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Application of general anesthesia element to preparation of antithrombotic drugs

An antithrombotic drug and cannabinoid technology, which can be used in drug combinations, blood diseases, pharmaceutical formulations, etc., can solve problems such as unsatisfactory treatment effects of cannabidiol, and achieve platelet aggregation inhibition, inhibition of thrombus formation, and reduction of whole blood viscosity. Effect

Inactive Publication Date: 2016-11-09
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are also reports on antithrombotic diseases, but the therapeutic effect of cannabidiol (CBD) alone is not satisfactory

Method used

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  • Application of general anesthesia element to preparation of antithrombotic drugs
  • Application of general anesthesia element to preparation of antithrombotic drugs
  • Application of general anesthesia element to preparation of antithrombotic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The flowers, leaves, hemp bran and hemp seeds of "Yunma No. 1", an industrial hemp variety grown in Yunnan, are used as raw materials. Take mature industrial hemp hemp seeds, dry, remove impurities, and crush them for later use; use ethanol to extract the crushed hemp seeds (at 60-85°C, heat and extract twice, each time for 1-3 hours ), the ethanol concentration is 95% to 100% (V / V), and the ratio of solid to liquid is 1:5 to 1:20; the extract is filtered out and concentrated under reduced pressure to obtain the industrial hemp hemp seed extract.

[0030] Take the mixture of industrial hemp flowers, leaves and hemp bran in a mass ratio of 1:3:2, dry, remove impurities, and pulverize to 10-60 mesh; supercritical carbon dioxide extraction: put the above-mentioned pulverized industrial hemp raw materials into supercritical In the carbon dioxide extraction device, the extraction temperature is controlled at 40-50°C, the extraction time is 30-90min, the extraction pressure i...

Embodiment 2

[0033] Repeat Example 1, with the following differences: when extracting industrial hemp hemp seeds with ethanol, extract at room temperature, and extract 2 times for each batch of materials, each for 7 to 10 days. A 1:1:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as a raw material for extracting hemp cannabinoids.

[0034]Take 0.3 part of industrial hemp hemp seed extract and 99.7 parts of industrial hemp cannabinoid, and mix well to obtain the required pancannabinoid A.

Embodiment 3

[0036] Repeat Example 1, the following difference is arranged: when extracting industrial hemp hemp seed with ethanol, adopt ultrasonic assisted extraction, ultrasonic frequency 30~60kHz, power 100~1000W, extraction time 30~60min, leaching temperature 25~ 50°C. A 3:2:1 mass ratio mixture of flowers, leaves, and hemp bran of industrial hemp is used as the raw material for extracting hemp cannabinoids.

[0037] Take 99.7 parts of industrial hemp hemp seed extract and 0.3 part of industrial hemp cannabinoid, and mix well to obtain the required pancannabinoid C.

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PUM

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Abstract

The invention discloses application of a general anesthesia element to preparation of antithrombotic drugs. The general anesthesia element is formed by evenly mixing, by weight, 0.3-99.7 parts of industrial hemp fructus cannabis extract and 0.3-99.7 parts of industrial hemp cannabis elements. The drug composition general anesthesia element has an obvious antithrombotic effect. Experiments show that the general anesthesia element can obviously restrain formation of thrombus in rat bodies, has an obvious restraining effect on rat platelet aggregation, and can obviously prolong the mouse blood clotting time, reduce the whole blood viscosity, the plasma viscosity and hematokrit of rats, and the effects of the general anesthesia element are superior to those of hemp diphenol. The general anesthesia element has good application prospects.

Description

technical field [0001] The invention belongs to the technical field of industrial hemp utilization, and in particular relates to the application of a pharmaceutical composition prepared from industrial hemp as a main raw material in the preparation of antithrombotic drugs. Background technique [0002] The cultivation of hemp has a long history. In ancient times, hemp was mainly used to make and process ropes, fishing nets, clothing and paper-making raw materials, as well as oil and food. With the development and progress of society, people found that a toxic ingredient (tetrahydrocannabinol) in marijuana can make people addicted to hallucinations. Many countries in Europe and the United States have banned the cultivation of marijuana for a long time. Due to the high economic value of cannabis, by the 1980s, some European countries had researched and bred low-toxic cannabis varieties and promoted their cultivation. In 1990, the European Community took the lead in urgently r...

Claims

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Application Information

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IPC IPC(8): A61K36/60A61P7/02
CPCA61K36/60A61K2236/333A61K2236/37
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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