Ionization method and ionization device

An ionization and ion source technology, applied in the field of mass spectrometry, can solve problems such as complex sample analysis steps, and achieve the effects of wide application range, easy implementation, and remarkable practicability

Active Publication Date: 2016-02-24
SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these atmospheric pressure ionization methods simplify the analysis steps, these ionization methods still need the assistance of auxiliary gas, laser, voltage, etc., which complicates the analysis steps of the sample.

Method used

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  • Ionization method and ionization device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0070] Will figure 1 The flame ionization device shown is combined with a mass spectrometer (the mass analyzer is Fourier transform ion cyclotron resonance), and for the liquid sample methyl salicylate (Methylsalicylate, MW=152): Perform mass spectrometry:

[0071] Use n-butane as fuel to make it burn to produce flame 1;

[0072] Spray a sample of methyl salicylate over or around the flame;

[0073] Keep the flame burning continuously, and the mass analyzer is always in the collection state;

[0074] image 3 For the mass spectrum obtained by image 3 The mass spectrum shown can be seen: the ion peak related to methyl salicylate appears in the spectrum [M+H] + =153, indicating that the device and method of the present invention can achieve good ionization efficiency.

Embodiment 2

[0076] Will figure 1 The ionization device shown is combined with a mass spectrometer (the mass analyzer is Fourier transform ion cyclotron resonance), and for the liquid sample dimethyl sulfoxide (Dimethylsulfoxide, MW=78): Perform mass spectrometry:

[0077] Use n-butane as fuel to make it burn to produce flame 1;

[0078] Keep containers of DMSO open near flames;

[0079] Keep the flame burning continuously, and the mass analyzer is always in the collection state;

[0080] Figure 4 For the mass spectrum obtained by Figure 4 The mass spectrum shown can be seen: the ion peak related to dimethyl sulfoxide appears in the spectrum [2M+H] + =157, indicating that the device and method of the present invention can achieve good ionization efficiency.

Embodiment 3

[0082] Will figure 1 The ionization device shown is combined with a mass spectrometer (the mass analyzer is Fourier transform ion cyclotron resonance), and for the liquid sample diethylene glycol dimethyl ether (2-Methoxyethylether, MW=134): Perform mass spectrometry:

[0083] Use n-butane as fuel to make it burn to produce flame 1;

[0084] Keep the container of diethylene glycol dimethyl ether open near the flame;

[0085] Keep the flame burning continuously, and the mass analyzer is always in the collection state;

[0086] Figure 5 For the mass spectrum obtained by Figure 5 The mass spectrum shown can be seen: the ion peak [M+H] related to diethylene glycol dimethyl ether appears in the spectrum + =135, indicating that the device and method of the present invention can achieve good ionization efficiency.

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PUM

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Abstract

The invention discloses an ionization method and an ionization device. The ionization method comprises an ion source, a sample, and a mass spectrum feeding channel, and is characterized in that the ion source is a flame. By using a flame as an ion source, the ionization technology is easy to implement and simple in operation, the analysis cost is reduced greatly, the ionization technology is of high compatibility and can meet the ionization resolution temperature requirement of compounds of different molecular sizes, the ionization efficiency is high for gaseous, liquid and solid samples and actual samples, the ionization technology is of high sensitivity, actual samples can be analyzed directly, substances such as polar, highly polar, non-polar and metal organic compounds can be well ionized, and the ionization technology has a wide application range, can be used together with a portable mass spectrometry to make natural in-situ analysis more convenient and is of significant practical value.

Description

technical field [0001] The invention relates to an ionization method and device, belonging to the technical field of mass spectrometry. Background technique [0002] Mass spectrometry (MS) is a powerful tool for the analysis of complex mixtures, providing information about the molecular weight and chemical structure of the analyte. In recent years, with the continuous innovation and improvement of ionization technology and mass analyzers, mass spectrometry has become one of the fastest-growing analytical technologies. At present, mass spectrometry technology is widely used in chemistry and chemical engineering, biology and life science, medicine, pharmacy, Applications in environmental protection and other fields are becoming more and more extensive. [0003] Common ionization methods include electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and matrix-assisted laser desorption ionization (MALDI) commonly used in solids. The above-mentioned io...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01J49/18H01J49/26
CPCH01J49/18H01J49/26G01N27/623
Inventor 郭寅龙刘小潘王昊阳涂奇奇
Owner SHANGHAI INST OF ORGANIC CHEM CHINESE ACAD OF SCI
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