A kind of hydrogel material for 3D bioprinting and its preparation method and application

A bioprinting and 3D printing technology, applied in additive processing, prosthesis, medical science and other directions, to achieve the effect of small immune rejection, good industrialization prospects, and rapid gel formation
CN106474560BActive Publication Date: 2019-08-02JINAN UNIVERSITY
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
JINAN UNIVERSITY
Publication Date
2019-08-02

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Abstract

The invention belongs to the technical field of biological materials, and discloses a hydrogel material for 3D bioprinting and a preparation method and application of the hydrogel material. The hydrogel material comprises the following components in percentages by mass: 0.5-10% of gellan gum and / or derivatives, 0.1-20% of PEG and / or derivatives thereof, 0-1% of a crosslinking initiator, 0-15% of biologically active components and the balance of a solvent. The hydrogel material is double-network hydrogel based on the gellan gum and PEG; interpenetrating double-network structures are formed in a physiological environment; and the hydrogel material has good structure and dimensional stability, and has the advantages of quick gum formation under physiological conditions, excellent cell compatibility, small immunological rejection, high cell encapsulation efficiency, controllable mechanical strength, biodegradability and the like. The hydrogel material is applied to 3D bioprinting; the shortcomings of low curing speed, harsh curing conditions, limited mechanical properties, poor cell compatibility and the like are overcome; and the hydrogel material has obvious advantages and good industrialized prospect.
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Description

technical field

[0001] The invention belongs to the technical field of biomaterials, in particular to a hydrogel material for 3D bioprinting and its preparation method and application. Background technique

[0002] 3D bioprinting is a new type of tissue engineering technology developed on the basis of the development of rapid prototyping technology, combined with the research results of cell biology, computer-aided design and biomaterials. Its ultimate goal is to realize Organ prints. 3D bioprinting technology can overcome the limitations of traditional tissue engineering technology. By precisely positioning the position between biomaterials, biochemical molecules and living cell layers, it can realize the three-dimensional precise positioning of seed cells with different densities in different scaffold materials, and control the functional The spatial location of components, used to fabricate 3D structures.

[0003] Hydrogel has high water content, good biocompatibility, ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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