Ranunculi ternati radix extract and application thereof

A kind of cat's claw, extract technology, applied in the field of traditional Chinese medicine cat's claw extract

Inactive Publication Date: 2016-03-23
DALIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But up to now, there is no relevant literature report on the antidepressant activity of cat's claw extract

Method used

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  • Ranunculi ternati radix extract and application thereof
  • Ranunculi ternati radix extract and application thereof
  • Ranunculi ternati radix extract and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment 1 cat's claw extract

[0015] Mince 100g of cat's claw grass, add water of 8 times the weight of cat's claw grass, reflux extraction 3 times, each time for 2 hours, combine the filtrate, concentrate under reduced pressure to an extract with a relative density of 1.05-1.15 at 50-70°C, Freeze-dried to obtain dry extract, crushed to obtain 11.6g of cat's claw extract.

Embodiment 2

[0016] Example 2 Cat's Claw Extract Effects on the Spontaneous Activity of Mice

[0017] Take male ICR mice, weighing about 20g, and randomly group them into groups. After two days of adaptive feeding, 1 hour before the first administration, put the mice in the mouse autonomous activity measuring instrument for 2 minutes, and the mice will move autonomously within 4 minutes after the measurement. , then measure the autonomous activity of the mouse after the first administration 1h, then continue administration for 7 days, once a day, the dosage is respectively the cat's claw extract 5g / kg and 10g / kg prepared in embodiment 1; 7 Three days later, the mice's autonomous activities were measured again, and the autonomous activity data before administration, after 1 hour of administration and after 7 days of administration were compared. There was no significant difference in the number of voluntary activities and standing times of the mice, indicating that the extract of cat's claw...

Embodiment 3

[0018] Example 3 Cat's Claw Extract Effects on Mouse Tail Suspension Experiment

[0019] Male ICR mice, weighing about 20 g, were randomly divided into groups. After 2 days of adaptive feeding, the animals in each group underwent 6-min tail-suspension adaptive training 24 hours before the formal test. Each group was given continuous intragastric administration for 7 days, once a day, and the dosages were 25 mg / kg and 50 mg / kg (prepared in Example 1), respectively. The model group was given the same amount of normal saline, and the tail hanging upside down was measured after 7 days of administration. Mice, immobility time within 4min. The environment was quiet during the experiment, and the time and experimenters were fixed. The specific results are as follows:

[0020]

[0021] * and ** represent P<0.05 and 0.01 compared with the model group, respectively

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Abstract

The invention belongs to the field of traditional Chinese medicines and particularly relates to a ranunculi ternati radix extract and an application thereof. The ranunculi ternati radix extract is a polar solvent extract, wherein an aqueous or polar organic solvent extract of ranunculi ternati radix has a depression treating effect. According to the novel application of the ranunculi ternati radix extract to preparation of depression treating drugs or food, the drugs or food has the remarkable effect on preventing and treating depression caused by various reasons.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to an extract of the traditional Chinese medicine cat's claw and its application. Background technique [0002] Depression is characterized by persistent low mood and cognitive dysfunction, including restlessness, anhedonia, sleep disturbance, guilt, and recurrent suicidal thoughts. The main reason is that the level of specific neurotransmitters such as central norepinephrine, serotonin, and dopamine is too low and the receptor function is low, which has the characteristics of high incidence and wide age of onset. Depression not only brings patients Mental loss, but also a heavy financial burden on patients. As the pace of life in modern cities continues to accelerate, people are under increasing pressure, and the incidence of depression is also increasing year by year. At present, depression has become a mental disease that seriously endangers human physical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P25/24A23L33/105
CPCA61K36/71A23V2002/00A23V2200/322A23V2250/21
Inventor 唐玲占希蔡柯
Owner DALIAN UNIV
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