84 results about "Bis indole" patented technology

Compounds of Formula I, commonly referred to as bis-indole pyrroles, including isolated naturally-occurring compounds, synthetic and semi-synthetic derivatives thereof having antimicrobial properties and to antimicrobial compositions that include one or more of bis-indole pyrroles and their derivatives or analogs having antimicrobial properties are disclosed. Pharmaceutical compositions comprising such compounds and methods of treating bacterial infections with the disclosed compounds or the disclosed pharmaceutical compositions are also disclosed.

The present invention relates to an organic semiconductor element that comprises multiple layers. One or more layers may include compounds that can function as light absorbers, charge transporting materials, and / or as a dopant.

Disclosed are novel compounds which inhibit RSK, methods of making such compounds and pharmaceutical compositions comprising such compounds. Also disclosed are methods of treating RSK2 regulated disorders using compounds of the invention.

The invention relates to a 2,2-di(1H-indole-3-yl)-2H-acenaphthene-1-ketone compound and a preparation method thereof, and belongs to the technical field of organic chemical synthesis. The preparation method comprises the following steps: reacting in an anhydrous alcohol solvent in the presence of a sulfonic acid compound by taking acenaphthequinone and an indole compound as raw materials, cooling a reaction liquid to reach a room temperature after the reaction is completely carried out; adding distilled water into the reaction liquid so as to separate out yellow solid powder; carrying out suction filtration on the yellow solid powder and washing the yellow solid powder with absolute ethyl alcohol; and carrying out vacuum drying so as to obtain the 2,2-di(1H-indole-3-yl)-2H-acenaphthene-1-ketone compound. The method carried out by taking the anhydrous alcohol as a solvent and the sulfonic acid compound as a catalyst is simple and easy in raw material obtainment, low equipment requirement, moderate in reaction condition, good in catalytic effect as well as simple and convenient to operate. The yield of the obtained compound can reach above 97%; and the purity of the obtained compound can reach above 99%. The 2,2-di(1H-indole-3-yl)-2H-acenaphthene-1-ketone compound, the structure of which is authenticated by the nuclear magnetic resonance, is suitable for industrial production.

Disclosed herein are methods for synthesizing biologically active bis-heterocyclic compounds, e.g. bis-indoles. In particular, methods for making Soritin compounds such as Soritin B, bis-(1H-indol-3-yl)-acetic acid methyl ester, Soritin C, bis-2,2-(1-methyl-indol-3-yl) acetic acid methyl ester, Soritin D, bis-2,2-(1-methyl-indol-3-yl) acetic acid and Soritin compositions comprising the Soritin compounds are disclosed. Also disclosed are pharmaceutical formulations comprising the Soritin compounds and Soritin compositions.

Relating to the field of chemical industry, the invention discloses a method and a device for removing indole from beta-methylnaphthalene. Structurally, the device comprises a distillation kettle and azeotropic distillation tower. An overflow recovery baffle is disposed at a tower top recovery outlet of the azeotropic distillation tower. A tower top recovery pipeline is connected to a cooler, a separation tank A and a separation tank B in order. The method includes: adding a mixture of the raw material beta-methylnaphthalene and an azeotropic agent into the distillation kettle, controlling the temperature of the kettle bottom at 145-147DEG C; maintaining the azeotropic distillation tower at a pressure of -70-90kpa and the tower top at a temperature of 140-142DEG C; carrying out intermittent azeotropic distillation separation, subjecting the evaporated liquid to cooling by the tower top cooler and internal reflux; and subjecting the azeotropic distillation tower top recovered liquid to cooling by the cooler, then leaving the liquid to flow into the separation tank A and the separation tank B in order, performing standing layering, and recovering the product. By means of the method and the device, after distillation separation, the content of the raw material beta-methylnaphthalene can be increased to over 98%, and the indole content decreased to an undetectable degree. The device and the method provided in the invention are simple and are easy to operate.

Disclosed is an organic electroluminescent device (organic EL device) that is improved in the luminous efficiency, fully secured of the driving stability, and of a simple structure. The organic EL device comprises a light-emitting layer between an anode and a cathode piled one upon another on a substrate and the said light-emitting layer comprises (A) a phosphorescent dopant whose emission peak wavelength is longer than 600 nm and (B) a host material. The host material contains at least two kinds of compounds selected from two or more kinds of derivatives included in (b1) N-substituted indolocarbazole derivatives, (b2) derivatives of 8-hydroxyquinoline aluminum complex, and (b3) bisindolocarbazole derivatives.