A device for forming multi-substance gradient mixed droplet based on microfluidic chip

Abstract

The invention provides a multi-material gradient mixed liquid drop formation device based on a micro-fluidic chip. The device comprises an upper layer micro-fluidic chip, a middle layer micro-fluidic chip and a lower layer plate chip. Solution entrances, microchannel networks and solution exits are arranged on the upper layer micro-fluidic chip and the middle layer micro-fluidic chip respectively; the microchannel networks of the upper layer micro-fluidic chip and the middle layer micro-fluidic chip are composed of concentric annular channels and radial subchannels with same quantity which are connected in an alternatively distributed mode respectively; the solution entrances of the upper layer micro-fluidic chip and the middle layer micro-fluidic chip are communicated with the first concentric annular channel and the first set of radial subchannels in same-layer chip microchannel networks respectively; the solution exits of the upper layer micro-fluidic chip and the middle layer micro-fluidic chip are communicated with the last set of radial subchannels in the same-layer chip microchannel networks respectively, and the solution exits of the upper layer micro-fluidic chip is communicated with the solution exits of the middle layer micro-fluidic chip and corresponds to the solution exits of the middle layer micro-fluidic chip one to one.

Description

technical field [0001] The invention belongs to the technical field of chemical analysis, and in particular relates to a multi-substance gradient mixed droplet forming device based on a microfluidic chip. Background technique [0002] In drug sustained-release research, the preparation of sustained-release drug-loaded particles is the first work to be done. Because it is necessary to investigate the combined therapeutic effect of different drugs and the dosage ratio of different drugs, the synthesis and preparation of particles with different contents and contents with different ratios are often involved in the particle synthesis process. In the field of analytical chemistry, analysis and detection based on suspension microcarriers is a widely used detection technology. The suspension carriers used are generally spherical particles with luminescent properties. In the detection, the identification of the particles is realized by identifying the difference in the optical sign...

AI Technical Summary

Problems solved by technology

However, this device has the following disadvantages: firstly, it can only produce mixed droplets of two substances, and its application range is still limited; secondly, it still uses the traditional microfluidic droplet formation technology, which requires both aqueous phase and The two solutions of the oil phase are introduced into the chip at the same time and driven, so the complexity and instrument cost are relatively high; in addition, the channel design of this type of chip is relatively complicated, including both the water phase channel and the oil phase channel, and the two phases are in the channel. The flow in the network is in the opposite direction, and turbulent flow and reverse flow are likely to occur if the fluid drive is slightly careless. Therefore, there are high requirements for the operator's operating ability and control level, as well as the processing accuracy of the chip, and it is not suitable for non-professionals to master; Furthermore, the droplet formation structure it adopts is a U-shaped structure, which causes the droplet channels to be mixed between the oil phase channels, making it difficult to observe.

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