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A kind of coenzyme q10 aqueous dispersion and preparation method thereof

A dispersion and coenzyme technology, applied in the biological field, can solve problems such as unsafe factors, excessive dosage, and potential safety hazards, and achieve the effects of wide adaptability, good effect, and high safety

Inactive Publication Date: 2018-07-10
广西北部湾制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Preparation of coenzyme Q10 into water dispersion is a method to improve bioavailability. Domestic patents use physiologically active antioxidants to protect coenzyme Q10, which has certain potential safety hazards
Foreign patents are mainly Japanese patents. W02006134970 uses a large amount of sucrose fatty acid ester as an emulsifier, which is costly and excessively used, which has potential and unknown unsafe factors

Method used

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  • A kind of coenzyme q10 aqueous dispersion and preparation method thereof
  • A kind of coenzyme q10 aqueous dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] An aqueous dispersion of coenzyme Q10 and a preparation method thereof, specifically comprising the following steps:

[0033] 1) Preparation of raw materials: Prepare coenzyme Q10, gum arabic, lactose, emulsifier, soluble starch, co-solvent, and water according to the weight ratio of 1:0.20:0.04:0.004:0.06:0.02;

[0034] 2) Dissolve gum arabic in water, then add soluble starch, lactose, and Tween, heat to 55°C to dissolve, stir evenly, and set aside;

[0035] 3) Heat polyethylene glycol to dissolve, then add coenzyme Q10, heat to 55°C to dissolve, and set aside;

[0036] 4) Pressure treatment: put the materials processed in step 2) and step 3) into a high-pressure tank, and pressurize to 4kg / cm 2 , to make the pressure uniform, and keep it for 5-10min, and then return to normal pressure within 1-3s to obtain a mixed solution;

[0037] 5) Spray-dry the mixed solution obtained in step 4) to obtain coenzyme Q10 aqueous dispersion powder;

[0038] The coenzyme Q10 descri...

Embodiment 2

[0045] An aqueous dispersion of coenzyme Q10 and a preparation method thereof, specifically comprising the following steps:

[0046] 1) Preparation of raw materials: Prepare coenzyme Q10, gelatin, D-galactose, emulsifier, soluble starch, co-solvent, and water according to the weight ratio of 1:0.30:0.02:0.006:0.04:0.04;

[0047] 2) Dissolve the gelatin with water, then add soluble starch, D-galactose, and Tween, heat to 60°C to dissolve, stir evenly, and set aside;

[0048] 3) Heat polyethylene glycol to dissolve, then add coenzyme Q10, heat to 60°C to dissolve, and set aside;

[0049] 4) Pressure treatment: put the materials processed in step 2) and step 3) into a high-pressure tank, and pressurize to 4kg / cm 2 , to make the pressure uniform, and keep it for 5-10min, and then return to normal pressure within 1-3s to obtain a mixed solution;

[0050] 5) Spray-dry the mixed solution obtained in step 4) to obtain coenzyme Q10 aqueous dispersion powder;

[0051] The coenzyme Q1...

Embodiment 3

[0058] An aqueous dispersion of coenzyme Q10 and a preparation method thereof, specifically comprising the following steps:

[0059] 1) Preparation of raw materials: Prepare coenzyme Q10, gum arabic, lactose, emulsifier, soluble starch, co-solvent, and water according to the weight ratio of 1:0.25:0.03:0.005:0.05:0.03;

[0060] 2) Dissolve gum arabic in water, then add soluble starch, lactose, sucrose ester, heat to 55°C to dissolve, stir evenly, and set aside;

[0061] 3) Heat the poloxamer to dissolve, then add coenzyme Q10, heat to 60°C to dissolve, and set aside;

[0062] 4) Pressure treatment: put the materials processed in step 2) and step 3) into a high-pressure tank, and pressurize to 4kg / cm 2 , to make the pressure uniform, and keep it for 5-10min, and then return to normal pressure within 1-3s to obtain a mixed solution;

[0063] 5) Spray-dry the mixed solution obtained in step 4) to obtain coenzyme Q10 aqueous dispersion powder;

[0064] The coenzyme Q10 describe...

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Abstract

The invention discloses a coenzyme Q10 aqueous dispersion and a preparing method thereof. The preparing method comprises the following steps that 1, raw materials are prepared, wherein coenzyme Q10, gum substance, sugar, an emulsifying agent, soluble starch, cosolvent and water are prepared; 2, water is added into the gum substance to dissolve the gum substance, the soluble starch, the sugar and the emulsifying agent are added, and the mixture is heated, dissolved and stirred uniformly for use; 3, the cosolvent is heated and dissolved, and then coenzyme Q10 is added, heated and dissolved for use; 4, pressurizing is carried out, materials treated in the step two and the step three are placed into a high-pressure tank and pressurized to 4 kg / cm<2> to enable pressure to be uniform, the pressure is kept for 5-10 min, and then normal pressure is restored within 1-3 seconds, so that mixed liquor is obtained; 5, the mixed liquor obtained in the step four is dried in a spraying mode, so that coenzyme Q10 aqueous dispersion powder is obtained.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an aqueous dispersion of coenzyme Q10 and a preparation method thereof. Background technique [0002] Coenzyme Q10, English name: COENZYME Q10, CAS No.303-98-0, molecular formula C 59 h 90 o 4 , molecular weight 863.36, yellow to orange crystalline powder, odorless and tasteless, easy to decompose when exposed to light, slightly soluble in ethanol, insoluble in water. Ubiquinone 10, also known as ubiquinone 10, is a fat-soluble quinone whose structure is similar to vitamin K. quinone ring compounds. Coenzyme Q10 is one of the indispensable and important elements of human life. It can activate the nutrition of human cells and cell energy. It has the functions of improving human immunity, enhancing anti-oxidation, delaying aging and enhancing human vitality. It is widely used in the cardiovascular system in medicine. diseases, it is widely used in nutritional health products and f...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K8/35A61Q19/08A61Q19/00
CPCA23V2002/00A61K8/355A61Q19/00A61Q19/08A23V2250/314
Inventor 劳雪红
Owner 广西北部湾制药股份有限公司
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