The invention discloses a coenzyme Q10 aqueous dispersion and a preparing method thereof. The preparing method comprises the following steps that 1, raw materials are prepared, wherein coenzyme Q10, gum substance, sugar, an emulsifying agent, soluble starch, cosolvent and water are prepared; 2, water is added into the gum substance to dissolve the gum substance, the soluble starch, the sugar and the emulsifying agent are added, and the mixture is heated, dissolved and stirred uniformly for use; 3, the cosolvent is heated and dissolved, and then coenzyme Q10 is added, heated and dissolved for use; 4, pressurizing is carried out, materials treated in the step two and the step three are placed into a high-pressure tank and pressurized to 4 kg / cm<2> to enable pressure to be uniform, the pressure is kept for 5-10 min, and then normal pressure is restored within 1-3 seconds, so that mixed liquor is obtained; 5, the mixed liquor obtained in the step four is dried in a spraying mode, so that coenzyme Q10 aqueous dispersion powder is obtained.