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Guided tissue regeneration composite membrane material and preparation method thereof

A technology of tissue regeneration and composite membrane, applied in medical science, surgery, etc., to achieve the effect of promoting periodontal ligament cell adhesion, promoting periosteum cell adhesion, and good biocompatibility

Active Publication Date: 2016-11-16
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Due to the defects of a single material and preparation technology, it is difficult to meet the requirements of the ideal GTR. Therefore, using appropriate preparation technology, several materials are combined to learn from each other to prepare different tissue regeneration needs, structural steps, and functional guided tissue regeneration. membrane imperative

Method used

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  • Guided tissue regeneration composite membrane material and preparation method thereof
  • Guided tissue regeneration composite membrane material and preparation method thereof

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Embodiment 1

[0034] In this embodiment, the present invention provides a method for preparing a double-layer guided tissue regeneration composite membrane material, comprising the following steps:

[0035] A loose layer of high molecular polymer and phosphate inorganic matter is prepared at the bottom. The steps for preparing the loose layer of high molecular polymer / phosphate inorganic matter are described in detail below:

[0036] Step 1, using template induction and self-assembly methods to synthesize phosphate inorganic substances. The non-ionic block copolymer is used as a structure-directing agent and dissolved in deionized water, stirred with a magnetic force until the solution is clarified; the pH value of the solution system is adjusted to pH=1 with 37% concentrated hydrochloric acid, and stirred for 2 hours until the solution becomes a white emulsion. Then add tetraethyl orthosilicate, calcium nitrate and triethyl phosphate into the solution reaction system, then put it into a s...

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Abstract

The invention provides a guided tissue regeneration composite membrane material. The guided tissue regeneration composite membrane material is characterized by being in a double-layer membrane structure, wherein the double-layer membrane structure comprises a loose layer on the bottom layer and a compact layer on the upper layer. According to a second aspect, the invention provides a preparation method of the guided tissue regeneration composite membrane material. According to the guided tissue regeneration composite membrane material and the preparation method, the biological membrane material having the customized specification, having the tissue integration activity, and being capable of promoting the growth of the osteoblasts can be printed by adopting a three-dimensional printer, a material with the capacity of promoting the periodontal ligament cell adhesion and the periosteum cell adhesion is prepared by combining with the electrospinning technology, and a medicine having the antimicrobial activity is combined, therefore, the guided tissue regeneration composite membrane material has good biocompatibility, good bone repair function and good bacteria resisting function, and can be used for the periodontal guided tissue regeneration treatment and periosteum defect repair.

Description

technical field [0001] The invention relates to the field of medical biomaterials, in particular to a guided tissue regeneration composite membrane material and a preparation method thereof. Background technique [0002] In the late 1970s and early 1980s, Nyman, Lindhe, Karring, Gottlow and other scholars proposed a series of guided tissue regeneration (Guided Tissue Regeneration, hereinafter referred to as GTR) for the treatment of periodontal disease, the core of which is to use tissue to guide the regeneration membrane, namely Through the role of space barrier, the gingival epithelium and connective tissue are prevented from attaching to the root surface quickly during the healing process, so that the periodontal ligament cells with regenerative ability preferentially occupy the root surface and form new attachments, so as to achieve periodontal support tissue regeneration . Therefore, the guiding membrane is one of the crucial factors for GTR therapy. With the developm...

Claims

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Application Information

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IPC IPC(8): A61L31/12A61L31/16A61L31/14
CPCA61L31/026A61L31/042A61L31/044A61L31/048A61L31/06A61L31/148A61L31/16A61L2300/404A61L2300/412A61L2300/414
Inventor 汤亭亭陆尔奕杨盛兵茅传圆
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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