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Pharmaceutical composition for treating arthritis

A composition and arthritic technology, applied in the field of medicine, to achieve the effects of reducing dosage, increasing safety, and reducing toxic and side effects

Active Publication Date: 2014-07-16
NANTONG FINC PHARMA CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, in the treatment of arthritis, there is no therapeutic drug that uses tetrahydropalmatine or tetrahydropalmatine in combination with acetaminophen as the main active ingredient.

Method used

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  • Pharmaceutical composition for treating arthritis
  • Pharmaceutical composition for treating arthritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Rat Adjuvant Arthritis Model Experiment

[0021] 40 SD rats, weighing 180-220 g, were routinely fed for one week, and injected 0.1 mL of complete Freund's adjuvant into the plantar part of the right hind limb of the rats to establish a pathological model of adjuvant arthritis. The successfully modeled adjuvant arthritis rats were randomly divided into four groups according to body weight, namely, model control group, L-tetrahydropalmatine group (20mg / kg / d), acetaminophen group (30mg / kg), combination Animal group (L-tetrahydropalmatine 20mg / kg / d + acetaminophen 30mg / kg / d) a total of 4 groups, 10 rats in each group. On the 4th day after modeling, the rats in the L-tetrahydropalmatine group, the acetaminophen group, and the composition group were intragastrically administered with the corresponding doses of drugs, and the model control group was intragastrically administered with the same volume of purified water. 1 time, a total of three weeks of administration...

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Abstract

The invention discloses a pharmaceutical composition for treating arthritis, belonging to the technical field of medicines. The pharmaceutical composition contains tetrahydropalmatine and acetaminophen, wherein the weight ratio of the tetrahydropalmatine to the acetaminophen is 1:(0.5-4). The most important advantage of the pharmaceutical composition is synergetic anti-inflammation, and simultaneously the dosage of the tetrahydropalmatine and the acetaminophen in independent use is reduced, so that the cost of medication for a patient is lowered, toxic and side effects of the acetaminophen are alleviated as well, and the safety of medication and the compliance of the patient are improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for treating arthritis. Background technique [0002] Arthritis refers to arthritic lesions caused by inflammation, infection, trauma or other factors. It will cause joint dysfunction to varying degrees, and the course of the disease is long, lingering and difficult to heal, and the common feature is a chronic inflammatory process of progressive development. The main clinical manifestations are joint pain, joint swelling, joint dysfunction and other symptoms, and it is one of the important causes of disability. According to statistics, there are as many as 355 million arthritis patients in the world, and more than 100 million arthritis patients in my country, and the number is still increasing. Arthritis has seriously affected the life, work and study of patients, so the development of therapeutic drugs for arthritis with good effects i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P19/02A61P29/00A61K31/167
Inventor 武素艳
Owner NANTONG FINC PHARMA CHEM
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