Sustained-release meshed tablet capable of promoting bone growth and preparation method of sustained-release meshed tablet

Abstract

The invention discloses a sustained-release meshed tablet capable of promoting bone growth and a preparation method of the sustained-release meshed tablet. A carrier of the sustained-release meshed tablet is chitosan which is loaded with a bone growth factor BMP-2 and an anti-inflammation drug cephalosporin, and chitosan adopts a meshed structure; the drug material mainly comprises chitosan, the BMP-2 and the cephalosporin as components. The preparation method of the sustained-release meshed tablet comprises the following steps: chitosan with the meshed structure is prepared with glutaraldehyde as a crosslinking agent; prepared chitosan with the meshed structure is mixed with gelatin, then citric acid is added, a mixed solution is injected into a mold and air-dried, and a drug carrying meshed film is prepared; the bone growth factor BMP-2 and the anti-inflammation drug cephalosporin are sprayed to the drug carrying meshed film, and the sustained-release meshed tablet capable of promoting bone growth is obtained and used for wrapping a broken bone. The sustained-release meshed tablet capable of promoting bone growth not only can promote bone growth and diminish inflammation, but also can release a drug in a sustained manner, and the preparation process is simple.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to a sustained-release drug mesh for promoting bone growth and a preparation method thereof. Background technique [0002] Bone morphogenetic protein, referred to as BMP, is the only cell growth factor found so far that can induce osteogenesis alone, among which BMP-2 has the strongest osteogenic ability. BMP-2 can induce osteogenesis and cartilage formation in vitro and in vivo, and is a key protein that controls the different morphologies of mammalian bones during development. BMP-2, as a cytokine that induces osteogenic effect, has a significant dose-dependent effect on the induction of osteogenic effect. Small doses of BMP-2 have poor osteogenic induction effects, while high doses of BMP-2 have good osteogenic induction effects. But too fast bone formation will lead to low bone quality, and high doses of BMP-2 can also promote the osteoclast effect of osteoclasts and cause bo...