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Peppermint oil hydrogel plaster substrate and preparation method thereof

A hydrogel patch and peppermint oil technology, applied in the field of medicine, can solve problems such as poor use effect, inability to absorb drug ingredients in the body, skin allergies, etc., and achieve large drug loading, good transdermal absorption effect, and high absorption rate Effect

Inactive Publication Date: 2015-04-22
CHUXIONG YUNCUI BIOLOGICAL SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the currently used patch matrix cannot allow the body to absorb the drug ingredients well, and the use effect is poor. There are also unsafe problems such as skin allergies during use.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Take by weight 10 kilograms of sodium polyacrylate, 3 kilograms of polyvinylpyrrolidone, 0.5 kilogram of cross-linked polyvinylpyrrolidone, 50 kilograms of glycerol, 20 kilograms of propylene glycol and 0.1 kilogram of aluminum glycinate and mix evenly, then add 100 kilograms of pure water, Then heated to 40°C and stirred for 60 minutes to obtain the first intermediate material; then weighed 2 kg of polyvinyl alcohol in parts by weight and added to 20 kg of pure water, heated to 80°C until completely dissolved to obtain the second intermediate material; The first intermediate material is mixed with the second intermediate material and stirred evenly to obtain the third intermediate material; in addition, 1 kg of ethanol, 0.01 kg of peppermint oil, 0.19 kg of tartaric acid, 0.3 kg of lactic acid and ethylenediaminetetraacetic acid are weighed in parts by weight 0.01 kg was added to 30 kg of purified water for dissolving, and stirred evenly to obtain the fourth intermediat...

Embodiment 2

[0028] Take by weight 9 kilograms of sodium polyacrylate, 3 kilograms of polyvinylpyrrolidone, 0.3 kilogram of cross-linked polyvinylpyrrolidone, 45 kilograms of glycerol, 15 kilograms of propylene glycol and 0.1 kilogram of aluminum glycinate and mix uniformly, then add 94 kilograms of pure water, Then heated to 40°C and stirred for 60 minutes to obtain the first intermediate material; then weighed 2 kg of polyvinyl alcohol in parts by weight and added it to 18 kg of pure water, heated to 80°C until completely dissolved to obtain the second intermediate material; The first intermediate material and the second intermediate material are mixed and stirred evenly to obtain the third intermediate material; in addition, weigh 0.7 kg of ethanol, 0.008 kg of peppermint oil, 0.15 kg of tartaric acid, 0.2 kg of lactic acid and ethylenediaminetetraacetic acid 0.008 kg was added to 28 kg of purified water for dissolving, and stirred evenly to obtain the fourth intermediate material; then ...

Embodiment 3

[0030] Take by weight 10 kilograms of sodium polyacrylate, 4 kilograms of polyvinylpyrrolidone, 0.7 kilogram of cross-linked polyvinylpyrrolidone, 55 kilograms of glycerol, 25 kilograms of propylene glycol and 0.4 kilogram of aluminum glycinate and mix uniformly, then add 107 kilograms of pure water, Then heated to 40°C and stirred for 60 minutes to obtain the first intermediate material; then weighed 3 kg of polyvinyl alcohol in parts by weight and added it to 21 kg of pure water, heated to 80°C until completely dissolved to obtain the second intermediate material; The first intermediate material and the second intermediate material are mixed and stirred evenly to obtain the third intermediate material; in addition, 1.2 kg of ethanol, 0.012 kg of peppermint oil, 0.25 kg of tartaric acid, 0.4 kg of lactic acid and ethylenediaminetetraacetic acid are weighed in parts by weight 0.012 kg was added to 32 kg of purified water for dissolving, and stirred evenly to obtain the fourth i...

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Abstract

The invention relates to a peppermint oil hydrogel plaster substrate and a preparation method thereof, belonging to the technical field of medicine. The plaster substrate is prepared from the following raw materials in parts by weight: 8-12 parts of sodium polyacrylate, 1-3 parts of polyvinyl alcohol, 2-5 parts of polyvinylpyrrolidone, 0.2-0.8 part of cross-linked polyethylene pyrrolidone, 40-60 parts of glycerol, 10-30 parts of propanediol, 0.5-1.5 parts of ethanol, 0.005-0.015 part of peppermint oil, 0.05-0.5 part of aluminum glycine, 0.1-0.3 part of tartaric acid, 0.1-0.5 part of lactic acid, 0.005-0.015 part of ethylenediamine tetraacetic acid and 120-180 parts of water. The invention can enable the organisms to have favorable transdermal absorption effect and high absorptivity for medicines, and to be safe and reliable when in use.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a peppermint oil hydrogel patch matrix and a preparation method thereof. Background technique [0002] The transdermal drug delivery system is a drug dosage form that uses the skin as a drug delivery channel. It has the advantages of constant and long-lasting release of drugs into the systemic circulation through the skin, avoiding drug decomposition in the digestive tract, and reducing damage to the stomach and liver. Among the dosage forms for transdermal administration, there are ointments, black plasters, white plasters, pastes, plasters, etc. In the above dosage forms, it is often necessary to select a suitable matrix as a drug carrier in order to exert a therapeutic effect. However, the currently used patch matrix cannot allow the body to absorb the drug ingredients well, and the use effect is poor. There are also unsafe problems such as skin allergies during u...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K47/44
Inventor 秦大良陈建文
Owner CHUXIONG YUNCUI BIOLOGICAL SCI & TECH
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