Application of chitosan metal complex particles as dosage carrier based on active oxygen responsiveness
A metal complex, chitosan technology, applied in pharmaceutical formulations, medical preparations of inactive ingredients, freeze-dried delivery, etc., can solve the problem of limiting the use of synthetic oxidation-responsive materials, strong immunoreactivity, and large retention in the body, etc. problem, to achieve the effect of improved oxidative response rate and in vitro release efficiency, and good histocompatibility
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[0035] Preparation of Chitosan Microparticles
[0036]Referring to Fan, W., etal., Formation mechanism of monodisperse, low molecular weight chitosannanoparticlesbyionicgelationtechnique[J].ColloidsandSurfacesB:Biointerfaces,2012.90(21):p.21-27. The method disclosed, according to the principle of ion gel method to prepare chitosan particles (CSNPs) The specific steps are: dissolving 50 mg of chitosan in 1% acetic acid solution to form a chitosan solution with a concentration of 2.5 mg / mL, and after magnetic stirring for 1 hour, adjust the pH to 5.3-5.5 with 1.0 mol / L sodium hydroxide solution, Stirring was continued for 0.5h. Then slowly add 8.0mL sodium polyphosphate solution (1.0mg / mL) into 20mL chitosan acetic acid solution dropwise at 500-600rpm, mix and react for 0.5h, centrifuge (3000rpm) for 10min and take the supernatant, CSNPs were obtained by freeze-drying.
[0037] Preparation of Chitosan Metal Complex Microparticles CSNPs-Met (Type A Carrier)
[0038] Preparatio...
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