Method for improving fertility of older animals

A technology for fecundity and animals, applied in the directions of pharmaceutical formulations, drug combinations, medical preparations containing active ingredients, etc., can solve the problem of low litter size, and achieve the goal of increasing litter size, increasing litter size, guaranteeing The effect of people's physical and mental health

Active Publication Date: 2016-04-13
CHINA AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to environmental, nutritional, genetic, stress and other factors, the litter size of commercial pigs is relatively low

Method used

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  • Method for improving fertility of older animals
  • Method for improving fertility of older animals
  • Method for improving fertility of older animals

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] This example relates to a method for increasing the litter size of mice by oral administration of α-ketoglutaric acid, specifically adding α-ketoglutarate to the feed or drinking water of mice, and the mice take α-ketoglutarate The daily dose of diacid is 0.05g / kg. When the mice were 6 months old, naturally estrous female mice were selected and mated with the male mice in the same cage. The next morning, the plug was checked, and the female mice that saw the plug were picked out to calculate the mating rate during the estrus period and count the number of litters.

Embodiment 2～5

[0033] Compared with Example 1, the only difference is that in Examples 2-5, the daily doses of α-ketoglutaric acid are 0.00g / kg, 0.30g / kg, 0.78g / kg, 1.58g / kg respectively .

[0034] Records show that taking α-ketoglutaric acid at a daily dose of 0.05g / kg and 0.30g / kg can increase the mating rate and litter size of 6-month-old and 12-month-old mice. The daily dose of 0.78g / kg has no effect on 6-month-old mice, but it can increase the breeding rate and litter size of 12-month-old mice. A daily dose of 1.58g / kg can significantly increase the litter size of 6-month-old mice, but has no effect on 12-month-old mice.

experiment example 1

[0036] 1. Experimental animals

[0037] 277 Kunming white female mice aged about 8 weeks were used to carry out the above-mentioned embodiments 1-5. The Kunming white female mice were purchased from the Experimental Animal Center of the Chinese Academy of Military Medical Sciences, and the Kunming white female mice were randomly divided into 5 groups, 50 in each group. The female rats had free access to food (the experimental animal center of the Academy of Military Medical Sciences produced a full price nutrient pellet feed) and drinking water.

[0038] 2. The experimental conditions are: light 12h / d, indoor temperature 20-22°C.

[0039] 3. Experimental process

[0040]After a week of adaptive feeding of the experimental mother mice, α-ketoglutarate was added to the feed or drinking water, so that the daily dose of α-ketoglutarate for the mother mice was 0.05g / kg to 1.58g / kg, every day Change feed or water. When the mice were 6 months old and 12 months old, the female mice...

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Abstract

The invention relates to the field of animal husbandry and animal reproduction and particularly discloses a method for improving the fertility including the litter size and the sexual period breeding rate of older animals. It is found for the first time that the sexual period breeding rate and the litter size of multiparous animals can be remarkably increased by enabling the older animals to orally take a proper dose (the daily dose ranges from 0.05 g/kg to 1.58 g/kg) of alpha-ketoglutarate for a long time. The multiparous animals take alpha-ketoglutarate by adding alpha-ketoglutarate to drinking water or feed of the animals, adding according to requirements can be conveniently achieved, the dose can be changed in time, and the method can be widely used under an automatic feeding and water feeding system. The method is applied to livestock breeding, the edible safety of meat can be guaranteed, and meanwhile development of the breeding industry is also promoted.

Description

technical field [0001] The invention relates to the field of animal husbandry and animal reproduction, in particular to a method for improving the fecundity of older animals. Background technique [0002] Maximizing animal fecundity is one of the goals pursued by animal husbandry production, and it is also an important way to improve the economic benefits of animal husbandry. my country is a country with a large population, and there is a great demand for meat products. Among them, pork is the main meat consumed by Chinese residents. However, due to the influence of factors such as environment, nutrition, genetics, and stress, the litter size of commercial pigs is relatively low. At present, my country's annual slaughter of pigs is about 600 million, while the lowest number of sows is 41 million, with an average of 15 sows. One of the ideas to solve the problem is to increase the reproductive efficiency of animals, such as litter size. Therefore, it is extremely importan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02A61K31/194A61P15/08
CPCA01K67/02A61K31/194
Inventor 刘国世何长久张珍珍连正兴阿布力孜·吾斯曼朱宽峰马腾宋玉坤徐志远陶景丽
Owner CHINA AGRI UNIV
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