Anti-cancer transdermic absorption preparation

An anti-cancer and preparation technology, applied in the field of percutaneous absorption preparations, to achieve the effects of easy acceptance, high controllability and good absorption

Inactive Publication Date: 2017-02-08
罗观堤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In vitro cytotoxicity experiments and differences in anticancer efficacy of patients indicate that disulfiram passes through the gastrointestinal system, liver first-

Method used

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  • Anti-cancer transdermic absorption preparation
  • Anti-cancer transdermic absorption preparation
  • Anti-cancer transdermic absorption preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] (1) Formulation 1-3

[0053] Table 1 Formulations 1-3

[0054]

[0055] Remarks: For this recipe and the following recipes, every 1 serving is equivalent to 1%, every 10 servings is equivalent to 10%, and so on.

[0056] (2) Method

[0057] Preparation of oil phase: Take the thickener, emulsifier (part) and matrix in the prescribed amount and add them to the beaker in turn, shake well, heat in a water bath to 80°C, and keep warm. Separately take the formula amount of transdermal accelerator and preservative, put it in the Erlenmeyer flask, shake it with the formula amount of absolute ethanol, dissolve it, add the formula amount of the main drug, heat and shake it in a water bath at 80°C, then add it to the above-mentioned 1 beaker In the process, use a constant speed high-speed dispersing homogenizer, 7kr / min, and homogenize for 2 minutes.

[0058] Water phase preparation: Put the formulated amount of emulsifier (the remaining part), humectant, inclusion agent and...

Embodiment 2

[0061] (1) Formulation 4-6

[0062] Table 2 Formulations 4-6

[0063]

[0064] (2) Method

[0065] The preparation method is the same as that of formula 1-3.

Embodiment 3

[0067] (1) Recipe 7-9

[0068] Table 3 Formulations 7-9

[0069]

[0070] (2) Method

[0071] The preparation method is the same as that of formula 1-3.

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Abstract

The invention relates to an anti-cancer transdermic absorption preparation. The preparation formula is prepared from the following forming components in parts by weight: 0.1 to 10 parts of a primary medicine, 0.1 to 23 parts of a substrate, 0.1 to 15 parts of a humectants, 0.5 to 15 parts of a thickening agent, 0.1 to 10 parts of an emulsifier, 0.1 to 10 parts of a transdermal enhancer, 1 to 10 parts of an inclusion agent, 0 to 2 parts of a preservative, and 45 to 85 parts of a wetting agent, wherein the primary medicine is one or a mixture of two or more components of DDC (diethyldithiocarbamic acid)-Zn, DDC-Cu and DS (disulfiram). The anti-cancer transdermic absorption preparation has the advantages of stable physical property and chemical property, high absorption performance, high medicine controllability, easiness in use and favorability for acceptance by patients, and can be widely applied to anti-cancer treatment of in-patients and out-patients suffering from malignant tumors.

Description

technical field [0001] The invention relates to an anti-cancer percutaneous absorption preparation. Background technique [0002] Malignant tumors are the primary threat to human health. The incidence of malignant tumors in my country is in a period of rapid increase, with an annual incidence of malignant tumors of about 2.6 million and 1.8 million deaths. Malignant tumors have become the number one cause of death among urban and rural residents in China. At present, most malignant tumors are still regarded as "incurable diseases". Treatment methods for malignant tumors include surgery, radiation therapy, and chemotherapy. Traditional chemotherapy drugs have poor selectivity, strong drug resistance and serious adverse reactions. Therefore, it is imminent to develop tumor therapeutic drug preparations with good curative effect and high safety. The purpose of the present invention is to research and develop novel high-efficiency and safe anti-malignant tumor new drugs. ...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K33/34A61K33/30A61K31/145A61P35/00
CPCA61K33/34A61K9/0014A61K31/145A61K33/30A61K47/06A61K47/10A61K2300/00
Inventor 王伟光罗观堤李娜王志鹏张仁贵
Owner 罗观堤
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