7 results about "Bis indole" patented technology

The invention discloses a bisindole compound as well as a synthesis method and anti-tumor application thereof. The molecular structure of the bisindole compound is shown in the specification. The bisindole compound XQ-010 has the remarkable effects that the bisindole compound XQ-010 can be used as an IL-6 / STAT3 signal channel regulator for tumor treatment, particularly has unique advantages in the aspect of inhibiting tumor growth and metastasis based on the inhibiting effect of the bisindole compound XQ-010 on CD133 + and CD44 + tumor stem cells, and has important clinical application value and development prospect.

The invention provides a chromone bisindole derivative as well as a preparation method and application thereof. According to the derivative, a chromone ketone ester compound with different substituted benzene rings is used as a raw material, the 3-site of the compound is structurally modified, and the compound and indole are subjected to an addition reaction to successfully synthesize 21 chromone bis-indole derivatives. The derivative contains chromone and indole dominant skeletons, has various biological activities, and especially has an outstanding anti-tumor effect. The method has the advantages of simple operation, short reaction time, high yield, easily available raw materials, good air stability and wide applicability, can provide a compound source for biological activity screening, and has important application value for drug screening and pharmaceutical industry.

The application discloses a kind of diindole derivatives and preparation method thereof, it is left-handed or right-handed optical active body or racemate with the following structural formula;Its preparation includes with isoindoline group propargyl alcohol compound and 2-indole methanol compound as raw material, with organic phosphoric acid catalyst as catalyst, reaction is obtained in organic solvent diindole derivative.The application utilizes catalytic tandem reaction method to synthesize diindole derivative, reaction condition is mild, process is simple, operation is convenient, the potential fluorescent property and biological activity of obtained product, this will have important significance to fluorescent material and synthesis drug screening.

This invention discloses an N-N axial chiral phase-transfer catalyst, its synthesis method, and its applications, belonging to the field of asymmetric catalytic synthesis technology. Using chiral 2,4-pentanediol and N-Boc-indolephenol as starting materials, this invention efficiently constructs an N-N axial chiral biscarbazole cyclic ether skeleton through a five-step reaction involving Mitsunobu etherification, deBoc protection, PIDA oxidative cyclization, radical bromoxymethylation, and intramolecular quaternization. This method eliminates the need for complex chiral resolution and noble metal coupling, employs mild reaction conditions, uses readily available and inexpensive starting materials, achieves high overall yield, and yields a product with an axial chirality ee value ≥98%. The resulting catalyst possesses excellent conformational rigidity, chiral induction ability, and phase-transfer performance, exhibiting broad substrate applicability. It also possesses bisindole ring bioactivity, making it widely applicable in asymmetric catalytic synthesis in pharmaceuticals, fine chemicals, and other fields, and providing new directions for the development of antibacterial and antitumor biomaterials.

The application discloses a preparation method of a 3,3'-bisindolylmethane compound. The method comprises the following steps: carrying out heteroarylation reaction of N-methyl indole compound and indole phosphonium salt in a solvent at 25-100 DEG C under the promotion of water; quenching the reaction; and extracting, washing, drying and concentrating the reaction product to obtain a crude product; and purifying the crude product to obtain the 3,3'-bisindolylmethane compound. The preparation method has the characteristics of mild reaction condition, good functional group tolerance, simple post-treatment, green step, low pollution and high economic benefit.

This invention relates to a thiophene-containing bisindolemethane-type α-glucosidase inhibitor, its preparation method, and its application, belonging to the field of glucosidase inhibitor preparation technology. Specifically, this invention discloses a thiophene-containing bisindolemethane-type α-glucosidase inhibitor, its preparation method, and its application. The method involves synthesizing a 3,3'-bisindolemethane compound through photo-oxidation and reduction of nitrohaloalkanes under blue light irradiation. Bromonitromethane participates in the reaction as a methylene precursor. The preparation process uses clean energy and yields a good yield of the 3,3'-bisindolemethane compound under mild conditions. Preliminary activity tests demonstrate that the bisindolemethane-type compound prepared by this invention has a significant inhibitory effect on α-glucosidase and can be used as a lead candidate for developing novel α-glucosidase inhibitors.