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Coenzyme Q10 aqueous dispersion and preparation process thereof

A preparation process and dispersion technology, which is applied in the field of coenzyme Q10 water dispersion and its preparation process, can solve problems such as unsafe factors, excessive dosage, and potential safety hazards, and achieve a wide adaptability, good effect, and high safety. Effect

Inactive Publication Date: 2016-07-20
广西北部湾制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Preparation of coenzyme Q10 into water dispersion is a method to improve bioavailability. Domestic patents use physiologically active antioxidants to protect coenzyme Q10, which has certain potential safety hazards
Foreign patents are mainly Japanese patents. W02006134970 uses a large amount of sucrose fatty acid ester as an emulsifier, which is costly and excessively used, which has potential and unknown unsafe factors

Method used

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  • Coenzyme Q10 aqueous dispersion and preparation process thereof
  • Coenzyme Q10 aqueous dispersion and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] An aqueous dispersion of coenzyme Q10 and a preparation process thereof, specifically comprising the steps of:

[0033] 1) Preparation of raw materials: Prepare coenzyme Q10, gum arabic, lactose, emulsifier, soluble starch, co-solvent, and water according to the weight ratio of 1:0.20:0.04:0.004:0.06:0.02;

[0034] 2) Dissolve gum arabic in water, then add soluble starch, lactose, and Tween, heat to 55°C to dissolve, stir evenly, and set aside;

[0035] 3) Heat polyethylene glycol to dissolve, then add coenzyme Q10, heat to 55°C to dissolve, and set aside;

[0036] 4) Pressure treatment: put the materials processed in step 2) and step 3) into a high-pressure tank, and pressurize to 4kg / cm 2 , to make the pressure uniform, and keep it for 5-10min, and then return to normal pressure within 1-3s to obtain a mixed solution;

[0037] 5) Spray-dry the mixed solution obtained in step 4) to obtain coenzyme Q10 aqueous dispersion powder;

[0038] The coenzyme Q10 described in...

Embodiment 2

[0045] An aqueous dispersion of coenzyme Q10 and a preparation process thereof, specifically comprising the steps of:

[0046] 1) Preparation of raw materials: Prepare coenzyme Q10, gelatin, D-galactose, emulsifier, soluble starch, co-solvent, and water according to the weight ratio of 1:0.30:0.02:0.006:0.04:0.04;

[0047] 2) Dissolve the gelatin with water, then add soluble starch, D-galactose, and Tween, heat to 60°C to dissolve, stir evenly, and set aside;

[0048] 3) Heat polyethylene glycol to dissolve, then add coenzyme Q10, heat to 60°C to dissolve, and set aside;

[0049] 4) Pressure treatment: put the materials processed in step 2) and step 3) into a high-pressure tank, and pressurize to 4kg / cm 2 , to make the pressure uniform, and keep it for 5-10min, and then return to normal pressure within 1-3s to obtain a mixed solution;

[0050] 5) Spray-dry the mixed solution obtained in step 4) to obtain coenzyme Q10 aqueous dispersion powder;

[0051] The coenzyme Q10 desc...

Embodiment 3

[0058] An aqueous dispersion of coenzyme Q10 and a preparation process thereof, specifically comprising the steps of:

[0059] 1) Preparation of raw materials: Prepare coenzyme Q10, gum arabic, lactose, emulsifier, soluble starch, co-solvent, and water according to the weight ratio of 1:0.25:0.03:0.005:0.05:0.03;

[0060] 2) Dissolve gum arabic in water, then add soluble starch, lactose, sucrose ester, heat to 55°C to dissolve, stir evenly, and set aside;

[0061] 3) Heat the poloxamer to dissolve, then add coenzyme Q10, heat to 60°C to dissolve, and set aside;

[0062] 4) Pressure treatment: put the materials processed in step 2) and step 3) into a high-pressure tank, and pressurize to 4kg / cm 2 , to make the pressure uniform, and keep it for 5-10min, and then return to normal pressure within 1-3s to obtain a mixed solution;

[0063] 5) Spray-dry the mixed solution obtained in step 4) to obtain coenzyme Q10 aqueous dispersion powder;

[0064] The coenzyme Q10 described in s...

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Abstract

The invention discloses a coenzyme Q10 aqueous dispersion and a preparation process thereof.The preparation process includes the following steps that firstly, raw material preparation is carried out, wherein coenzyme Q10, gum matter, sugar, an emulsifier, soluble starch, a cosolvent and water are prepared; secondly, the gum matter is added into water to be dissolved, then the soluble starch, the sugar and the emulsifier are added and heated to be dissolved, and the solution is stirred evenly for use; thirdly, the cosolvent is heated to be dissolved, and then the coenzyme Q10 is added and heated to be dissolved for use; fourthly, pressurizing treatment is carried out, wherein the materials treated in the second step and the third step are put into a high-pressure tank and pressurized to 4 kg / cm<2>, the pressure is made uniform, kept for 5-10 min and then restored to be normal within 1-3 s, and mixed liquor is obtained; fifthly, the mixed liquor obtained in the fourth step is subjected to spray drying, and coenzyme Q10 aqueous dispersion powder is obtained.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to an aqueous dispersion of coenzyme Q10 and a preparation process thereof. Background technique [0002] Coenzyme Q10, English name: COENZYMEQ10, CASNo.303-98-0, molecular formula C 59 h 90 o 4 , molecular weight 863.36, yellow to orange crystalline powder, odorless and tasteless, easy to decompose when exposed to light, slightly soluble in ethanol, insoluble in water. Ubiquinone 10, also known as ubiquinone 10, is a fat-soluble quinone whose structure is similar to vitamin K. quinone ring compounds. Coenzyme Q10 is one of the indispensable and important elements of human life. It can activate the nutrition of human cells and cell energy. It has the functions of improving human immunity, enhancing anti-oxidation, delaying aging and enhancing human vitality. It is widely used in the cardiovascular system in medicine. diseases, it is widely used in nutritional health products and fo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/122A61K8/35A61P9/00A61P9/10A61P37/04A61P39/06A61P19/08A23L33/10A23L5/30
CPCA23V2002/00A61K8/355A61K9/146A61K31/122A23V2200/30A23V2200/324A23V2200/302A23V2250/5028A23V2250/5432A23V2250/612A23V2250/608
Inventor 劳雪红
Owner 广西北部湾制药股份有限公司
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