Preparation method of radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation

A preparation method and preparation technology are applied in the field of preparation of Fugui Gutong preparations, which can solve the problems that the active ingredients of Codonopsis pilosula are difficult to detect, the polysaccharide content of Codonopsis pilosula is difficult to detect, and the clinical efficacy of Fugui Gutong preparations is not ideal, and the like. Significant effect, easy to measure, improve the effect of drug efficacy

Inactive Publication Date: 2016-05-04
GUIZHOU HUAANTANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the inventor found in the course of the research that the active ingredients of Codonopsis pilosula are not easy to detect in the Fuguigutong preparation prepared by the existing extraction process, especially the content of Codonopsis pilosula polysaccharides.
The clinical curative effect of Fuguigutong preparation is not ideal enough

Method used

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  • Preparation method of radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation
  • Preparation method of radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation
  • Preparation method of radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] Recipe: 266g Aconite, 133g Aconitum, 67g Cinnamon, 200g Codonopsis, 200g Angelica, 200g Fried Paeoniae Alba, 200g Epimedium, 133g Vinegar Frankincense and accessories.

[0074] Process: take Codonopsis pilosula, add 10 times the amount of water to soak for 20 minutes, decoct for 3 hours, filter, add 8 times the amount of water to extract the filter residue twice, 2 hours each time, filter, combine the filtrates, concentrate into a concentrated solution, and set aside; filter residue Then add 8 times the amount of 60% ethanol solution, reflux extraction 3 times, each time for 1h, filter, combine the filtrate, recover ethanol, and obtain the alcohol extract, combine the alcohol extract with the above water extract, and concentrate to 50-60°C The extract with a relative density of 1.10-1.20 is dried and crushed to obtain Codonopsis pilosula dry paste powder, which is set aside; take cinnamon and crush it into coarse particles, pass through a 20-mesh sieve, mix with 0.05 tim...

Embodiment 2

[0082] Recipe: 266g Aconite, 133g Aconitum, 67g Cinnamon, 200g Codonopsis, 200g Angelica, 200g Fried Paeoniae Alba, 200g Epimedium, 133g Vinegar Frankincense and accessories.

[0083] Process: take Codonopsis pilosula, add 10 times the amount of water to soak for 20 minutes, decoct for 3 hours, filter, add 8 times the amount of water to extract the filter residue twice, 2 hours each time, filter, combine the filtrates, concentrate into a concentrated solution, and set aside; filter residue Then add 8 times the amount of 60% ethanol solution, reflux extraction 3 times, each time for 1h, filter, combine the filtrate, recover ethanol, and obtain the alcohol extract, combine the alcohol extract with the above water extract, and concentrate to 50-60°C The extract with a relative density of 1.10-1.20 is dried and crushed to obtain Codonopsis pilosula dry paste powder, which is set aside; take cinnamon and crush it into coarse particles, pass through a 20-mesh sieve, mix with 0.05 tim...

Embodiment 3

[0091] Recipe: Recipe: 266g Radix Aconiti, 133g Radix Aconitum, 67g Cinnamon, 200g Codonopsis, 200g Angelica, 200g Fried Paeoniae Alba, 200g Epimedium, 133g Vinegar Frankincense and accessories.

[0092] Process: take Codonopsis pilosula, add 10 times the amount of water to soak for 20 minutes, decoct for 3 hours, filter, add 8 times the amount of water to extract the filter residue twice, 2 hours each time, filter, combine the filtrates, concentrate into a concentrated solution, and set aside; filter residue Then add 8 times the amount of 60% ethanol solution, reflux extraction 3 times, each time for 1h, filter, combine the filtrate, recover ethanol, and obtain the alcohol extract, combine the alcohol extract with the above water extract, and concentrate to 50-60°C The extract with a relative density of 1.10-1.20 is dried and crushed to obtain Codonopsis pilosula dry paste powder, which is set aside; take cinnamon and crush it into coarse particles, pass through a 20-mesh siev...

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Abstract

The invention discloses a preparation method of a radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation. The preparation is mainly prepared from radix aconiti lateralis praeparata, radix aconiti preparata, cortex cinnamomi, radix codonopsis, Chinese angelica, parched white peony root, herba epimedii and stir-baked frankincense with vinegar. According to the preparation method disclosed by the invention, a specific production process and parameters of the radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation are improved according to the properties and effects of all the components in the formula of the radix aconiti lateralis praeparata and cortex cinnamomi bone pain preparation, so that effective components in the radix codonopsis can be easily detected, especially, the content of the effective component of polysaccharide in the radix codonopsis is high. A drug is more refined, the drug effect is more remarkable, and the clinical effect is good.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a preparation method of Fugui Gutong preparation. Background technique [0002] Extraction of traditional Chinese medicine is a commonly used method in traditional Chinese medicine pharmacy. The chemical composition of traditional Chinese medicine is extremely complex, and it is necessary to extract the active ingredients of traditional Chinese medicine that are effective for the human body from the complex mixture. to improve efficacy. [0003] Fugui Gutong is mainly made from Radix Aconite, Rhizoma Aconitum, Cinnamon, Codonopsis, Angelica, Stir-fried Paeoniae Alba, Epimedium and Vinegar Frankincense; For diseases such as hypertrophic arthritis of the cervical spine and knee joints caused by yang deficiency and cold dampness. [0004] In the prior art, Fugui Gutong is made in the following way: Cinnamon is crushed into fine powder, prepared aconite, mad...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61P19/08A61P19/02
CPCA61K36/714A61K9/1623A61K9/1652A61K9/2059A61K36/232A61K36/296A61K36/324A61K36/344A61K36/54A61K36/65A61K36/71A61K2236/19A61K2236/331A61K2236/333A61K2236/39A61K2236/51
Inventor 韦卿游德仙吴鸿彭华曾海堃
Owner GUIZHOU HUAANTANG PHARMA CO LTD
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