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Application of a Class of Bis-Indolylmethane Compounds in Pesticides

A technology of bis-indolylmethane and compounds, which is applied in the field of pesticides, can solve unseen problems and achieve the effect of expanding the scope of use

Active Publication Date: 2018-01-26
INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although various activities of bis-indolylmethane have been reported in the literature, there is no report on the application of pesticides, especially anti-phytopathogenic bacteria

Method used

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  • Application of a Class of Bis-Indolylmethane Compounds in Pesticides

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Example 1: 3,3'-(phenylmethylene)-diindole's antibacterial activity assay

[0015] Accurately weigh a certain amount of test sample 3,3'-(phenylmethylene)-diindole, dissolve it with DMSO to make a mother solution, then add the mother solution or an equal volume of DMSO to the sterilized PDA medium ( The final concentration of DMSO was 0.1%), mixed and shaken, and poured into a sterile petri dish to make a PDA drug-containing plate (the final concentration of the sample was 10 μg / mL), and the PDA plate containing only DMSO was used as the solvent control, without solvent or The PDA plate of the medicinal solution was used as a blank control. Use a puncher with an inner diameter of 5 mm to take the plate from the edge of the activated colony, pick the plate with an inoculation needle and put it on the PDA drug-containing plate, and cultivate it in a constant temperature incubator at 25 °C. When the colony of the blank control group grew to nearly full plate, the diameter...

Embodiment 2

[0020] Embodiment 2: 3,3'-((4-nitrophenyl) methylene)-diindole antibacterial activity assay

[0021] According to the antibacterial activity assay experiment described in Example 1, only 3,3'-(phenylmethylene)-diindole is replaced by 3,3'-((4-nitrophenyl)methylene )-diindole.

[0022] After testing, when the compound 3,3'-(phenylmethylene)-diindole was at a concentration of 10 μg / mL, it was effective against Sclerotinia sclerotiorum, Botrytis cinerea, Botrytis cinerea, Leaf spot of corn, Bakanae oryzae, The inhibition rates of wheat sheath blight and rice blast were 72.17%, 62.77%, 57.60%, 43.52%, 43.52% and 51.20%, respectively.

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Abstract

The invention discloses application of a diindolylmethane compound in pesticides, in particular relates to the application in the aspects such as resistance to sclerotinia sclerotiorum, gray mold, sheath blight, leaf spot, bakanae disease, rice blast and the like. The compound structure is represented in the following general formula (I). The diindolylmethane compound can effectively inhibit multiple phytopathogens, extend the application of diindolylmethane compounds, and has a better application prospect in plant disease control.

Description

technical field [0001] The invention belongs to the technical field of pesticides, and in particular relates to the application of a class of bis-indolylmethane compounds in pesticides, especially the application of pesticides against plant pathogenic bacteria. Background technique [0002] Plant diseases are one of the main factors affecting agricultural production. At present, the prevention and control of plant diseases in various countries in the world mainly uses chemical agents. The resistance of plant pathogens to fungicides is one of the main problems in the chemical control of plant diseases. Under the long-term selection of single agents, the resistance of plant pathogens is becoming more and more serious and common. Therefore, new low-resistance agents are constantly being developed. Species are a challenge in pesticide research. [0003] Bis-indolylmethane compounds exist in a variety of marine organisms and bacterial metabolites, and have physiological activiti...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/38A01P1/00A01P3/00
CPCA01N43/38
Inventor 刘飞冯煦徐曙王碧王奇志单宇印敏管福琴陈雨赵兴增王鸣赵友谊王雪莉
Owner INST OF BOTANY JIANGSU PROVINCE & CHINESE ACADEMY OF SCI
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