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A kind of medical hemostatic sponge and preparation method thereof

A hemostatic sponge and sponge technology are applied in the field of medical hemostatic sponge and its preparation, which can solve the problems of poor crystal form of chitosan sponge, cumbersome post-processing steps, long sponge degradation cycle, etc. Handling the effect of simple, fast and convenient promotion

Active Publication Date: 2020-03-17
SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The crystal form of chitosan sponge prepared by this process is not good, and the post-processing steps are cumbersome, which is not conducive to continuous production
[0007] Comparative document 2 (CN 101927027) discloses a chitosan / carboxymethyl chitosan rapid hemostatic sponge, which is made of chitosan, carboxymethyl chitosan and glycerin, and is a hybrid sponge, but the Sponge has problems such as long degradation cycle and difficult to control appearance

Method used

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  • A kind of medical hemostatic sponge and preparation method thereof
  • A kind of medical hemostatic sponge and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Adopt the following method to prepare medical hemostatic sponge:

[0065] 1. Weigh 100g of chitosan, add 500mL of ethanol, slowly add 40g of 50% acetic acid solution dropwise, stir for two hours until the salt is completely formed, filter and wash the excess acid, and dry to obtain chitosan salt.

[0066] 2. Weigh 100g of chitosan salt, add 4.5L of water for injection, then add 0.5L of tert-butanol and stir to dissolve, filter the dissolved solution, and the filtrate will enter the next step for later use.

[0067] 3. Divide the filtrate into freeze-drying molds with a thickness of 2mm. Put the divided molds into a vacuum freeze dryer, slowly cool down to -35°C, keep for 1 hour, then slowly raise the temperature to 0°C, and keep at 0°C ℃ until the product temperature reaches above 0 ℃ for 1 hour, then warm up to room temperature and continue to dry for 2 hours and shut down to obtain chitosan sponge a.

[0068] 4. Weigh 100g carboxymethyl chitosan, add 4.5L water for i...

Embodiment 2

[0072] Operation process is identical with embodiment 1, only replaces the acetic acid in embodiment 1 with hydrochloric acid.

Embodiment 3

[0074] Operation process is identical with embodiment 1, only replaces the acetic acid in embodiment 1 with lactic acid.

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Abstract

The invention relates to medical hemostatic sponge and a preparation method thereof. The hemostatic sponge is formed by bonding freeze-dried chitosan sponge and carboxymethyl chitosan sponge, and tertiary butanol is added to freeze-dried chitosan sponge and carboxymethyl chitosan sponge in the preparation process. The hemostatic sponge prepared through the process is good in crystal type, short in in-vivo degradation cycle, capable of continuously and effectively adhering to wounds, strong in dissolution resistance, good in hemostatic effect, high in production efficiency, free of toxic and side effects and free of irritation.

Description

technical field [0001] The invention belongs to the field of medicine and chemical industry, and in particular relates to a medical hemostatic sponge and a preparation method thereof. Background technique [0002] Hemorrhage control in accidental injuries has always been a major problem faced by human beings. In battlefields, natural disasters, field accidents and other accidents, uncontrolled hemorrhage is still the main cause of death of the wounded. [0003] Today, gauze compression is still the main hemostatic means, but the effect of this hemostatic means is limited. Commercially available hemostatic products such as thrombin hemostatic material, collagen hemostatic material, and modified starch may dissolve and decrease in strength when the amount of bleeding is large. In addition, the above-mentioned materials are less viscous and cannot be effectively attached to the wound surface to form a continuous sealing surface, which is likely to cause secondary bleeding, etc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L24/08A61L24/00
CPCA61L24/00A61L24/0036A61L24/0042A61L24/08C08L5/08
Inventor 梁立波张彪李素哲
Owner SHIJIAZHUANG YISHENGTANG MEDICAL SUPPLIES
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