circRNA marker for depression diagnosis, kit and gene chip

A diagnostic kit and technology for depression, applied in DNA/RNA fragments, recombinant DNA technology, organic compound library, etc., can solve problems such as increased diagnostic misdiagnosis rate, lack of specific biomarkers, and lack of objective indicators in clinical diagnosis , to improve the diagnostic accuracy and simplify the diagnostic process

Active Publication Date: 2016-08-17
张理义
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Problems solved by technology

[0006] More evidence shows that cirRNA plays a very important role in the fine-tuning of miRNA level, and regulates gene expression by competing with miRNA. Existing studies have confirmed that miRNA plays an important regulatory role in the pathogenesis of depression Therefore, cirRNA may be further involved in the pathological regulation of depression;

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  • circRNA marker for depression diagnosis, kit and gene chip
  • circRNA marker for depression diagnosis, kit and gene chip
  • circRNA marker for depression diagnosis, kit and gene chip

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[0039] The case group (MDD) was from April 2014 to January 2015, and a total of 100 patients were enrolled in the 102 Hospital of the People's Liberation Army and Changzhou Maternity and Child Health Hospital. The enrolled patients all met the MDD diagnostic criteria in the Fourth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR). Diagnosis is performed by two psychiatrists according to the Chinese version of the modified Structured Clinical Interview for DSM-IV, patientversion (SCID-I / P) (First et al., 1995) diagnostic criteria on the patients. The reliability among psychiatrists was 0.87, and finally 24 items in the HAMD scale were used to assess the severity of anxiety in patients. Enrollment criteria: 1. No antidepressants were used within three months before enrollment; 2. Han nationality, aged 18 to 60 years; 3. No history of serious organic diseases (such as heart disease, diabetes, Parkinson’s syndrome) ), no serious life trauma events oc...

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Abstract

The invention belongs to the field of biotechnology, relates to a circRNA marker for depression diagnosis and treatment effect evaluation and a kit and provides a circRNA marker for depression diagnosis. The circRNA marker comprises hsa_circRNA_002143, hsa_circRNA_103636, hsa_circRNA_100679 and hsa_circRNA_104953. The primer sequences of the four kinds of circRNA are shown in SEQ ID NO.1-8. Probes of the four kinds of circRNA are provided. The sequences of the probes are shown in SEQ ID NO.9-12. The invention further provides a circRNA marker for treatment effect evaluation of anti-depression medicine. The circRNA marker has the advantages that the depression biological marker and the circRNA biological marker for evaluating the treatment effect of antipsychotics are provided for the first time, it is clinically proved that the marker has high specificity and sensitive value and has the high diagnosis reference value, and the circRNA will bring revolutionary change of depression diagnosis and treatment by being used as the depression specificity biological marker.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to a circRNA marker, a kit and a gene chip for the diagnosis of depression. Background technique [0002] The core symptoms of depression are low mood, loss of interest, and lack of energy. More than 350 million people worldwide suffer from depression. The World Health Organization predicts that by 2020, depression will occupy the second place in the world's disease burden. Major depressive disorder is a common mental illness with a lifetime prevalence of about 2% to 14%. Major depressive disorder suicides account for 1 / 3-1 / 2 of all suicides, and their chances of comorbid cardiovascular disease and myocardial infarction are significantly higher than normal people, seriously threatening human mental and physical health. It not only seriously affects the quality of life of patients, but also has a significant impact on their social and occupational functions, burdens society with a heavy ...

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Application Information

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IPC IPC(8): C12Q1/68C12N15/11C40B40/06
CPCC12Q1/6883C12Q2600/118C12Q2600/158
Inventor 张理义
Owner 张理义
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