The invention relates to a synthesis method of an indole derivative shown by a nitrogenous
medicine intermediate (III). The method comprises the following steps of in a
solvent and in the insert gas
atmosphere, under the existence of catalysts, nitrogenous ligands and acid promoters, a compound shown by a formula (I) and a compound shown by a formula (II) take a reaction; after the reaction is completed,
post treatment is performed, so that a compound shown by the formula (III) is obtained. The formulas (I), (II) and (III) are shown as the accompanying drawing, wherein the R1 is selected from H or
halogen; the R2 is selected from H, C1-C6 alkyls, C1-C6 alkoxy or
halogen; or R2 and the substituted phenyl jointly form naphthyl. The method has the advantages that through the comprehensive selection and cooperation of the proper substrates, catalysts, nitrogenous ligands, acid promoters, solvents and the like, the range of the substrates is expanded; the
aryl-substituted indol compound can be obtained at a good yield, so that the good application prospects and study values are realized in the field of organic
chemical synthesis. The fire-new method is provided for the synthesis of the compounds of the kind.