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Pharmaceutical composition for treating hyperuricemia and application of pharmaceutical composition for treating hyperuricemia

A hyperuricemia and composition technology, applied in the field of medicine, can solve problems such as poor treatment effect and large side effects, and achieve the effects of improving drug safety, reducing blood uric acid value, and reducing drug risk

Inactive Publication Date: 2016-08-10
QINGDAO YUNTIAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to overcome the technical deficiencies of the existing drugs for treating hyperuricemia with relatively large side effects and poor therapeutic effect, the present invention provides a pharmaceutical composition for treating hyperuricemia, which is composed of febuxostat and iproquinone

Method used

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  • Pharmaceutical composition for treating hyperuricemia and application of pharmaceutical composition for treating hyperuricemia
  • Pharmaceutical composition for treating hyperuricemia and application of pharmaceutical composition for treating hyperuricemia
  • Pharmaceutical composition for treating hyperuricemia and application of pharmaceutical composition for treating hyperuricemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 compound tablet

[0020]

[0021] Preparation process: mix ipronacene and febuxostat with auxiliary materials microcrystalline cellulose and starch evenly, add appropriate amount of 15% starch slurry to make soft material, and then granulate through a 16-mesh sieve. Dry the wet granules at 60°C, pass the dry granules through a 16-mesh sieve for granulation, sieve out the fine powder in the dry granules, mix with magnesium stearate, and then mix with the dry granules, and press into tablets to obtain the product.

Embodiment 2

[0022] The preparation of embodiment 2 compound tablet

[0023]

[0024] Preparation process: except that the components are different, the preparation process is the same as that described in Example 1.

Embodiment 3

[0025] The preparation of embodiment 3 compound dispersible tablets

[0026]

[0027] Preparation process: Weigh iproquinone and febuxostat according to the prescription quantity, use microcrystalline cellulose as filler, croscarmellose sodium and polyvinylpyrrolidone as disintegrants, 5% PVP 60% The ethanol solution is used as the binder, the micropowdered silica gel is used as the flow aid, and it is granulated by a fluidized bed in one step, and then compressed into tablets.

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Abstract

The invention belongs to the technical field of medicines and relates to a pharmaceutical composition for treating hyperuricemia and application of the pharmaceutical composition for treating hyperuricemia. The pharmaceutical composition for treating hyperuricemia is provided to overcome technical defects of strong side effects and poor treatment effects of existing medicines for treating hyperuricemia and is composed of febuxostat and isopropylidene sedoheptuiosan. The two medicinal active components have a remarkable synergistic effect in reduction of blood uric acid and inhibition of joint swelling of rat models. Therefore, the pharmaceutical composition has an excellent treatment effect on hyperuricemia.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating hyperuricemia and an application thereof, belonging to the technical field of medicine. Background technique [0002] Hyperuricemia refers to the supersaturated state of urate in the extracellular fluid. Hyperuricemia should be considered when the blood urate of men is ≥416umol / L and that of women is ≥357umol / L. Hyperuricemia is divided into two categories: primary and secondary. Primary hyperuricemia is caused by increased uric acid production, decreased excretion, or both. Gout is a clinical syndrome caused by urate crystal deposition. It is characterized by hyperuricemia, manifested as recurrent arthritis, tophi formation, and joint deformities. Involvement of the kidneys can cause chronic interstitial nephritis and uric acid. Nephrolithiasis, severe cases may cause joint disability and renal insufficiency. Therefore, uric acid-lowering treatment is very necessary. Gout is caused ...

Claims

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Application Information

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IPC IPC(8): A61K31/426A61K31/7048A61P19/06
CPCA61K31/426A61K31/7048A61K2300/00
Inventor 王传秀
Owner QINGDAO YUNTIAN BIOTECH
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