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Preparation method of and application of compound Haqing injection in preparing preparation for atomizing and rectal administration

A compound clam green and rectal administration technology, which is applied in aerosol delivery, pharmaceutical formulations, drug combinations, etc., can solve the problems of secondary infection, long disintegration time, low dissolution rate, etc., and achieve convenient use and significant curative effect , high compliance effect

Inactive Publication Date: 2016-02-03
耿福能
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although the clinical curative effect of Compound Haqing Injection is definite, due to its complex composition, it is easy to cause local induration after intramuscular injection, even swelling and pain, secondary infection, and frequent injection can easily lead to gluteal muscle contracture syndrome
In addition, there may be adverse reactions such as allergies, especially in children with higher safety risks
However, the traditional oral preparations of traditional Chinese medicine have problems such as long disintegration time, low dissolution rate, poor absorption, low intestinal first-pass effect and low bioavailability after taking, which affect the efficacy of the drug and directly affect the therapeutic effect.
In addition, the production process of conventional oral solid Chinese medicine preparations is complicated and the production cost is high, thus increasing the cost of medication for patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] The preparation method of embodiment 1 compound Haqing injection

[0026] Weigh 8kg of toad, 10kg of astragalus, 4kg of ginkgo, 5kg of bitter almond, 5kg of aster, 3kg of peucedanum, 3kg of schisandra, 1kg of aconite, and 1kg of black pepper, crush ginkgo and bitter almond, and crush the 6 herbs except toad, Mix the processed nine medicinal herbs, add water and decoct 3 times, the amount of water added is 6 times, 3 times, and 3 times the total weight of the dry medicinal materials, and the decocting time is 3 hours, 2 hours, and 1 hour respectively, and the three extractions are combined After the solution is filtered, concentrated to a relative density of 1.1 (measured at 80°C), then add the A component solution in the natural clarifier ZTC1+1Ⅱ with 15% of the volume of the liquid medicine, stir and stand for a period of time, and then add the B component solution , the temperature of the liquid medicine is kept at 80°C, after standing for 8 hours, filter the plate an...

Embodiment 2

[0028] The preparation method of embodiment 2 compound Haqing injection

[0029] Weigh 4kg of toad, 5kg of astragalus, 2kg of ginkgo, 2.5kg of bitter almond, 2.5kg of aster, 1.5kg of peucedanum, 1.5kg of schisandra, 0.5kg of aconite, and 0.5kg of black pepper, crush ginkgo and bitter almond, and 6 Crush the medicinal materials of different flavors respectively, mix the processed nine medicinal materials, add water to decoct once, the amount of water added is 10 times of the total weight of the dry medicinal materials, and the decoction time is 5 hours, filter the extract, and concentrate to a relative density of 1.05 (measured at 82°C), then add 8% of the liquid volume of the natural clarifier ZTC1+1Ⅱ component A solution, stir and let stand for a period of time, then add 4% of the B component solution, the temperature of the liquid is kept at After standing at 100°C for 10 hours, plate and frame filter, add absolute ethanol to the filtrate, adjust the alcohol content of the l...

Embodiment 3

[0031] The preparation method of embodiment 3 compound Haqing injection

[0032] Weigh 800g toad, 1000g astragalus, 400g ginkgo, 500g bitter almond, 500g aster, 300g Peucedanum, 300g schisandra, 100g aconite, 100g black pepper, crush ginkgo and bitter almond, crush the 6 medicinal materials except toad, Mix the processed nine medicinal materials, add water and decoct twice, the amount of water added is 8 times and 2 times the total weight of the dry medicinal materials, and the decoction time is 3 hours and 1 hour respectively, the secondary extracts are combined, filtered and concentrated to The relative density is 1.15 (measured at 85°C), add 20% of the liquid volume of the natural clarifier ZTC1+1Ⅱ in the A component solution, stir and let stand for a period of time, then add 10% of the B component solution, the temperature of the liquid Keep it at 90°C, after standing for 6 hours, filter with a plate frame, add absolute ethanol to the filtrate, adjust the alcohol content o...

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Abstract

The invention provides a preparation method of and application of a compound Haqing injection in preparing a preparation for atomizing and rectal administration . The preparation is a combination of the compound Haqing injection and one or more of ambroxol, potassium dehydroandrogrpholide succinate, furosemide and dexamethasone, is mainly used for atomizing and rectal administration and has remarkable effect on treating respiratory tract diseases such as respiratory tract infection, bronchial asthma and bronchitis.

Description

technical field [0001] The invention relates to the application and preparation method of a compound traditional Chinese medicine, in particular to the application and preparation method of compound Haqing injection in the preparation of atomized and rectal administration preparations, belonging to the field of traditional Chinese medicine preparations. Background technique [0002] The main components of compound clam green are toad, astragalus, ginkgo, bitter almond, aster, peucedanum, schisandra, aconite, black pepper, etc. Among them, astragalus has the effect of nourishing qi and strengthening the surface, and toad, bitter almond, and aster have the effect of relieving cough and asthma. Peucedanum, schisandra, and aconite have the effect of warming and resolving phlegm. Especially toads contain catecholamines and indole alkyls, which can slow down the heart rate, strengthen the heart, and have hormone-like anti-inflammatory effects. It is widely used clinically for cou...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61K36/736A61K9/12A61K9/72A61K9/00A61P11/06A61P11/00A61P31/00A61K35/65A61K31/365A61K31/137A61K31/341A61K31/573
Inventor 耿福能
Owner 耿福能
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