Antibacterial peptide plectasin film-forming agent and preparation method and application thereof

A technology of phlegmycin and film-forming agent, applied in the field of bioengineering, can solve the problems of low encapsulation rate, high cost, poor stability, etc., and achieve the effects of high encapsulation rate, good infection and good stability

Inactive Publication Date: 2016-02-03
GUANGDONG HINAPHARM PHARMA CO LTD
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] In view of the above-mentioned deficiencies in the prior art, the object of the present invention is to provide a film-forming agent of antimicrobial peptide plectasin and its preparation method and application, aiming at solving the problems of low encapsulation efficiency, poor stability and high cost problem

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  • Antibacterial peptide plectasin film-forming agent and preparation method and application thereof
  • Antibacterial peptide plectasin film-forming agent and preparation method and application thereof
  • Antibacterial peptide plectasin film-forming agent and preparation method and application thereof

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Embodiment Construction

[0039] The present invention provides an antimicrobial peptide plectasin film-forming agent and its preparation method and application. In order to make the purpose, technical scheme and effect of the present invention clearer and clearer, the present invention will be further described in detail below. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention.

[0040] The invention discloses a preparation method of an antimicrobial peptide plectasin film-forming agent, which comprises the steps of:

[0041] A, the construction of the expression vector of the antimicrobial peptide plectasin

[0042] Inserting the plectasin gene sequence into the expression vector of Pichia pastoris to obtain a recombinant plasmid;

[0043] The recombinant plasmid was subjected to restriction enzyme digestion and then electroporated into Pichia pastoris, and then cultured in Pichia pastoris with medi...

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Abstract

The invention discloses an antibacterial peptide plectasin film-forming agent and a preparation method and application thereof. The antibacterial peptide plectasin film-forming agent prepared from antibacterial peptide plectasin is simple in technology, high in encapsulation efficiency and stability and low in cost, can be produced on a large scale and is capable of playing a role in protection directly to kill bacteria rapidly and prevent further infection of inflammation, thereby treating infection effectively. The antibacterial peptide plectasin film-forming agent has no significant difference in influence on dairy cow milk yield, milk protein content, milk sugar content, butter-fat percentage and nonfat milk solid content and has notable prevention effect when being applied to subclinical mastitis of dairy cows.

Description

technical field [0001] The invention relates to the technical field of bioengineering, in particular to a film-forming agent of the antimicrobial peptide mycelia and its preparation method and application. Background technique [0002] Bovine Mastitis (Bovine Mastitis) is one of the three major diseases that harm the dairy farming industry. It mainly causes a decrease in milk production, milk quality and production performance of dairy cows. It is reported that the incidence of mastitis in foreign dairy cows is 20% to 60%, while the incidence in China is as high as 30% to 70%. The average incidence of clinical mastitis is 21% to 23%, and the incidence of invisible mastitis in cows It is as high as 50%~70%. Annual losses caused by mastitis are as high as 2 billion U.S. dollars in the United States, 267 million pounds in the United Kingdom, 500 million U.S. dollars in Japan, and 1 billion euros in Germany. In my country, the annual loss due to mastitis is about 1200-3600 yua...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/16A61K9/70A61K47/38A61P15/14A61P31/04
Inventor 叶滔周玉岩逯佩凤闫凯冯蓓代珍青
Owner GUANGDONG HINAPHARM PHARMA CO LTD
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