2H-chromene derivative containing perfluoroalkyl group, and synthetic method thereof

A technology of perfluoroalkyl and derivatives, applied in organic chemistry and other fields, can solve the problems of complicated operation, cumbersome reaction steps, and difficulty in obtaining raw materials, and achieve the effects of environmental friendliness, high atom economy, and easy operation
CN106008433AInactive Publication Date: 2016-10-12SHANGHAI UNIV
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI UNIV
Publication Date
2016-10-12
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates to a kind of containing perfluoroalkyl 2 H Chromene derivatives and synthetic methods thereof, the structure of the compound is: Wherein, R is H, methoxy, bromo, methyl or nitro; RF is trifluoromethyl or pentafluoroethyl. The method of the present invention is synthesized by two-component one-pot method, compared with the method of original report, this method uses L -Proline as a green and mild organic catalyst to synthesize perfluoroalkyl-containing 2 H -Chromene derivatives have the advantages of high atom economy, environmental friendliness, easy operation and mild conditions. The reaction uses anhydrous methanol as a solvent, which has little environmental pollution. High regioselectivity and good yield. Therefore, this method is the synthesis of perfluoroalkyl-containing 2 H - Efficient new approach to chromene derivatives.
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Description

technical field

[0001] The present invention relates to a kind of containing perfluoroalkyl 2 H -Chromene derivatives and methods for their synthesis. Background technique

[0002] Multifunctional substituted chromene (benzopyran) derivatives are a very important class of compounds due to their wide range of biological and pharmacological activities, such as antispasmodics, diuretics, anticoagulants, antitumor and antiallergic etc., so that it has been widely valued by people. Among them, 2 H -Chromene derivatives are the basic framework of a series of natural products and drugs with potential biological and pharmacological activities, so design simple and effective methods to synthesize2 H -Chromene derivatives have certain scientific significance.

[0003] However, how to synthesize rings economically and efficiently is still a hotspot in synthesis. Judging from many published research results, although there are many different multifunctional groups with novel str...

Claims

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