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Application of chitosan metal complex particles as dosage carrier based on active oxygen responsiveness

A metal complex, chitosan technology, applied in pharmaceutical formulations, medical preparations of inactive ingredients, freeze-dried delivery, etc., can solve the problem of limiting the use of synthetic oxidation-responsive materials, strong immunoreactivity, and large retention in the body, etc. problem, to achieve the effect of improved oxidative response rate and in vitro release efficiency, and good histocompatibility

Inactive Publication Date: 2016-06-22
GUANGDONG PHARMA UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Although artificially synthesized oxidation-responsive materials have high reactivity with ROS, their preparation conditions and storage conditions are relatively high, they are highly toxic to cells, have a large amount of retention in the body, and have strong immune reactivity to the human body. To a certain extent, the use of synthetic oxidation-responsive materials in the field of medicine is limited
[0005] Existing studies mainly focus on the antibacterial and antitumor activities of chitosan metal complexes, but there is no report on the use of chitosan metal complex particles as oxidation-responsive drug carriers.

Method used

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  • Application of chitosan metal complex particles as dosage carrier based on active oxygen responsiveness
  • Application of chitosan metal complex particles as dosage carrier based on active oxygen responsiveness
  • Application of chitosan metal complex particles as dosage carrier based on active oxygen responsiveness

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Embodiment Construction

[0035] Preparation of Chitosan Microparticles

[0036]Referring to Fan, W., etal., Formation mechanism of monodisperse, low molecular weight chitosannanoparticlesbyionicgelationtechnique[J].ColloidsandSurfacesB:Biointerfaces,2012.90(21):p.21-27. The method disclosed, according to the principle of ion gel method to prepare chitosan particles (CSNPs) The specific steps are: dissolving 50 mg of chitosan in 1% acetic acid solution to form a chitosan solution with a concentration of 2.5 mg / mL, and after magnetic stirring for 1 hour, adjust the pH to 5.3-5.5 with 1.0 mol / L sodium hydroxide solution, Stirring was continued for 0.5h. Then slowly add 8.0mL sodium polyphosphate solution (1.0mg / mL) into 20mL chitosan acetic acid solution dropwise at 500-600rpm, mix and react for 0.5h, centrifuge (3000rpm) for 10min and take the supernatant, CSNPs were obtained by freeze-drying.

[0037] Preparation of Chitosan Metal Complex Microparticles CSNPs-Met (Type A Carrier)

[0038] Preparatio...

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Abstract

The invention discloses application of chitosan metal complex particles as a dosage carrier based on active oxygen responsiveness. The weight-average molecular weight of chitosan is 60-250 kDa, the degree of deacetylation is 80-95%, and the metal ions are divalent or trivalent metal ions. According to in-vitro ultraviolet turbidity measurement and nile red in-vitro release test results, it is found that the chitosan metal complex particles obtained through different methods have the good oxidation responsiveness, the oxidation response speeds and in-vitro release efficiency of two particles are remarkably increased on the existence condition of metal ions, and the chitosan metal complex particles are expected to be developed to be the novel drug carrier based on active oxygen intelligent responsiveness.

Description

technical field [0001] The invention relates to a new application of a material, in particular to the application of chitosan metal complex particles as a drug carrier based on active oxygen response. Background technique [0002] Oxidative stress can lead to changes in the content of reactive oxygen species (Reactive oxygen species, ROS) in the body. Oxidation-responsive materials can spontaneously change the macroscopic or microscopic properties of materials according to the changes in ROS content. Shrinkage, hardening, etc. This kind of material aimed at the change of oxidative microenvironment in the body is mainly used to enhance the targeting of drug carriers. At present, most of the researches are artificial synthetic materials through chemical modification, including organometallic polymers, organic conjugated polymers, containing Heteroatomic organic polymers. Although artificially synthesized oxidation-responsive materials have high reactivity with ROS, their pre...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/36A61K47/04A61K9/19
CPCA61K47/36A61K9/19A61K47/02
Inventor 陈钢温露夏立业张世倡
Owner GUANGDONG PHARMA UNIV
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