The invention belongs to the traditional Chinese medicine field, in particular relates to a drug for curing climacteric syndrome and a preparation method thereof. According to the etiology and pathogenesis of the traditional Chinese medical science, the drug which is kidney-tonifying-oriented adopts the traditional Chinese medicinal materials of radix rehmanniae recen, rhizoma anemarrhenae, dogwood, angelica, fried white peony root, caulis polygoni multiflori, lily, epimedium, radix achyranthis bidentatae, tuckahoe, dragon bone and raw oyster to be made into oral liquid, granules, tablets or capsules and has the functions for replenishing vital essence to tonify the kidney and nourishing blood and tranquilizing mind. The results of the pharmacodynamics experiment show that the level of E2 in the serum of ovariectomized rats is increased, the LH level is decreased obviously, and the uterus index and the water absorbed quantity percentage are increased. The results show that the drug of the invention overcomes the shortcomings of the estrogen, has evident curative effect on climacteric syndrome, can cure osteoporosis, is anti-aging and improves the immunologic function. The drug of the invention has good stability, high bioavailability and security and effectiveness if being taken for a long term.