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Taxol-10-deacetylbaccatine III bi-molecular metal-coordination imprinted material and preparation method and application thereof

A deacetylated bacca, metal coordination technology, applied in other chemical processes, chemical instruments and methods, etc., can solve the problems of difficult simultaneous extraction of two compounds, time-consuming and labor-intensive, etc.

Active Publication Date: 2016-07-06
田鑫
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are many methods for extracting paclitaxel and 10-deacetylbaccatin III, but the traditional extraction method is not only time-consuming and laborious, but also difficult to achieve simultaneous extraction of the two compounds

Method used

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Embodiment Construction

[0014] The paclitaxel-10-deacetylbaccatin III bimolecular metal coordination imprinted material, its preparation method and application will be described in detail below.

[0015] Accurately weigh 0.1mmol template molecule, dissolve 0.1mmol nickel acetate in 4.0mL acetonitrile-dimethyl sulfoxide (3 / 1, v / v) mixed solution and shake for 10min, add mixed functional monomers 4-VP and 2-VP 0.4mmol each, shake for 30min to make it fully react with the functional monomer, then add 3.0mmol cross-linking agent EDMA and 30.0mg initiator AIBN, mix well, transfer to a round bottom flask, ultrasonically degas for 15min, and pass in argon Gas for 15 minutes, seal the bottle; put the round bottom flask into a 60°C constant temperature water bath for 24 hours of polymerization reaction; crush the obtained blocky polymer, pass through a 200-mesh sieve, settle with acetone for 3 times, each time for 30 minutes, and discard the upper layer The turbid liquid is used to remove the superfine partic...

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PUM

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Abstract

The invention discloses a taxol-10-deacetylbaccatine III bi-molecular metal-coordination imprinted material and a preparation method and application thereof.With a Co2+ -taxol-10- deacetylbaccatine III coordination compound being a template molecule, the amount-of-substance ratio of taxol-10-deacetylbaccatine III is controlled, the usage amount ratio of metal ions, ligand, functional monomers and a cross-linking agent in a pre-reaction mixed liquor is adjusted, and therefore bi-template-molecule imprinted polymer is successfully prepared.The obtained imprinted polymer has rapid adsorption kinetics for taxol and 10-deacetylbaccatine III; with the molecule imprinted polymer being an adsorption medium, the two compounds of taxol and 10-deacetylbaccatine III can be separated well from taxus chinensis rough extract through solid-phase extraction, and the total recovery rates are 90.38% and 93.60% respectively.The new material and the new application method are provided for gathering and separating of a natural product and trace active compounds in Chinese herbs.

Description

technical field [0001] The invention relates to a paclitaxel-10-deacetylbaccatin III bimolecular metal coordination imprinting material and its preparation method and application. Background technique [0002] Molecularly imprinted polymer is a new type of polymer material with high specificity for specific target molecules prepared by molecular imprinting technology. It has the three characteristics of predetermined structure and activity, specific recognition and wide practicability, so it has been highly developed in recent decades. At the same time, because it is artificially synthesized by chemical methods, it has the advantages that natural molecular recognition systems do not have, such as strong acid and alkali resistance, corrosion resistance, resistance to harsh environments, easy storage, high reuse rate, and low price. It is widely used in many fields such as environment, food, biology and medical engineering. [0003] Yew, also known as yew, is known as "plant...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F226/06C08F222/14C08J9/26B01J20/26B01J20/30
CPCB01J20/268B01J2220/445B01J2220/4806B01J2220/4812C08F226/06C08J9/26C08J2339/04C08F222/14
Inventor 李辉张月王素素龚梦婷
Owner 田鑫
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