Method for improving fertility of older animals
A technology for fecundity and animals, applied in the directions of pharmaceutical formulations, drug combinations, medical preparations containing active ingredients, etc., can solve the problem of low litter size, and achieve the goal of increasing litter size, increasing litter size, guaranteeing The effect of people's physical and mental health
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Embodiment 1
[0031] This example relates to a method for increasing the litter size of mice by oral administration of α-ketoglutaric acid, specifically adding α-ketoglutarate to the feed or drinking water of mice, and the mice take α-ketoglutarate The daily dose of diacid is 0.05g / kg. When the mice were 6 months old, naturally estrous female mice were selected and mated with the male mice in the same cage. The next morning, the plug was checked, and the female mice that saw the plug were picked out to calculate the mating rate during the estrus period and count the number of litters.
Embodiment 2~5
[0033] Compared with Example 1, the only difference is that in Examples 2-5, the daily doses of α-ketoglutaric acid are 0.00g / kg, 0.30g / kg, 0.78g / kg, 1.58g / kg respectively .
[0034] Records show that taking α-ketoglutaric acid at a daily dose of 0.05g / kg and 0.30g / kg can increase the mating rate and litter size of 6-month-old and 12-month-old mice. The daily dose of 0.78g / kg has no effect on 6-month-old mice, but it can increase the breeding rate and litter size of 12-month-old mice. A daily dose of 1.58g / kg can significantly increase the litter size of 6-month-old mice, but has no effect on 12-month-old mice.
experiment example 1
[0036] 1. Experimental animals
[0037] 277 Kunming white female mice aged about 8 weeks were used to carry out the above-mentioned embodiments 1-5. The Kunming white female mice were purchased from the Experimental Animal Center of the Chinese Academy of Military Medical Sciences, and the Kunming white female mice were randomly divided into 5 groups, 50 in each group. The female rats had free access to food (the experimental animal center of the Academy of Military Medical Sciences produced a full price nutrient pellet feed) and drinking water.
[0038] 2. The experimental conditions are: light 12h / d, indoor temperature 20-22°C.
[0039] 3. Experimental process
[0040]After a week of adaptive feeding of the experimental mother mice, α-ketoglutarate was added to the feed or drinking water, so that the daily dose of α-ketoglutarate for the mother mice was 0.05g / kg to 1.58g / kg, every day Change feed or water. When the mice were 6 months old and 12 months old, the female mice...
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