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A kind of piglet antibacterial microcapsule

A technology of microcapsules and piglets, which is applied in the direction of microcapsules, antibacterial drugs, and capsule delivery, etc. It can solve the problems of low immune resistance, diarrhea disease, and low survival rate of piglets, so as to regulate the body's metabolism and prevent piglets from stress Reaction, the effect of improving growth performance

Active Publication Date: 2019-12-31
播恩集团股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] With the continuous improvement of large-scale breeding, early weaning of piglets is becoming more and more common. It can not only improve the productivity of sows and the utilization rate of housing equipment, but also reduce the maternal transmission of diseases, and can also improve the growth performance of piglets and However, due to the immature development of the gastrointestinal system after weaning, piglets often have problems such as loss of appetite, indigestion, and diarrhea, which eventually manifest as growth inhibition; and because the immune system of piglets is not fully developed after weaning, immune Low resistance, very vulnerable to pathogenic bacteria, fungi, viruses, greatly increasing the incidence rate, making the survival rate of piglets low
[0003] Bacillus amyloliquefaciens can secrete a variety of digestive enzymes and antibacterial substances during the metabolic process, which can inhibit pathogenic bacteria, fungi, viruses, etc., can improve the digestion and absorption of nutrients by animals, maintain the balance of intestinal flora of livestock and poultry, and inhibit harmful pathogenic bacteria growth and enhance the ability to resist diseases. At present, Bacillus amyloliquefaciens is widely used in plant protection as a biological control bacterium, and has a good inhibitory effect on plant diseases and insect pests. In addition, in aquaculture, the application of Bacillus amyloliquefaciens It can significantly improve the water environment and increase the survival rate of fish, but there are few studies on the application of Bacillus amyloliquefaciens to piglets for antibacterial effects; piglets are the prerequisite for the entire pig breeding industry. To meet the development needs of piglets, it is of great significance to develop a new type of preparation that can antibacterial, sterilize, and improve the survival rate of piglets. a new way of thinking

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] A microcapsule for antibacterial piglets, which consists of the following raw materials in parts by weight: 15 kg of Bacillus amyloliquefaciens, 5 kg of traditional Chinese medicine enhancer, 2 kg of kaolin, 5 kg of magnesium aluminum hydroxide, 8 kg of ethyl cellulose, 6 kg of methyl cellulose, Butylated hydroxyanisole 2kg, ultrapure water 90kg;

[0025] Piglet antibacterial microcapsules, its preparation method comprises the following steps:

[0026] (1) Bacillus amyloliquefaciens treatment: Inoculate the Bacillus amyloliquefaciens strains on the culture medium. After 24 hours, add 1 colony into a Erlenmeyer flask filled with 1L culture medium, place it on a shaker and shake it overnight, then centrifuge 15min, discard the supernatant, mix the precipitate with double distilled water, concentrate with a rotary evaporator, pass through a 0.22μm bacterial filter, let stand for 2h, centrifuge, discard the supernatant, dissolve the precipitate with ultrapure water, add Pr...

Embodiment 2

[0037] A microcapsule for piglet antibacterial, which is composed of the following raw materials in parts by weight: 20 kg of Bacillus amyloliquefaciens, 10 kg of traditional Chinese medicine enhancer, 3 kg of kaolin, 7 kg of magnesium aluminum hydroxide, 12 kg of ethyl cellulose, 9 kg of methyl cellulose, Butylated hydroxyanisole 4kg, ultrapure water 100kg;

[0038] Piglet antibacterial microcapsules, its preparation method comprises the following steps:

[0039](1) Bacillus amyloliquefaciens treatment: inoculate the Bacillus amyloliquefaciens strains on the culture medium, and after 48 hours, add 1 colony into a Erlenmeyer flask filled with 1L culture medium, place it on a shaker and shake it overnight, then centrifuge 20min, discard the supernatant, mix the precipitate with double distilled water, concentrate with a rotary evaporator, pass through a 0.22μm bacterial filter, let stand for 3h, centrifuge, discard the supernatant, dissolve the precipitate with ultrapure water,...

Embodiment 3

[0050] A microcapsule for piglet antibacterial, which is composed of the following raw materials in parts by weight: 18 kg of Bacillus amyloliquefaciens, 8 kg of traditional Chinese medicine enhancer, 2.6 kg of kaolin, 6 kg of magnesium aluminum hydroxide, 10 kg of ethyl cellulose, and 8 kg of methyl cellulose , Butylated hydroxyanisole 3kg, ultrapure water 95kg;

[0051] Piglet antibacterial microcapsules, its preparation method comprises the following steps:

[0052] (1) Bacillus amyloliquefaciens treatment: Inoculate the Bacillus amyloliquefaciens strains on the culture medium. After 26 hours, add 1 colony into a Erlenmeyer flask filled with 1L culture medium, place it on a shaker and shake it overnight, then centrifuge 18min, discard the supernatant, mix the precipitate with double distilled water, concentrate with a rotary evaporator, pass through a 0.22μm bacterial filter, let stand for 2.5h, centrifuge, discard the supernatant, dissolve the precipitate with ultrapure wa...

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PUM

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Abstract

The invention relates to the technical field of veterinary biological products, in particular to antibacterial microcapsules for piglets. The antibacterial microcapsules are composed of, by weight, 15-20 parts of bacillus amyloliquefaciens, 5-10 parts of traditional Chinese medicine enhancer, 2-3 parts of kaolin, 5-7 parts of magnesium aluminum hydroxide, 8-12 parts of ethyl cellulose, 6-9 parts of methyl cellulose, 2-4 parts of butyl hydroxy anisole and 90-100 parts of ultrapure water. The antibacterial microcapsules can stimulate the piglets to generate immunity, help the piglets to establish an intestinal microecological system as soon as possible, prevent digestive tract structures of the piglets from being damaged, prevent fungi, viruses and pathogenic microorganisms from invading the piglets and prevent stress reaction of the piglets and have effects of improving stress resistance and disease resistance of the piglets and regulating body metabolism, morbidity and mortality can be reduced effectively, diarrhea of the piglets can be remarkably reduced, and growing performance of the piglets is improved.

Description

technical field [0001] The invention relates to the technical field of veterinary biological products, in particular to a microcapsule for piglet antibacterial. Background technique [0002] With the continuous improvement of large-scale breeding, early weaning of piglets is becoming more and more common. It can not only improve the productivity of sows and the utilization rate of housing equipment, but also reduce the maternal transmission of diseases, and can also improve the growth performance of piglets and However, due to the immature development of the gastrointestinal system after weaning, piglets often have problems such as loss of appetite, indigestion, and diarrhea, which eventually manifest as growth inhibition; and because the immune system of piglets is not fully developed after weaning, immune The resistance is low, and it is extremely vulnerable to pathogenic bacteria, fungi, and viruses, which greatly increases the incidence rate and makes the survival rate o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61K9/50A61K47/38A61P31/04A61P1/12A61K35/742A61K35/57A61K35/32
CPCA61K9/5042A61K35/32A61K35/57A61K35/742A61K36/236A61K36/282A61K36/288A61K36/34A61K36/575A61K36/605A61K36/634A61K36/752A61K36/804A61K36/86A61K36/8965A61K36/8968A61K36/898A61K36/8994A61K2300/00
Inventor 张艳雯郑一民张宁兰宗宝
Owner 播恩集团股份有限公司
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