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Extraction method and application of herbal composition containing herba andrographitis

An extraction method and composition technology, applied in the field of extraction of plant compositions containing Andrographis paniculata, can solve the problems of large dosage for patients, rough and backward technology, and achieve the effect of reducing dosage

Inactive Publication Date: 2015-11-18
NANJING ZHENGLIANG MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of plant compositions containing Andrographis paniculata. However, the method of decocting in water is rough, backward, and has many impurities, which leads to excessive dosage for patients, which is inconvenient to take, and seriously Affected the clinical application of this product

Method used

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  • Extraction method and application of herbal composition containing herba andrographitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Take 100g of Andrographis paniculata, 90g of Cymbidium japonica, 80g of Maihe grass two leaves, 150g of three-point golden grass, grind them, add 2L of 70% ethanol, put them into a microwave extraction device for microwave extraction, the extraction power is 400-600W, extract 2 times, each For 4-8 minutes, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extraction Add conventional excipients and prepare into tablets, 0.4g per tablet.

Embodiment 2

[0016] Take 100g of Andrographis paniculata, 90g of Cymbidium japonica, 80g of Maihe grass two leaves, 150g of three-point golden grass, grind them, add 2L of 70% ethanol, put them into a microwave extraction device for microwave extraction, the extraction power is 400-600W, extract 2 times, each For 4-8 minutes, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extraction and add conventional excipients to prepare capsules.

Embodiment 3

[0018] Take 100g of Andrographis paniculata, 90g of Cymbidium japonica, 80g of Maihe grass two leaves, 150g of three-point golden grass, grind them, add 2L of 70% ethanol, put them into a microwave extraction device for microwave extraction, the extraction power is 400-600W, extract 2 times, each For 4-8 minutes, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute with 50% ethanol, collect 5 times the column volume eluate, recover ethanol under reduced pressure, concentrate and dry to obtain microwave extraction The product is prepared into granules by adding conventional excipients.

[0019] Sanxiang is a plant of the genus Hyptissuaveolens (L.) Poir. in the family Lamiaceae, and is used as medicine with the whole herb. Harvested in summer and autumn, dried in the shade or used fresh. Dispelling wind and promoting dampness, promoting qi circulation and dispelling blood stasis. Used for colds and headaches, gastroenteritis, dysentery, ab...

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Abstract

The invention provides an extraction method of a herbal composition containing herba andrographitis. The herbal composition is prepared from the following medicinal raw materials: 100g of herba andrographitis, 90g of hyptis suaveolens, 80g of maianthemum bifolium and 150g of desmodium triflorum by adopting a microwave extraction method, so that the content is greatly improved, and the usage is reduced. The invention further provides an application of the herbal composition containing herba andrographitis in preparation of medicines for inhibiting cell proliferation of ehrlich ascites cancer ECA of mice.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to an extraction method and application of a plant composition containing Andrographis paniculata. Background technique [0002] The botanical composition containing Andrographis paniculata is made from 100g of Andrographis paniculata, 90g of Cymbidium japonica, 80g of Maihecao two-leaf, and 150g of Sandianjincao as raw materials. The current extraction method is to add water and decoct twice, each time for 2-3 hours, and combine The decoction is filtered, concentrated into a thick paste, granulated, dried, compressed into 1000 tablets, coated with sugar, and can resist viruses. [0003] In the prior art, there is no report on the use of microwave technology in the extraction and preparation of plant compositions containing Andrographis paniculata. However, the method of decocting in water is rough, backward, and has many impurities, which leads to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61P35/00
Inventor 赵明亮
Owner NANJING ZHENGLIANG MEDICAL TECH
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