit the swelling of the soles of the feet, significantly resist the Effects of Rheumatoid Arthritis Action

Active Publication Date: 2019-03-22
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there are no literature reports on the biological activity and clinical research of the notopterygium-clematis pair in the treatment of rheumatoid arthritis

Method used

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  • A kind of traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof
  • A kind of traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof
  • A kind of traditional Chinese medicine composition for treating rheumatoid arthritis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0086] Take 10kg of cleaned clematis, mix well with 1.5kg of rice wine, moisten thoroughly, put it in a pot, fry it with a slow fire, take it out, and let it cool; take 2.5kg of notopterygium, mix it with the above wine-roasted clematis, and mix them with 10 times Extracted three times with 75% ethanol by volume, combined the extracts, filtered, concentrated, evaporated to dryness under reduced pressure, pulverized and sieved to obtain dry paste powder, which was packed into capsules to obtain capsules.

Embodiment 2

[0088] Take 10kg of cleaned clematis, mix well with 1.5kg of rice wine, moisten thoroughly, put it in a pot, fry it with a slow fire, take it out, and let it cool; take 2.5kg of notopterygium, mix it with the above wine-roasted clematis, and mix them with 10 times Extracted 3 times with 75% ethanol by volume, combined the extracts, filtered, concentrated, evaporated to dryness under reduced pressure, crushed and sieved to obtain dry cream powder. Take an appropriate amount of the above-mentioned dry cream powder, mix it with the same amount of starch and dextrin, use ethanol at an appropriate concentration as a wetting agent, granulate it by a conventional method, add an appropriate amount of magnesium stearate, and mix it to form a tablet.

Embodiment 3

[0090] Take 10kg of clean clematis, mix well with 1.5kg of rice wine, moisten thoroughly, put it in a pot, fry it with a slow fire, take it out, and let it cool; take 2kg of notopterygium, mix it with the above wine-roasted clematis, and mix them with 10 times the volume Extract 3 times with 85% ethanol, combine the extracts, filter, concentrate, evaporate to dryness under reduced pressure, crush and sieve to obtain dry cream powder. Take an appropriate amount of the above-mentioned dry cream powder, mix it with the same amount of starch and dextrin, use ethanol at an appropriate concentration as a wetting agent, granulate it by a conventional method, add an appropriate amount of magnesium stearate, and mix it to form a tablet.

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Abstract

The invention relates to the field of traditional Chinese medicine, and discloses a traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method thereof. The traditional Chinese medicine composition is a medicine pair of rhizoma et radix notopterygii and radix clematidis. The preparation method of the traditional Chinese medicine composition comprises the steps that 1, clean sections of radix clematidis are taken and evenly mixed through yellow wine to make the radix clematidis sections soaked, the radix clematidis sections are put into a pot to be slightly fried through soft fire, and then the slightly fried radix clematidis sections are taken out and cooled; radix clematidis processed through the method in the first step is mixed with rhizoma et radix notopterygii, wherein the weight proportion of the rhizoma et radix notopterygii to the radix clematidis is 1-5 to 1-5, the mixture is extracted through a 40%-95% ethanol solution, concentration of the extracting solution is conducted, and the traditional Chinese medicine composition for treating the rheumatoid arthritis is obtained after evaporation to dryness is conducted through depression. Pharmacodynamic research results show that the medicine pair of the rhizoma et radix notopterygii and the radix clematidis has the significant effect of being resistant to the rheumatoid arthritis and has good application prospect in preparing drugs for treating the rheumatoid arthritis.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a traditional Chinese medicine composition for treating rheumatoid arthritis and a preparation method thereof. The application effect is remarkable. technical background: [0002] Rheumatoid arthritis (Rheumatoid arthritis, RA) is a chronic, symmetrical, progressive and aggressive polyarthritis as the main manifestation, with joint synovitis and pannus formation as the main pathological features, the etiology is unknown, Systemic autoimmune disease. The incidence rate of RA in Europe and America is 0.5-1.0%, and the prevalence rate in my country is 0.32%-0.36%. The prevalence rate of women is three times that of men. RA is one of the main diseases that cause people to lose their labor force. It has a high disability rate and seriously endangers people's health and quality of life. At present, the drugs for the clinical treatment of RA are mainly divided...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/716A61P37/02A61P29/00A61P19/02
Inventor 李飞李萍
Owner CHINA PHARM UNIV