Traditional Chinese medicine extract composition and application thereof to preparation of medicines for leukemia treatment

A technology of extract and traditional Chinese medicine, which is applied in the field of traditional Chinese medicine preparation, can solve the problems of high price, ineffective effect, and many side effects, and achieve the effect of inhibiting proliferation

Inactive Publication Date: 2016-03-02
YUYAO WANZHEN HARDWARE FACTORY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the high cost of interferon treatment, large doses have many side effects (such as reduced mobility, decreased governance, etc.), the current domestic application is not yet common
[0005] Some of the above-mentioned drugs have strong toxicity, and have a killing effect on normal cell fluid while treating leukemia, some have no obvious effect, and some have good effect but are expensive

Method used

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  • Traditional Chinese medicine extract composition and application thereof to preparation of medicines for leukemia treatment

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] The traditional Chinese medicine combination extract is prepared from the following raw materials: barbata barbata 25kg, Polygonatum odoratum 16kg, rush grass 15kg, saffron 12kg.

[0022] The preparation method of the above-mentioned Chinese medicine combination extract, the specific preparation steps are as follows:

[0023] (1) Clean each raw material respectively, and dry it under natural environment, so that the water content of each raw material is maintained at 8 to 12%, weigh them respectively according to the proportioning ratio, grind them into 50 mesh medicinal materials with a pulverizer respectively, and then well mixed;

[0024] (2) Add 10 times of the raw materials to the above-mentioned mixed medicinal materials and soak in water for 6 hours, extract the volatile oil by steam distillation, the extraction time is 3 hours, and the extraction times are 4 times, collect the volatile oil to obtain extract A;

[0025] (3) the extract A obtained by step (2) is ...

Embodiment 2

[0028] The traditional Chinese medicine combination extract is prepared from the following raw materials: barbata 30kg, polygonatum 14kg, rush 18kg, saffron 11kg.

[0029] The preparation method of the above-mentioned Chinese medicine combination extract, the specific preparation steps are as follows:

[0030] (1) Clean each raw material respectively, and dry it under natural environment, so that the water content of each raw material is maintained at 8 to 12%, weigh them respectively according to the proportioning ratio, grind them into 50 mesh medicinal materials with a pulverizer respectively, and then well mixed;

[0031] (2) Add 11 times of the raw materials to the above-mentioned mixed medicinal materials and soak for 7 hours, extract the volatile oil by steam distillation, the extraction time is 3.5 hours, and the number of extractions is 4 times, collect the volatile oil to obtain extract A;

[0032] (3) The extract A obtained in step (2) is 95% ethanol as a solvent b...

Embodiment 3

[0035] The traditional Chinese medicine combination extract is prepared from the following raw materials: barbata barbata 35kg, polygonatum odoratum 12kg, rush grass 20kg, saffron 10kg.

[0036] The preparation method of the above-mentioned Chinese medicine combination extract, the specific preparation steps are as follows:

[0037] (1) Clean each raw material respectively, and dry it under natural environment, so that the water content of each raw material is maintained at 8 to 12%, weigh them respectively according to the proportioning ratio, grind them into 50 mesh medicinal materials with a pulverizer respectively, and then well mixed;

[0038] (2) Add 12 times of the raw materials to the above-mentioned mixed medicinal materials and soak in water for 8 hours, extract the volatile oil by steam distillation, the extraction time is 4 hours, and the number of times of extraction is 4 times, and the volatile oil is collected to obtain extract A;

[0039](3) the extract A obta...

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Abstract

The invention discloses a traditional Chinese medicine extract composition and application thereof to preparation of medicines for leukemia treatment. The traditional Chinese medicine extract composition is prepared from herba scutellariae barbatae, radix polygonati officinalis, Juncus effusus and stigma croci by steps of processing, steam distillation, alcohol extraction and macroporous resin absorption. The traditional Chinese medicine extract composition serves as an active ingredient of a pharmaceutical composition accepting additives pharmaceutically to treat leukemia. The traditional Chinese medicine extract composition is purified by distillation, alcohol extraction and macroporous resin absorption, leukemia treatment extract preparation is researched, and extracts with leukemia treatment activity are obtained by separation and prepared for leukemia treatment. The traditional Chinese medicine extract composition is capable of inhibiting proliferation of leukemia cells (HL-60 cells) and inducing apoptosis of the leukemia cells (HL-60 cells), so that the traditional Chinese medicine extract composition can be used for leukemia treatment.

Description

technical field [0001] The invention relates to the technical field of preparation of traditional Chinese medicines, in particular to a combination extract of traditional Chinese medicines and its application in the preparation and treatment of leukemia. Background technique [0002] Leukemia is a malignant disease that originates from the hematopoietic system and is characterized by the production and accumulation of a large number of immature and abnormal white blood cells in the bone marrow or other hematopoietic tissues. From the perspective of form, most leukemia cells are immature and abnormally morphological white blood cells; in terms of function, leukemia cells have the same characteristics as tumor cells: leukemia cells are tumorous proliferation, which cannot be controlled, and often leads to the inhibition and failure of bone marrow hematopoietic function. It can cause anemia, neutropenia and thrombocytopenia in patients. Leukemic cells can infiltrate various tis...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8969A61P35/02
CPCA61K36/539A61K9/1652A61K9/2059A61K36/88A61K36/8969A61K2236/15A61K2236/331A61K2236/333A61K2236/39A61K2236/55
Inventor 沈婉珍
Owner YUYAO WANZHEN HARDWARE FACTORY
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