Preparation method of enramycin premixing agent

A technology of enramycin and premix, which is applied in the field of preparation of enramycin premix, which can solve problems affecting quality, sales and use, low yield of enramycin, product instability, etc.

Active Publication Date: 2016-10-12
SHIJIAZHUANG GAOKE ANIMAL HEALTH PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Although enramycin has a good development prospect at home and abroad, because enramycin is added a large amount of medium during the fermentation process, the medium contains a large amount of solids, resulting in low enramycin yield and low content Low, the instability of the product, the content will be degraded after a period of time, affecting the stability of enramycin during storage and transportation, thereby affecting its quality, sales and use

Method used

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  • Preparation method of enramycin premixing agent
  • Preparation method of enramycin premixing agent
  • Preparation method of enramycin premixing agent

Examples

Experimental program
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Effect test

Embodiment 1

[0016] Control group: traditional process: the test procedure is (1) carry out plate and frame filtration with enramycin fermented liquid, the pressure of plate and frame filtration is 0.4MPa, the pressure filtration time is 3h, and air blowing time is 1.0h; (2) obtained The mycelium of enramycin is obtained after the filter cake is flash-dried, the inlet air temperature is 90-150°C, and the material temperature is 60-90°C.

[0017] Experimental group: using the present invention: a preparation method of enramycin premix, which is characterized in that it comprises the following steps: (1) carrying out plate and frame filtration of enramycin fermented liquid; (2) flash drying of the gained filter cake Finally, obtain the mycelia of enramycin: (3) fully stir after the mycelium and auxiliary material are diluted in proportion: (4) dry after the enramycin dilution is stirred evenly, obtain enramycin pre- mixture;

[0018] The weight ratio of described step (3) enramycin mycelium...

Embodiment 2

[0022] Control group: traditional process: the test procedure is (1) carry out plate and frame filtration with enramycin fermented liquid, the pressure of plate and frame filtration is 0.6MPa, the pressure filtration time is 1h, and the blowing time is 0.5h; (2) the obtained The mycelium of enramycin is obtained after the filter cake is flash-dried, the inlet air temperature is 90-150°C, and the material temperature is 60-90°C. Experimental group: using the present invention: a preparation method of enramycin premix, which is characterized in that it comprises the following steps: (1) carrying out plate and frame filtration of enramycin fermented liquid; (2) flash drying of the gained filter cake Finally, obtain the mycelia of enramycin: (3) fully stir after the mycelium and auxiliary material are diluted in proportion: (4) dry after the enramycin dilution is stirred evenly, obtain enramycin pre- mixture;

[0023] The weight ratio of described step (3) enramycin mycelium and ...

Embodiment 3

[0027] Control group: traditional process: the test procedure is (1) carry out plate and frame filtration with enramycin fermented liquid, the pressure of plate and frame filtration is 0.5MPa, the pressure filtration time is 1.5h, and blowing time is 1h; (2) obtained The mycelium of enramycin is obtained after the filter cake is flash-dried, the inlet air temperature is 90-150°C, and the material temperature is 60-90°C.

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Abstract

The invention relates to the field of processing of feed drugs, in particular to a preparation method of an enramycin premixing agent. The preparation method comprises the following steps of filtering an enramycinfermenting liquid by a plate frame; performing flash evaporation and drying on an obtained filter cake, so as to obtain enramycin mycelium; diluting the mycelium and auxiliary material according to ratio, and sufficiently stirring; uniformly stirring the mycelium diluted liquid, and drying, so as to obtain the enramycin premixing agent, wherein the weight ratio of enramycin mycelium and auxiliary material is 4 to 6, and the added auxiliary material is glycerides. The enramycin premixing agent prepared by the preparation method has the advantages that the degrading degree of the particle finished product is obviously decreased, and the stability is obviously improved.

Description

technical field [0001] The invention relates to the field of feed medicine processing, in particular to a preparation method of enramycin premix. Background technique [0002] Enramycin, also known as anlemycin, enlamycin, enleimycin, and duramycin, is obtained from the fermentation of actinomycetes. It is a polypeptide antibiotic combined with unsaturated fatty acids and more than a dozen amino acids. Originally developed in 1966 by Takeda Pharmaceutical Co., Ltd. of Japan. Enramycin has a strong inhibitory effect on Gram-positive bacteria, long-term use is not easy to produce drug resistance, and can change the distribution of bacterial communities in the intestinal tract, which is conducive to the digestion and absorption of feed nutrients, and promotes animal weight gain and improvement. Feed utilization rate, and no residue in livestock and poultry. The application effect in livestock and poultry production is remarkable. Therefore, it is used as an antibiotic growth...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/10A61K9/14A61K47/14A61P31/04
CPCA61K38/10A61K9/145Y02P60/87
Inventor 程青芳巴东风高晓华李海亭
Owner SHIJIAZHUANG GAOKE ANIMAL HEALTH PROD CO LTD
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