Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Aqueous dispersion of coenzyme q10 and preparation method thereof

A dispersion and coenzyme technology, applied in the biological field, can solve problems such as unsafe factors, excessive dosage, and potential safety hazards, and achieve the effects of wide adaptability, good effect, and high safety

Inactive Publication Date: 2018-07-03
广西北部湾制药股份有限公司
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Preparation of coenzyme Q10 into water dispersion is a method to improve bioavailability. Domestic patents use physiologically active antioxidants to protect coenzyme Q10, which has certain potential safety hazards
Foreign patents are mainly Japanese patents. WO2006134970 uses a large amount of sucrose fatty acid ester as an emulsifier, which is costly and excessive, and has potential and unknown unsafe factors

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Aqueous dispersion of coenzyme q10 and preparation method thereof
  • Aqueous dispersion of coenzyme q10 and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Coenzyme Q10 aqueous dispersion and preparation method thereof, specifically comprising the following steps:

[0033] 1) Preparation of raw materials: Prepare coenzyme Q10, gum arabic, lactose, emulsifier, soluble starch, co-solvent, and water according to the weight ratio of 1:0.20:0.04:0.004:0.06:0.02;

[0034] 2) Dissolve gum arabic in water, then add soluble starch, lactose, and Tween, heat to 55°C to dissolve, stir evenly, and set aside;

[0035] 3) Heat polyethylene glycol to dissolve, then add coenzyme Q10, heat to 55°C to dissolve, and set aside;

[0036] 4) Pressure treatment: put the materials processed in step 2) and step 3) into a high-pressure tank, and pressurize to 4kg / cm 2 , to make the pressure uniform, and keep it for 5-10min, and then return to normal pressure within 1-3s to obtain a mixed solution;

[0037] 5) Spray-dry the mixed solution obtained in step 4) to obtain coenzyme Q10 aqueous dispersion powder;

[0038] The coenzyme Q10 described in s...

Embodiment 2

[0045] Coenzyme Q10 aqueous dispersion and preparation method thereof, specifically comprising the following steps:

[0046] 1) Preparation of raw materials: Prepare coenzyme Q10, gelatin, D-galactose, emulsifier, soluble starch, co-solvent, and water according to the weight ratio of 1:0.30:0.02:0.006:0.04:0.04;

[0047] 2) Dissolve the gelatin with water, then add soluble starch, D-galactose, and Tween, heat to 60°C to dissolve, stir evenly, and set aside;

[0048] 3) Heat polyethylene glycol to dissolve, then add coenzyme Q10, heat to 60°C to dissolve, and set aside;

[0049] 4) Pressure treatment: put the materials processed in step 2) and step 3) into a high-pressure tank, and pressurize to 4kg / cm 2 , to make the pressure uniform, and keep it for 5-10min, and then return to normal pressure within 1-3s to obtain a mixed solution;

[0050] 5) Spray-dry the mixed solution obtained in step 4) to obtain coenzyme Q10 aqueous dispersion powder;

[0051] The coenzyme Q10 descri...

Embodiment 3

[0058] Coenzyme Q10 aqueous dispersion and preparation method thereof, specifically comprising the following steps:

[0059] 1) Preparation of raw materials: Prepare coenzyme Q10, gum arabic, lactose, emulsifier, soluble starch, co-solvent, and water according to the weight ratio of 1:0.25:0.03:0.005:0.05:0.03;

[0060] 2) Dissolve gum arabic in water, then add soluble starch, lactose, sucrose ester, heat to 55°C to dissolve, stir evenly, and set aside;

[0061] 3) Heat the poloxamer to dissolve, then add coenzyme Q10, heat to 60°C to dissolve, and set aside;

[0062] 4) Pressure treatment: put the materials processed in step 2) and step 3) into a high-pressure tank, and pressurize to 4kg / cm 2 , to make the pressure uniform, and keep it for 5-10min, and then return to normal pressure within 1-3s to obtain a mixed solution;

[0063] 5) Spray-dry the mixed solution obtained in step 4) to obtain coenzyme Q10 aqueous dispersion powder;

[0064] The coenzyme Q10 described in ste...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses coenzyme Q10 aqueous dispersion and a preparation method thereof. The preparation method comprises the following steps: 1) preparing raw materials, namely, preparing coenzyme Q10, gum substances, sugar, an emulsifier, soluble starch, a cosolvent and water; 2) adding water to dissolve the gum substances, further adding the soluble starch, the sugar and the emulsifier, heating to dissolve the materials, and uniformly stirring for later use; 3) heating to dissolve the cosolvent, further adding coenzyme Q10, and heating to dissolve the materials for later use; 4) performing pressurization treatment, namely, putting materials treated in the step 2) and the step 3) into a high-pressure tank, pressurizing to 4kg / cm<2>, balancing the pressure, keeping the pressure for 5-10 minutes, recovering the normal pressure within 1-3s seconds, thereby obtaining a mixed liquid; and 5) performing spray drying on the mixed liquid in the step 4), thereby obtaining coenzyme Q10 aqueous dispersion powder.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a coenzyme Q10 aqueous dispersion and a preparation method thereof. Background technique [0002] Coenzyme Q10, English name: COENZYME Q10, CAS No.303-98-0, molecular formula C 59 h 90 o 4 , molecular weight 863.36, yellow to orange crystalline powder, odorless and tasteless, easy to decompose when exposed to light, slightly soluble in ethanol, insoluble in water. Ubiquinone 10, also known as ubiquinone 10, is a fat-soluble quinone whose structure is similar to vitamin K. quinone ring compounds. Coenzyme Q10 is one of the indispensable and important elements of human life. It can activate the nutrition of human cells and cell energy. It has the functions of improving human immunity, enhancing anti-oxidation, delaying aging and enhancing human vitality. It is widely used in the cardiovascular system in medicine. diseases, it is widely used in nutritional health products and food ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A23L33/00A23L5/30A61K31/122A61P9/00A61P37/04A61P39/06A61K8/35A61Q19/08
CPCA23V2002/00A61K8/355A61K9/146A61K31/122A61Q19/08A23V2200/222A23V2200/238A23V2200/324A23V2200/302A23V2250/314A23V2250/60A23V2250/502A23V2250/5118
Inventor 劳雪红
Owner 广西北部湾制药股份有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com