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Baicalin magnesium compound and preparation method and application thereof

A technology of magnesium compound and magnesium baicalin, applied in the field of medicine, can solve the problems of poor water solubility of baicalin, reduced efficacy of baicalin, low bioavailability, etc., and achieves improved oral bioavailability, improved solubility, and increased drug effective effect

Active Publication Date: 2016-07-06
CHENGDE MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The original form of baicalin in Scutellaria baicalensis is in the form of magnesium salt. This form has good water solubility and can be extracted by dissolving in water, but the acid precipitation destroys its original structure, making the water solubility of baicalin worse and absorption Slow speed, low bioavailability, and reduced efficacy of baicalin

Method used

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  • Baicalin magnesium compound and preparation method and application thereof
  • Baicalin magnesium compound and preparation method and application thereof
  • Baicalin magnesium compound and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0166] Embodiment 1: preparation baicalin magnesium compound

[0167] The implementation steps of this embodiment are as follows:

[0168] A, preparation of baicalin suspension

[0169] According to the ratio of baicalin in grams to purified water in milliliters as 1:30, add baicalin powder to purified water and mix well to obtain a baicalin suspension;

[0170] B, prepare the baicalin suspension containing magnesium ion

[0171] According to the molar ratio of baicalin and magnesium of 1.0:1.0, magnesium hydroxide and magnesium compounds are added to the baicalin suspension obtained in step A, and mixed uniformly to obtain a baicalin suspension containing magnesium ions;

[0172] C. Response

[0173] Under the condition of stirring, let the magnesium ion-containing baicalin suspension obtained in step B react at a temperature of 30° C. until the reaction system becomes clear and transparent, and filter it using a Buchner funnel vacuum filtration device to obtain a filtrate...

Embodiment 2

[0176] Embodiment 2: preparation baicalin magnesium compound

[0177] The implementation steps of this embodiment are as follows:

[0178] A, preparation of baicalin suspension

[0179] According to the ratio of baicalin in grams to purified water in milliliters as 1:50, add baicalin powder to purified water and mix well to obtain a baicalin suspension;

[0180] B, prepare the baicalin suspension containing magnesium ion

[0181] According to the molar ratio of baicalin and magnesium of 2.0:1.0, magnesium oxide magnesium compound is added to the baicalin suspension obtained in step A, and mixed uniformly to obtain a baicalin suspension containing magnesium ions;

[0182] C. Response

[0183] Under the condition of stirring, let the magnesium ion-containing baicalin suspension obtained in step B react at a temperature of 70° C. until the reaction system becomes clear and transparent, and filter it using a Buchner funnel decompression suction filtration device to obtain the f...

Embodiment 3

[0186] Embodiment 3: preparation baicalin magnesium compound

[0187] The implementation steps of this embodiment are as follows:

[0188] A, preparation of baicalin suspension

[0189] According to the ratio of baicalin in grams to purified water in milliliters as 1:20, add baicalin powder to purified water and mix well to obtain a baicalin suspension;

[0190] B, prepare the baicalin suspension containing magnesium ion

[0191] According to the molar ratio of baicalin and magnesium of 0.5:1.0, a basic magnesium carbonate magnesium compound is added to the baicalin suspension obtained in step A, and mixed uniformly to obtain a baicalin suspension containing magnesium ions;

[0192] C. Response

[0193] Under the condition of stirring, let the magnesium ion-containing baicalin suspension obtained in step B react at a temperature of 60° C. until the reaction system becomes clear and transparent, and filter it using a Buchner funnel vacuum suction filtration device to obtain ...

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Abstract

The invention relates to a baicalin magnesium compound and further relates to a preparation method and extracting method of the baicalin magnesium compound.The preparation method comprises the steps of baicalin suspension preparation, magnesium ion mixed suspension preparation, reaction, drying and the like.The extracting method comprises macroreticular resin preprocessing, extracting, adsorbing and eluting, concentrating and drying, purifying and the like.The prepared baicalin magnesium restores the existing way of baicalin in scutellaria baicalensis and can replace scutellaria baicalensis to be used as medicine.Compared with the baicalin, the baicalin magnesium compound has the advantages that the solubility is greatly improved, the oral absorption speed is higher, the bioavailability is higher, and the baicalin magnesium compound can very conveniently prepared into water-soluble injection or powder injection.Pharmacological experiments indicate that the pharmacological activity of baicalin magnesium is superior to that of baicalin.

Description

【Technical field】 [0001] The invention belongs to the technical field of medicine. More specifically, the present invention relates to a magnesium baicalin compound, a method for extracting and preparing the magnesium baicalin compound, and an application of the magnesium baicalin compound. 【Background technique】 [0002] Scutellaria baicalensis was first recorded in "Shen Nong's Materia Medica", and it is the dried root of Scutellaria baicalensis Georgi, a plant of the Labiatae family. Baicalin is a flavonoid compound contained in Scutellaria baicalensis with the molecular formula C 21 h 18 o 11 , the content in Scutellaria baicalensis is more than 9% by weight, even as high as 20% by weight, and is one of the main active ingredients of Scutellaria baicalensis. [0003] Modern pharmacological studies have shown that baicalin has the functions of scavenging oxygen free radicals, antiarrhythmia, expanding cardiovascular and cerebrovascular, lowering blood pressure and sed...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H23/00C07H1/00A61K31/7048A61P1/16A61P9/10A61P3/10A61P29/00A61P35/00
CPCC07H1/00C07H23/00A61K31/7048C07H1/08C07H17/07A61P3/10A61P29/02A61P35/00
Inventor 刘翠哲王志轩苗策禹刘丽艳刘沛薛禾菲刘喜纲杜闻杉刘一鑫张琳毛晓霞刘进军赵桂琴
Owner CHENGDE MEDICAL UNIV
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