A method for improving the metering accuracy of powder mist drug delivery device

Abstract

The invention discloses a method for improving the dosage measurement accuracy of a powder inhalation administration device and belongs to the field of inhalation type administration instruments. A lower flow channel component is subjected to overall knock type vibration through a rotary table by using a vibration gear; meanwhile, a second vibration part namely an inner drug cylinder capable of being synchronously and freely vibrated is also arranged in a drug powder storage container, drug powder in the drug powder storage container is compositely vibrated, and a dual vibration effect is generated by using the structures of master and slave vibration parts, so that the drug powder in the drug powder storage container can more uniformly flow into a quantitative drug tank, the dosage measurement accuracy of a single dosage of drug powder provided by the drug powder storage container of the powder inhalation administration device in each administration process can be better ensured, and the good adaptability of the powder inhalation administration device to the types of drug powder in a larger range is improved. The method for improving the dosage measurement accuracy of the powder inhalation administration device can be widely applied to the fields of designing and manufacturing of the powder inhalation administration devices of various specifications.

Description

technical field [0001] The invention belongs to the field of devices for injecting media into the human body, and in particular relates to an inhalation drug delivery device for sending specified doses of powder aerosol into the patient's lungs through the oral cavity along with the breathing air. Background technique [0002] In modern medical technology, oral or nasal inhalation can make the drug directly enter the lungs and absorb into the blood, avoiding the "first pass" effect of the liver. [0003] Clinically, pulmonary drug delivery is mainly used to treat pulmonary diseases such as asthma, chronic obstructive pneumonia, and cystic fibrosis. Due to the thin wall of alveolar epithelial cells, large surface area, and low enzyme metabolic activity, in recent years, pulmonary drug delivery has gradually become a new way for non-invasive delivery of more drugs (such as peptides and protein drugs, etc.). [0004] In the way of pulmonary drug delivery, powder aerosol has ma...

AI Technical Summary

Problems solved by technology

[0011] In the inverted cone-shaped drug powder storage container in the above technical solution, once its design parameters (inverted cone angle) are determined, it can only adapt to the drug powder in a certain fluidity range. For drug powders with worse fluidity index parameters, it cannot well adapted

When the physical performance index of the filled drug powder (usually refers to the fluidity index of the drug powder) changes, only by redesigning the mechanical design parameters of the inverted cone-shaped drug powder storage container and the vibrating drug delivery unit can the drug delivery rate of each drug delivery be ensured. The metering accuracy of the powder dose supplied in the process (commonly known as the dosage of a single dose), so the powder mist drug delivery device designed and produced can only be aimed at a specific drug powder, and does not have a good type of drug. Adaptability and convenience of mechanical structure parameter design adjustment

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