Method for extracting curcumin from turmeric

A curcumin, technology from turmeric, applied in the extraction of effective components of traditional Chinese medicine, in the field of extracting curcumin from turmeric, can solve the problems of waste and solvent consumption, and achieve the effect of convenient operation, simple equipment and high purity

Active Publication Date: 2016-06-15
BEIJING UNION UNIVERSITY
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Problems solved by technology

Thin-layer chromatography has a good separation effect, but it is only suitable for a small amount of samples; column chromatography has a lar

Method used

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  • Method for extracting curcumin from turmeric
  • Method for extracting curcumin from turmeric
  • Method for extracting curcumin from turmeric

Examples

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Embodiment 1

[0056] Solution preparation:

[0057] Preparation of 70-85% acetone: Accurately measure 700-850 mL of acetone, add distilled water to dilute to 1000 mL, and prepare 3000 mL for later use.

[0058] Preparation of acetonitrile-5% acetic acid (1:1): Accurately measure 500 mL of acetonitrile and 500 mL of 5% acetic acid, mix well, filter with a magnetic funnel, and store in an airtight state for later use.

[0059] Preparation of 5% acetic acid aqueous solution: Accurately measure 50 mL of acetic acid, dilute to 1000 mL with double-distilled water, mix well, filter with a magnetic funnel, and seal it for storage. Prepare 4000mL for use.

[0060] 1. Crude extraction of curcumin:

[0061] Accurately weigh 70.00 g of turmeric powder, 700 mL of 75% acetone, and sonicate for 15 min / time, with an interval of 20 min each. Extract 3 times, recover acetone under reduced pressure, and perform liquid-liquid extraction to obtain a brown oily extract, which is a crude curcumin extract, weig...

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Abstract

The invention provides a method for extracting curcumin from turmeric. The method comprises the following steps: weighing a certain amount of turmeric powder, adding 70-85% acetone according to the liquid-solid ratio of 1: 8-10, extracting for three times, decompressing and recovering acetone to obtain a dark brown oily extract, carrying out liquid-liquid extraction by the use of petroleum ether, water and ethyl acetate, carrying out crude separation, crystallizing and recrystallizing by the use of ethanol-water to obtain needle curcumin crystal, and measuring mass fraction by HPLC. Through calculation, purity detected by HPLC after crystallization can reach 88% and above, and purity detected by HPLC after recrystallization can reach 95% and above.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a method for extracting effective components of traditional Chinese medicine, in particular to a method for extracting curcumin from turmeric. Background technique [0002] Turmeric is the dry rhizome of the ginger plant Curcuma longa L., which has the functions of promoting qi and relieving pain, clearing the blood, dispelling wind and curing arthralgia. In recent years, pharmacological studies at home and abroad have found that turmeric has various effects such as prevention and treatment of cancer and brain neuroprotection, so it has attracted much attention. [1] . [0003] Curcumin, commonly known as curcumin, is mainly derived from the rhizome of turmeric, a plant belonging to the Zingiberaceae family. [2] . A large number of studies have proved that curcumin has various pharmacological effects such as antioxidant, anti-inflammatory, anti-cancer, scavenging free ...

Claims

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Application Information

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IPC IPC(8): C07C45/78C07C49/255
CPCC07C45/78C07C49/255
Inventor 黄汉昌
Owner BEIJING UNION UNIVERSITY
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