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Lagotis brevituba extract, preparation methods and application thereof, and externally-applied extract-containing agent for skins

A technology of short-tube rabbit ear grass and skin external preparation, which can be applied in the directions of skin care preparations, skin diseases, drug combinations, etc., can solve the problems of poor anti-aging and whitening effect, low safety, etc. Effect

Inactive Publication Date: 2017-01-04
JALA GROUP CORPORATION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The technical problem to be solved by the present invention is to provide a short-tube rabbit ear grass extract, its preparation method and application, and an external skin preparation containing it in order to overcome the defects of cosmetics in the prior art such as poor anti-aging and whitening effects and low safety.

Method used

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  • Lagotis brevituba extract, preparation methods and application thereof, and externally-applied extract-containing agent for skins
  • Lagotis brevituba extract, preparation methods and application thereof, and externally-applied extract-containing agent for skins
  • Lagotis brevituba extract, preparation methods and application thereof, and externally-applied extract-containing agent for skins

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Embodiment 1 is that the ethanol aqueous solution of 50% is extraction solvent (method 1) with volume concentration

[0037] 20g of dry powder of the short-tube rabbit's ear grass (the particle size of the short-tube rabbit's ear grass powder is 20 meshes), at room temperature (25°C) with 200ml of ethanol aqueous solution with a volume concentration of 50%, ultrasonic extraction 2 times, each time for 30min (power 500W), take the filtrate and combine, depressurize (50 ℃) to recover the solvent to dryness, take an appropriate amount of extract, add DMSO (dimethyl sulfoxide) to prepare a 0.05mg / ml solution for later use, measure its free radical scavenging effect, its free Base clearance was 15%.

Embodiment 2

[0038] Embodiment 2 is that the ethanol aqueous solution of 60% is extraction solvent (method 1) with volume concentration

[0039] 20g of dry powder of the short-tube rabbit's ear grass (the particle size of the short-tube rabbit's ear grass powder is 30 mesh), at room temperature (25°C) with 200ml of ethanol aqueous solution with a volume concentration of 60%, ultrasonic extraction twice, each time for 30min (power 500W ), take the filtrates and combine them, recover the solvent under reduced pressure (50°C) to dryness, take an appropriate amount of extract, add DMSO (dimethyl sulfoxide) to prepare a 0.05mg / ml solution for later use, measure its free radical scavenging effect, and its free radical scavenging The rate is 17%.

Embodiment 3

[0040] Embodiment 3 is that the ethanol aqueous solution of 70% is extraction solvent (method 1) with volume concentration

[0041] 20g of dry powder of the short-tube rabbit's ear grass (the particle size of the short-tube rabbit's ear grass powder is 40 mesh), at room temperature (25°C) with 200ml of ethanol aqueous solution with a volume concentration of 70%, ultrasonic extraction twice, each time for 30min (power 500W ), take the filtrates and combine them, recover the solvent under reduced pressure (50°C) to dryness, take an appropriate amount of extract, add DMSO (dimethyl sulfoxide) to prepare a 0.05mg / ml solution for later use, measure its free radical scavenging effect, and its free radical scavenging The rate is 48%.

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PUM

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Abstract

The invention discloses a Lagotis brevituba extract, preparation methods and an application thereof, and an externally-applied extract-containing agent for skins. The preparation method 1 of the Lagotis brevituba extract comprises the following steps: 1, extracting a mixture formed by Lagotis brevituba powder and an ethanol-water solution with the volume concentration of 50-80% at 10-35 DEG C for 0.5-5 h, carrying out solid-liquid separation to obtain a filtrate, and removing a solvent from the filtrate, wherein a mass / volume ratio of the Lagotis brevituba powder to the ethanol-water solution of 1:8-1:15 mg / mL. The preparation method 2 of the Lagotis brevituba extract comprises the following steps: adding crude Lagotis brevituba extract obtained in the method 1 to a macro-porous resin packed column, sequentially eluting with a solvent I, a solvent II and a solvent III, and respectively collecting obtained eluates, and removing the solvents to obtain a solvent elution part A, a solvent elution part B and a solvent elution part C. The Lagotis brevituba extract has good whitening, ageing preventing and oxidation preventing effects, and has good market prospect.

Description

technical field [0001] The present invention relates to the preparation method and application of the rabbit's ear grass extract, and the skin external preparation containing it. Background technique [0002] In 1956, Harman proposed the theory of free radical aging [Harman, D. Aging: A theory based on free radical and radiation chemistry. J. Gerontol. 1956, 11: 289-300.], thinking that excessive free radicals are the cause of biological aging important reason. According to this theory, excess active oxygen free radicals in the body react with unsaturated fatty acids to produce substances such as malondialdehyde, and malondialdehyde will react with proteins on the cell membrane to produce brown pigment, which precipitates on the skin and becomes various stains. Excessive free radicals can also cause cross-linking and denaturation of collagen fibers and elastic fibers in the skin, making them brittle and losing elasticity. When the skin is insufficiently hydrated, it is easy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/898A61K8/97A61Q19/02A61Q19/08A61P17/18A61P17/00
Inventor 金家宏
Owner JALA GROUP CORPORATION
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