A quality detection method for traditional Chinese medicine prescriptions
A quality detection method and sample injection detection technology, which can be used in measuring devices, instruments, scientific instruments, etc., can solve the problems of inability to separate chromatographic peaks, unable to obtain satisfactory chromatographic peak resolution, etc., and achieve high-resolution quality analysis of traditional Chinese medicine, samples The processing process is simple and easy, and the effect of saving analysis time
Active Publication Date: 2018-03-27
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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[0003] However, for Compound Baidu Decoction, if the commonly used HPLC technology is used, it is found that the chromatographic peaks of the complex components in the compound cannot be separated at all. Satisfactory chromatographic peak resolution cannot be obtained, so it is necessary to find other suitable analytical methods to achieve the technical purpose of simultaneously determining the main medicinal components in Compound Baidu Decoction, and to achieve rapid, high-speed, and high-sensitivity determination And the technical effect of the determination method is simple and easy
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[0023] Embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings. It should be noted that, in the case of no conflict, the embodiments in the present application and the features in the embodiments can be combined arbitrarily with each other.
[0024] 1 Instruments and reagents
[0025] 1.1 Instrument Acquity UPLC (U.S. Waters Company, including binary high-pressure gradient pump, vacuum degasser, autosampler, column oven, DAD detector, Empower 2 chromatographic workstation); AL204 electronic microanalytical balance (Mettler- Toledo Instrument Co., Ltd.); ultrasonic cleaner (KQ-500DE, Kunshan Ultrasonic Instrument Co., Ltd.).
[0026] 1.2 Test drugs Compound Baidu Decoction (No. 302 Hospital of the Chinese People's Liberation Army), astilbin (batch number 111798-201102), forsythiaside A (batch number 111810-201103), forsythin (batch number 110821-201213), acetonitrile ( Chromatographically pure, Fisher Company), othe...
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The invention discloses a quality detection method of a traditional Chinese medicine prescription, and the existing name of the traditional Chinese medicine prescription is Compound Baidu Decoction. The method for detecting the quality of traditional Chinese medicine prescriptions in the present invention is to simultaneously measure the contents of astilbin, forsythiaside A and forsythin in Compound Baidu Decoction by using ultra-high-speed liquid chromatography (UPLC) at 275 nm. The method of the present invention adopts UPLC to measure each effective medicinal component of Compound Baidu Decoction, and has ultra-high separation, ultra-high speed, and ultra-high sensitivity for the components such as astilbin, forsythiaside A, and forsythin. and other advantages; better chromatographic peak resolution can be obtained in one sample injection, without complicated sample pretreatment process, greatly improving the chromatographic resolution and analysis speed, effectively saving analysis time, and realizing rapid and high-resolution compound extraction The quality analysis of Dutang traditional Chinese medicine has a good effect on clinical quality control.
Description
technical field [0001] The invention relates to a prescription of traditional Chinese medicine, in particular to a method for detecting and analyzing the quality of a prescription of traditional Chinese medicine. Background technique [0002] The traditional Chinese medicine prescription involved in the present invention is the agreement prescription of the 302nd Hospital of the People's Liberation Army. Rhodiola 5 ~ 20g composition, wherein Astragalus is the dry root of the perennial herb Astragalus mongolica or Astragalus membranaceus; Smilax is the dry rhizome of perennial climbing vine Smilax glabra in Liliaceae; The dried whole grass of the annual grassland ear grass; Forsythia is the dry fruit of the deciduous shrub Forsythia oleifera; Rhodiola is the dried rhizome of the perennial herb Rhodiola or Rhodiola latifolia in the family Sedum. The main medicinal ingredients are Forsythia, Smilax, etc., which have the effects of strengthening the spleen and kidney, soothing ...
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IPC IPC(8): G01N30/02
Inventor 张萍马艳芹房吉祥王伽伯李春雨王国强张蓉蓉董旖王江江乔潆
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL
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