2 results about "Bis indole" patented technology

The application discloses a method for preparing a heterocyclic bridged double indole derivative through iodine-catalyzed cyclization isomerization of a ynamine compound. The method does not need to use a transition metal and an acid catalyst, and can be performed only under iodine catalysis, has high catalytic efficiency, does not need any anhydrous operation, has moderate reaction conditions, is simple, has moderate yield, has a wide substrate range, realizes chemoselectivity and controllable synthesis of a series of functionalized indole derivatives.

This invention discloses an N-N axial chiral phase-transfer catalyst, its synthesis method, and its applications, belonging to the field of asymmetric catalytic synthesis technology. Using chiral 2,4-pentanediol and N-Boc-indolephenol as starting materials, this invention efficiently constructs an N-N axial chiral biscarbazole cyclic ether skeleton through a five-step reaction involving Mitsunobu etherification, deBoc protection, PIDA oxidative cyclization, radical bromoxymethylation, and intramolecular quaternization. This method eliminates the need for complex chiral resolution and noble metal coupling, employs mild reaction conditions, uses readily available and inexpensive starting materials, achieves high overall yield, and yields a product with an axial chirality ee value ≥98%. The resulting catalyst possesses excellent conformational rigidity, chiral induction ability, and phase-transfer performance, exhibiting broad substrate applicability. It also possesses bisindole ring bioactivity, making it widely applicable in asymmetric catalytic synthesis in pharmaceuticals, fine chemicals, and other fields, and providing new directions for the development of antibacterial and antitumor biomaterials.