Intestinal metagenome feature as type-2 diabetes acarbose curative effect selection marker

Abstract

The invention discloses an intestinal metagenome feature as a type-2 diabetes acarbose curative effect selection marker. The intestinal microorganism metagenome feature is the bacteroides intestinal pattern. By using the intestinal pattern concept for the first time, it is found that type-2 diabetes patients with different intestinal parasitic bacterium groups make remarkably different treatment responses to diabetes hypoglycemic drugs acarbose, and therefore before the drugs are used, the intestinal patterns of the patients can be distinguished, people with the optimal curative effect are selected, and whether acarbose is suitable for conducting diabetes treatment on the individual type-2 diabetes patient or not is judged. In addition, the conventional distinguishing of the intestinal patterns is achieved through DNA sequencing of parasitic bacteria in excrement or PCR amplifying, and the intestinal patterns can be well distinguished under the condition of a base line through bile acid composition especially secondary bile acid; the intestinal patterns can be identified through markers in blood, and the marker becomes a marker for diagnosis.

Description

technical field [0001] The present invention specifically relates to the use of a metagene feature of intestinal microorganisms as a marker for screening the efficacy of acarbose in type 2 diabetes. Background technique [0002] At present, there is no judgment of drug efficacy in the field of type 2 diabetes treatment, and there is no type diagnosis before treatment. According to the pathophysiological mechanism of type 2 diabetes, it is mainly insulin resistance and insulin secretion defect. Although there are drugs for insulin resistance and insulin secretion defect in the field of type 2 diabetes treatment, there is no scientific, simple and feasible method for the type diagnosis of insulin resistance or insulin secretion defect. [0003] The existing clinically feasible solution is to measure the patient's BMI, waist circumference and insulin level. Insulin resistance can be judged if the BMI and waist circumference exceed the Chinese standard, or the HOMAIR value is ...

AI Technical Summary

Problems solved by technology

However, no effective solution for targeted therapy of type 2 diabetes has been found so far

There are many treatment options for type 2 diabetes, and patients respond differently, which is one of the reasons for the low rate of blood sugar control in type 2 diabetes

However, although intestinal parasitic flora is also considered to be an important medium involved in the metabolism of drugs in the human body [Haiser, H.J. and P.J. Turnbaugh, Isittimeforametagenomicbasisoftherapeutics? Science, 2012.336(6086):p.1253-5], there is currently no clinical trial evidence to prove

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