Specific protein composition and application method thereof

Abstract

The invention provides a specific protein composition and an application method thereof targeted to passive immunity and clostridium tetani infection prevention of a patient who is bitten or scratched by a mad dog or other mad animals.The specific protein composition and the application method thereof are mainly characterized in that the specific protein composition is formed by mixing human rabies immune globulin and human tetanus immune globulin, wherein the valence of antibodies of the human rabies immune globulin is not lower than 20 IU / ml, the valence of antibodies of the human tetanus immune globulin is not lower than 8 IU / ml, and the value ratio of the valence of antibodies of the human rabies immune globulin to the valence of antibodies of the human tetanus immune globulin is 2.5: 1.The application method comprises the steps of conducting thorough debridement in time; firstly, taking a half of the specific protein composition for conducting subcutaneous infiltration injection on the periphery of the injured part of the patient, and conducting intramuscular injection with the remaining half.The specific protein composition is mainly used for preventing the patient who is bitten or scratched by a mad dog or other mad animals from suffering from rabies and tetanus; the injection amount of the human rabies immune globulin is 10-40 IU / kg, and the injection amount of the human tetanus immune globulin is 4-40 IU / kg.

Description

technical field [0001] The invention relates to a medicine, in particular to a medicine for passive immunization and prevention of tetanus bacillus infection for patients bitten or scratched by rabies or other mad animals and its application method. Background technique [0002] 1. Human Rabies Immunoglobulin [0003] Inoculation of human rabies immunoglobulin and rabies vaccine is an important measure to prevent the onset of severe dog bites. Rabies, commonly known as "mad dog disease", is a zoonotic central nervous system infectious disease caused by rabies virus. The clinical manifestation is hydrophobia. , photophobia, dysphagia, mania, etc. as the main features, is so far the only acute infectious disease in humans with a fatality rate as high as 100%. The "Law of the People's Republic of China on the Prevention and Control of Infectious Diseases" lists rabies as a Class B infectious disease. [0004] This strain is made from the plasma of healthy people immunized wit...

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Problems solved by technology

[0012] The above two specific immunoglobulins have the following defects in clinical use: one is that the two specific immunoglobulins need to be injected separately, and the injection sites are different, which makes the operation more troublesome; the other is that the prophylactic injection of human tetanus immunoglobulin The dose is 250IU, which does not take into account the dose difference caused by the difference in weight between children and adults; third, the human tetanus immune globulin is injected intramuscularly in the buttocks, which makes the drug difficult to spread due to the way of administration in the buttocks, and there are many tetanus bacteria The situation is that the local infection symptoms of the wound do not spread, resulting in poor pertinence of human tetanus immunoglobulin, and the effect is not direct and rapid; the fourth is that when the patient is bitten or scratched by a rabid dog or other crazy animals, he needs to Consider the risk of rabies infection, but also the risk of Clostridium tetani infection

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