circRNA marker for depression diagnosis, kit and gene chip

Abstract

The invention belongs to the field of biotechnology, relates to a circRNA marker for depression diagnosis and treatment effect evaluation and a kit and provides a circRNA marker for depression diagnosis. The circRNA marker comprises hsa_circRNA_002143, hsa_circRNA_103636, hsa_circRNA_100679 and hsa_circRNA_104953. The primer sequences of the four kinds of circRNA are shown in SEQ ID NO.1-8. Probes of the four kinds of circRNA are provided. The sequences of the probes are shown in SEQ ID NO.9-12. The invention further provides a circRNA marker for treatment effect evaluation of anti-depression medicine. The circRNA marker has the advantages that the depression biological marker and the circRNA biological marker for evaluating the treatment effect of antipsychotics are provided for the first time, it is clinically proved that the marker has high specificity and sensitive value and has the high diagnosis reference value, and the circRNA will bring revolutionary change of depression diagnosis and treatment by being used as the depression specificity biological marker.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to a circRNA marker, a kit and a gene chip for the diagnosis of depression. Background technique [0002] The core symptoms of depression are low mood, loss of interest, and lack of energy. More than 350 million people worldwide suffer from depression. The World Health Organization predicts that by 2020, depression will occupy the second place in the world's disease burden. Major depressive disorder is a common mental illness with a lifetime prevalence of about 2% to 14%. Major depressive disorder suicides account for 1 / 3-1 / 2 of all suicides, and their chances of comorbid cardiovascular disease and myocardial infarction are significantly higher than normal people, seriously threatening human mental and physical health. It not only seriously affects the quality of life of patients, but also has a significant impact on their social and occupational functions, burdens society with a heavy ...

AI Technical Summary

Problems solved by technology

[0006] More evidence shows that cirRNA plays a very important role in the fine-tuning of miRNA level, and regulates gene expression by competing with miRNA. Existing studies have confirmed that miRNA plays an important regulatory role in the pathogenesis of depression Therefore, cirRNA may be further involved in the pathological regulation of depression; and the lack of specific biomarkers results in the lack of objective indicators for clinical diagnosis and increases the rate of misdiagnosis. Therefore, it is necessary to explore specific biomarkers for the diagnosis and efficacy observation of depression cirRNA is of great significance and value for the diagnosis, treatment and prevention of depression

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