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Medicament for treating climacteric syndrome and preparation method thereof

A technology for medicine and syndrome, which is applied to the compound preparation of traditional Chinese medicine for the treatment of climacteric syndrome and its preparation, and the field of medicine for the treatment of climacteric syndrome, can solve the problems of single treatment, inconvenience for patients to buy and take, etc. Hormone disadvantage, effect of significant curative effect

Inactive Publication Date: 2008-09-24
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these Chinese patent medicines are aimed at certain symptoms or a certain cause of menopausal syndrome, and the treatment is relatively simple, so it is not convenient for patients to purchase and take by themselves.

Method used

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  • Medicament for treating climacteric syndrome and preparation method thereof
  • Medicament for treating climacteric syndrome and preparation method thereof
  • Medicament for treating climacteric syndrome and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Chinese medicine compound preparation preparation and process selection of the present invention, wherein,

[0044] According to literature reports, after the crushed shellfish medicine is used as medicine, it does not need to be decocted first. After the raw keel and raw oysters in the above step 1 of the present invention are pulverized into coarse powder, they are passed through a 20-40 mesh sieve and directly used as medicine, which simplifies the process;

[0045] The selection of water extraction conditions in the above step 2: Rehmannia glutinosa, Anemarrhena, Cornus officinalis, Chinese angelica, fried white peony root, twig, lily, epimedium and Achyranthes bidentata, decocting and extracting. press L 9 (3 4 ) Orthogonal experiment, screened three factors that affect the extraction effect, the amount of water added, the number of decoctions and the decoction time, with three levels for each factor; the content of loganin, the content of icariin and the rate of ...

Embodiment 2

[0058] Embodiment 2 prepares oral liquid

[0059] Get medicinal material by following weight ratio:

[0060] Raw Rehmannia 7%, Anemarrhena 3%, Dogwood 6%, Angelica 6%

[0061] Stir-fried Paeoniae Alba 6%, Caulis 7%, Lily 6%, Epimedium 6%

[0062] Achyranthes bidentata 6% Poria cocos 9% Raw keel 19% Raw oyster 19%

[0063] Crush the raw keel and raw oysters into 20-40 mesh coarse powder and add 12 times the amount of water to other nine herbal medicines (except Poria cocos), soak for 1 hour and then extract, decoct for 60 minutes for the first time, add 8 times the amount of water for the second time , decoct for 60 minutes, combine the decoction, filter, concentrate the filtrate under reduced pressure, add ethanol under stirring, make the alcohol content reach 50%, leave it for 48 hours, filter, concentrate the filtrate until there is no alcohol smell, recover the ethanol, concentrate spare. After Poria cocos is crushed and soaked in warm water, add 5 times the amount of w...

Embodiment 3

[0064] Embodiment 3 prepares granule

[0065] Get medicinal material by following weight ratio:

[0066] Raw Rehmannia 10%, Anemarrhena 4%, Dogwood 8%, Angelica 8%

[0067] Stir-fried Paeoniae Alba 6%, Caulis 6% Lily 6%, Epimedium 6%

[0068] Achyranthes bidentata 8%, Poria cocos 8%, Raw keel 15%, Raw oyster 15%

[0069] Crush the raw keel and raw oysters into 20-40 mesh coarse powder and add 12 times the amount of water to other nine herbal medicines (except Poria cocos), soak for 1 hour and then extract, decoct for 60 minutes for the first time, add 8 times the amount of water for the second time , decocted for 60 minutes, combined the decoction, filtered, the filtrate was concentrated under reduced pressure, added ethanol under stirring, so that the alcohol content reached 50%, left for 48 hours, filtered, the filtrate was concentrated until there was no alcohol smell, recovered ethanol, and concentrated to obtain Extraction: take 50% of the extract and spray dry to obta...

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Abstract

The invention belongs to the traditional Chinese medicine field, in particular relates to a drug for curing climacteric syndrome and a preparation method thereof. According to the etiology and pathogenesis of the traditional Chinese medical science, the drug which is kidney-tonifying-oriented adopts the traditional Chinese medicinal materials of radix rehmanniae recen, rhizoma anemarrhenae, dogwood, angelica, fried white peony root, caulis polygoni multiflori, lily, epimedium, radix achyranthis bidentatae, tuckahoe, dragon bone and raw oyster to be made into oral liquid, granules, tablets or capsules and has the functions for replenishing vital essence to tonify the kidney and nourishing blood and tranquilizing mind. The results of the pharmacodynamics experiment show that the level of E2 in the serum of ovariectomized rats is increased, the LH level is decreased obviously, and the uterus index and the water absorbed quantity percentage are increased. The results show that the drug of the invention overcomes the shortcomings of the estrogen, has evident curative effect on climacteric syndrome, can cure osteoporosis, is anti-aging and improves the immunologic function. The drug of the invention has good stability, high bioavailability and security and effectiveness if being taken for a long term.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines and relates to medicines for treating menopausal syndrome. Specifically relates to a traditional Chinese medicine compound preparation for treating climacteric syndrome and a preparation method thereof. Background technique [0002] Menopausal syndrome (Menopausal Syndrome, MPS) refers to women before and after menopause due to the gradual decline of ovarian function and the decline of estrogen levels, a group of syndromes with autonomic nervous system dysfunction and neuropsychological symptoms, also known as perimenopause. period syndrome. [0003] Modern medical research shows that hypofunction of the ovaries and decreased estrogen levels are the main causes of menopausal syndrome. The imbalance of the hypothalamus-pituitary-ovary axis affects the functions of the autonomic nerve center and the organs under its control. Estrogen receptor (ER) is widely present in many tissues and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8967A61K9/08A61K9/10A61K9/16A61K9/20A61K9/48A61P15/12A61K35/02A61K35/56A61K35/618
Inventor 朱国福李秋爽
Owner SHANGHAI UNIV OF T C M
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